Contagious Papular Dermatitis of Japanese Serows in Niigata Prefecture

Ogino, Hiroaki; Nakabayashi, Dai; Nabeya, Masahiro; Hoshi, Kunio; Okazawa, Takeo

doi:10.12935/jvma1951.49.615

Cited by 8 publications

(5 citation statements)

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“…Although several parapoxviruses have been isolated from sheep and cattle with or without clinical symptoms, these isolates have not been classified biologically and molecularly. Moreover, parapoxvirus infections in wild Japanese serows ( Capricornis crispus ) have been prevalent continuously in various areas since the 1970s (Inoshima et al , 1999 , 2000 b , 2001 ) and experimental transmission of parapoxvirus from the Japanese serow to cattle, sheep and goats has also succeeded (Ogino et al , 1996 ; Okada et al , 1986 ). The parapoxviruses circulating among Japanese serows have not yet been identified and the relationship between the virus in domestic animals and that in Japanese serows remains unclear.…”

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Genetic heterogeneity among parapoxviruses isolated from sheep, cattle and Japanese serows (Capricornis crispus)

Inoshima

Murakami

Yokoyama

et al. 2001

Journal of General Virology

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Standard strains of four parapoxviruses and seven unclassified Japanese strains isolated from sheep, cattle and wild Japanese serows (Capricornis crispus) were compared molecularly. Restriction fragment length polymorphism (RFLP) analysis of viral DNA, indirect immunofluorescence assays using monoclonal antibodies, partial nucleotide sequencing of the envelope gene, phylogenetic analysis and PCR-RFLP were carried out. These analyses revealed that the parapoxviruses were divided into four groups and the region sequenced in this study was highly conserved within each group. Each of the Japanese isolates was classified into one of these groups. These findings also indicated that parapoxvirus infections among wild Japanese serows seem to be caused by at least two different parapoxviruses, bovine papular stomatitis virus and orf virus. The methods presented here are useful for genetic characterization and classification of parapoxviruses.The genus Parapoxvirus in the family Poxviridae has four members, orf virus (ORFV), bovine papular stomatitis virus (BPSV), pseudocowpox virus (PCPV) and parapoxvirus of red deer in New Zealand (PVNZ). Parapoxvirus infections are widespread in ruminants worldwide. Parapoxviruses generally induce mild papular dermatitis around the mouth, teats and skin of affected animals such as sheep, goats, cattle and some wild species (Esposito et al

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confidence: 99%

Genetic heterogeneity among parapoxviruses isolated from sheep, cattle and Japanese serows (Capricornis crispus)

Inoshima

Murakami

Yokoyama

et al. 2001

Journal of General Virology

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“…Moreover, both ORFV and BPSV cause pustular dermatitis in Japanese serows (Capricornis crispus) 6,7 and both ORFV and PCPV also cause papular stomatitis in Finnish reindeer (Rangifer tarandus tarandus) 19 . In addition, experimental transmission of parapoxvirus from the Japanese serow to sheep, goats and cattle has succeeded 11,13,14 . These results indicate that we can not differentiate parapoxviruses causing diseases in animals until genetic analyses are carried out.…”

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confidence: 99%

Isolation and Characterization of a Parapoxvirus from Sheep with Papular Stomatitis

Kanou

Inoshima

Shibahara

et al. 2005

JARQ

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An outbreak of papular stomatitis occurred in a sheep herd in Hokkaido, Japan. Histological examination, immunohistochemistry, electron microscopic observation, and polymerase chain reaction (PCR) were carried out. Lesions were characterized by epithelial hyperplasia, acanthosis, ballooning degeneration of the spiny layer and stratum granulosum. A parapoxvirus was isolated from the skin lesion of affected sheep and characterized genetically and antigenically. Restriction endonuclease analysis of the PCR product showed an orf virus (ORFV)-specific pattern and the isolate reacted with monoclonal antibodies against ORFV. The partially deduced amino acid sequence of the viral envelope gene was identical to those of the major Japanese ORFVs. These results indicated that the outbreak was due to infection by parapoxvirus. The isolated virus could be classified into ORFV, and was closely related to the major Japanese ORFVs, but not foreign ORFVs or other parapoxviruses.

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“…Cocirculation of BPSV and ORFV in wild ruminants has been described (35), and PPV isolates from wild ruminants have been experimentally transmitted to sheep, goats, and cattle (59,60). Both ORFV and BPSV cause occupational infections in humans with lesions characterized by large, painful nodules in the hands and, less frequently, the face (8,47,69).…”

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