Contamination and adulteration of herbal medicinal products (HMPs): an overview of systematic reviews

Posadzki, Paul; Watson, Leala K.; Ernst, Edzard

doi:10.1007/s00228-012-1353-z

Cited by 197 publications

(119 citation statements)

References 30 publications

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“…As a result of insufficient herbal product regulations, some ADR may 21 be attributable to a lack of standardization, contamination, adulteration, plant misidentification/substitution, improper use of herbal medicines including their inappropriate labeling rather than pharmacological/toxicology effects of herbals [5][6][7]31]. Also, implementation of innovative preparation methods of traditionally used herbal remedies may alter pharmacological/toxicological properties of herbs and lead to their toxicity rather than therapeutic use.…”

Section: Suspect Herbalsmentioning

confidence: 99%

“…In most countries, herbal medicines are defined as dietary supplements and as such do not have to meet pre-and postmarketing drug policy regulations [5]. However, use of herbal medicines can be associated with development of severe adverse reactions as a result of complex chemistry of herbals as well as their inappropriate use and a lack of quality control [6,7]. In addition, patients may not disclose self-medication with herbal medicines to their health care professionals, and even if they do there may be limited knowledge of their potential adverse reactions and interactions with concomitantly used prescription drugs [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase®

et al. 2016

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INTRODUCTION Herbal medicines are used worldwide and with an increasing popularity in Western countries. Although often perceived as 'naturally safe', herbals may cause severe adverse drug reactions (ADRs), with immediate allergic reactions being particularly life threatening. OBJECTIVES The aim of this study was to analyse immediate allergy-like ADRs to herbals documented in VigiBase(®), the WHO international pharmacovigilance database. METHODS The documentation of all suspected ADRs in association with herbal exposure reported to VigiBase(®) from 1969 to August 2014 was retrieved. Among all reports in which WHO-ART reaction terms were indicative of acute allergic reactions, those classified as 'suspect' with a documented causality assessment and latency time of 1 day were selected. For the most frequent specific herbal-ADR combinations, the information component (IC) as a measure of disproportionality based on Bayesian statistics was calculated. RESULTS We identified 757 reports out of 1039 ADRs. Products with mixed herbals (36.0 %) as well as those administered orally (63.2 %) were predominant. The most frequent reactions were urticaria and rash (49.2 %). Anaphylactic reactions accounted for 9.5 %. Disproportionally frequent reporting of mouth edema (IC = 1.81) and anaphylactic reactions (IC = 1.24) to Phleum pretense were noted. CONCLUSION Our findings indicate that herbal medicines for oral use carry a risk of causing immediate allergy-like ADRs. Studies using the Vigibase(®) database can identify specific combinations of particular herbs and adverse reactions. Healthcare professionals and patients should be aware of these risks and report any serious adverse experiences. Results:We identified 757 reports with 1,039 ADR. Products with mixed herbals (36.0%) and oral administration (63.2%) were predominant. The most frequent reactions were urticaria and rash (49.2%).Anaphylactic reactions accounted for 9.5%. We found disproportionally frequent reporting of mouth oedema (IC=1.81) and anaphylactic reactions (IC=1.24) with Phleum pratense. Conclusion:Our findings indicate that herbal medicines for oral use carry a risk for allergy-like immediate ADR.Studies using the Vigibase ® database can identify specific combinations of particular herbs and adverse reactions. Health care professionals and patients should be aware of these risks and report any serious adverse experiences.

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Section: Suspect Herbalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase®

et al. 2016

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“…An interaction of herbal constituents with synthetic drugs can dan-gerously strengthen or weaken an effect of the latter ones, often interfering with the drug metabolism [6]. Another problem can be due to contamination of the raw herbal material with various different adulterants which can increase the toxicity of phytotherapeutic agents [7]. Detailed mechanisms of herbal action still remain unproven, although the health-promoting effect of the herbs seems to rely more on the synergism among different plant components than on the effects of individual compounds [8].…”

Section: Introductionmentioning

confidence: 99%

Qualitative evaluation of composition of the volatile fraction in commercial samples of Cistus incanus L.

Szeremeta

Knaś

Długosz

et al. 2017

Acta Chromatographica

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Summary. The present research is focused on identification of volatile components of different commercial products containing raw herbs of Cistus incanus L. The dried herbal material was hydrodistilled, and the obtained essential oils were analyzed by means of gas chromatography with mass spectrometric detection. Alternatively, the headspace analysis of the volatile sample components was also performed. It was found out that the investigated samples of the C. incanus L. species show a wide variation in terms of quality and quantity of the respective essential oils, which might result in their variable biological activity also. In conclusion, a postulate for standardization of chemical composition of the raw plant material used in therapeutic preparations is formulated.

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“…To cure these anomalies, natural as well synthetic drugs has been used from ages. As, bundles of side effects related to allopathic drugs have been reported [1,2] to get secure and sound treatment many people turned towards plant based medications. Literature revealed that 80% of the world population avail herbal therapeutic and their uses are rising every year [1].…”

Section: Introductionmentioning

confidence: 99%

“…Solvents, such as methanol, ethanol, acetone, propenol, benzene and ethyl acetate etc., have been commonly used for the extraction of phenolics from fresh product. And thus generate assorted activity in biological system [2,4,6,7].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Relative Anti-Diabetic Activity of Seven Extracts of Three Herbs in Alloxan Induced Diabetic Rats.

Sharma¹,

Mehta²

2016

IOSR

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Contamination and adulteration of herbal medicinal products (HMPs): an overview of systematic reviews

Cited by 197 publications

References 30 publications

Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase®

Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase®

Qualitative evaluation of composition of the volatile fraction in commercial samples of Cistus incanus L.

Assessment of Relative Anti-Diabetic Activity of Seven Extracts of Three Herbs in Alloxan Induced Diabetic Rats.

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