Containers for Drug Delivery

Ganguly, Sayan; Das, Poushali; Margel, Shlomo

doi:10.1007/978-981-16-8146-2_6

Cited by 7 publications

(6 citation statements)

References 138 publications

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“…Swelling-controlled release happens when diffusion of the medication occurs more quickly than swelling of the hydrogel [ 98 , 99 ]. The modeling of this process often requires the use of shifting boundary conditions, in which molecules are allowed to escape at the border between the rubbery and glassy phases of inflated hydrogels [ 100 ].…”

Section: Release Mechanismmentioning

confidence: 99%

Doped Carbon Quantum Dots Reinforced Hydrogels for Sustained Delivery of Molecular Cargo

Kanungo¹,

Gupta²,

Rawat³

et al. 2023

JFB

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Hydrogels have emerged as important soft materials with numerous applications in fields including biomedicine, biomimetic smart materials, and electrochemistry. Because of their outstanding photo-physical properties and prolonged colloidal stability, the serendipitous findings of carbon quantum dots (CQDs) have introduced a new topic of investigation for materials scientists. CQDs confined polymeric hydrogel nanocomposites have emerged as novel materials with integrated properties of the individual constituents, resulting in vital uses in the realm of soft nanomaterials. Immobilizing CQDs within hydrogels has been shown to be a smart tactic for preventing the aggregation-caused quenching effect and also for manipulating the characteristics of hydrogels and introducing new properties. The combination of these two very different types of materials results in not only structural diversity but also significant improvements in many property aspects, leading to novel multifunctional materials. This review covers the synthesis of doped CQDs, different fabrication techniques for nanostructured materials made of CQDs and polymers, as well as their applications in sustained drug delivery. Finally, a brief overview of the present market and future perspectives are discussed.

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Section: Release Mechanismmentioning

confidence: 99%

Doped Carbon Quantum Dots Reinforced Hydrogels for Sustained Delivery of Molecular Cargo

Kanungo¹,

Gupta²,

Rawat³

et al. 2023

JFB

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“…In recent years, there has been a growing interest in nanopharmaceuticals, which has resulted in a number of technological developments with an emphasis on the development of new applications. The active phytoconstituents or standardized extracts of plants are what are used to make nanophytomedicines ( Ganguly and Margel, 2021 ; Ganguly et al, 2022 ). It was discovered that a nanotized herbal medication that contained the active ingredients of seawort, cassia twig, and liquorice root was successful in treating cancers of the liver, lungs, bones, and skin.…”

Section: Bioinspired Qd Medication Deliverymentioning

confidence: 99%

Surface decorated quantum dots: Synthesis, properties and role in herbal therapy

Baig¹,

Suryawanshi

Zehravi

et al. 2023

Front. Cell Dev. Biol.

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Quantum dots are the serendipitous outcome of materials research. It is the tiny carbonaceous nanoparticles with diameters ranging from 1 to 10 nm. This review is a brief discussion of the synthesis, properties, and biomedical applicability of quantum dots, especially in herbal therapy. As quantum dots are highly polar, they can be surface decorated with several kinds of polar functionalities, such as polymeric molecules, small functional molecules, and so on. The review also consists of the basic physical and optical properties of quantum dots and their excitation―dependent properties in the application section. We focus on therapeutics, where quantum dots are used as drugs or imaging probes. Nanoprobes for several diagnostics are quite new in the biomedical research domain. Quantum dot―based nanoprobes are in high demand due to their excellent fluorescence, non-bleaching nature, biocompatibility, anchoring feasibility for several analytes, and fast point―of―care sensibility. Lastly, we also included a discussion on quantum dot―based drug delivery as phytomedicine.

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“…This is particularly true for poorly water-soluble drugs, which are a challenge for pharmaceutical scientists, and unfortunately a large number of newly discovered drugs are slightly water-soluble. After the oral administration of a drug in a solid form (tablets, capsules, or suspensions) and before adsorption, it is necessary for it to be released and then dissolved in the gastrointestinal fluids [ 3 , 4 ]. The dissolution rate is the limiting step of the bioavailability of a large number of poorly water-soluble drugs.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Nanorods Based Drug Delivery Systems for Bumetanide and Meloxicam, Poorly Water Soluble Active Principles

Friuli,

Maggi,

Bruni

et al. 2024

Nanomaterials

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Poorly water-soluble drugs represent a challenge for the pharmaceutical industry because it is necessary to find properly tuned and efficient systems for their release. In this framework, organic–inorganic hybrid systems could represent a promising strategy. A largely diffused inorganic host is hydroxyapatite (HAP, Ca10(PO4)6(OH)2), which is easily synthesized with different external forms and can adsorb different kinds of molecules, thereby allowing rapid drug release. Hybrid nanocomposites of HAP nanorods, obtained through hydrothermal synthesis, were prepared with two model pharmaceutical molecules characterized by low and pH-dependent solubility: meloxicam, a non-steroidal anti-inflammatory drug, and bumetanide, a diuretic drug. Both hybrids were physically and chemically characterized through the combined use of X-ray powder diffraction, scanning electron microscopy with energy-dispersive spectroscopy, differential scanning calorimetry, and infrared spectroscopy measurements. Then, their dissolution profiles and hydrophilicity (contact angles) in different media as well as their solubility were determined and compared to the pure drugs. This hybrid system seems particularly suitable as a drug carrier for bumetanide, as it shows higher drug loading and good dissolution profiles, while is less suitable for meloxicam, an acid molecule.

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Containers for Drug Delivery

Cited by 7 publications

References 138 publications

Doped Carbon Quantum Dots Reinforced Hydrogels for Sustained Delivery of Molecular Cargo

Doped Carbon Quantum Dots Reinforced Hydrogels for Sustained Delivery of Molecular Cargo

Surface decorated quantum dots: Synthesis, properties and role in herbal therapy

Hydroxyapatite Nanorods Based Drug Delivery Systems for Bumetanide and Meloxicam, Poorly Water Soluble Active Principles

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