Contagious caprine pleuropneumonia in Mauritius

Srivastava, Anoop Kumar; Meenowa, Deodass; Barden, G.; Salguero, Francisco J.; Churchward, Colin; Nicholas, R. A. J.

doi:10.1136/vr.c3816

Cited by 24 publications

(21 citation statements)

References 13 publications

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“…Strains belonging to each of the two evolutionary lines have been spreading in this region over the last decades and the disease has recently reached the Indian Ocean [10]. …”

Section: Discussionmentioning

confidence: 99%

“…Since the publication of these studies, very few new strains have been made available, although some of them were of particular interest. First, the isolation of Mccp in the Thrace region of Turkey in 2004 showed that there is a risk of introduction of the disease in Europe [9], and the recent outbreak of CCPP in Mauritius [10] confirmed that Mccp is spreading, threatening many disease-free areas. Furthermore, the presence of CCPP in east Asia has recently been confirmed using molecular techniques in Pakistan [11] and in Tajikistan [12] and several Chinese strains have been characterised as Mccp [13].…”

Section: Introductionmentioning

confidence: 99%

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Multi-locus sequence analysis of mycoplasma capricolum subsp. capripneumoniae for the molecular epidemiology of contagious caprine pleuropneumonia

Manso-Silván

Dupuy

Chu

et al. 2011

Vet Res

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Mycoplasma capricolum subsp. capripneumoniae (Mccp) is the causative agent of contagious caprine pleuropneumonia (CCPP), a devastating disease of domestic goats. The exact distribution of CCPP is not known but it is present in Africa and the Middle East and represents a significant threat to many disease-free areas including Europe. Furthermore, CCPP has been recently identified in Tajikistan and China. A typing method with an improved resolution based on Multi-Locus Sequence Analysis (MLSA) has been developed to trace new epidemics and to elucidate whether the recently identified cases in continental Asia were due to recent importation of Mccp. The H2 locus, a polymorphic region already in use as a molecular marker for Mccp evolution, was complemented with seven new loci selected according to the analysis of polymorphisms observed among the genome sequences of three Mccp strains. A total of 25 strains, including the two new strains from Asia, were analysed by MLSA resulting in the discrimination of 15 sequence types based on 53 polymorphic positions. A distance tree inferred from the concatenated sequences of the eight selected loci revealed two evolutionary lineages comprising five groups, which showed good correlation with geographic origins. The presence of a distinct Asian cluster strongly indicates that CCPP was not recently imported to continental Asia. It is more likely that the disease has been endemic in the area for a long time, as supported by historical clinical descriptions. In conclusion, this MLSA strategy constitutes a highly discriminative tool for the molecular epidemiology of CCPP.

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“…Strains belonging to each of the two evolutionary lines have been spreading in this region over the last decades and the disease has recently reached the Indian Ocean [10]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multi-locus sequence analysis of mycoplasma capricolum subsp. capripneumoniae for the molecular epidemiology of contagious caprine pleuropneumonia

Manso-Silván

Dupuy

Chu

et al. 2011

Vet Res

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“…In addition, serum samples were also collected from Mauritius, where CCPP has recently been identified [22]. Sixty-two herds were selected to constitute a sample representative of the whole island and 10 to 15 adult goats were randomly selected from each herd (62 herds, N = 720).…”

Section: Methodsmentioning

confidence: 99%

An international collaborative study to determine the prevalence of contagious caprine pleuropneumonia by monoclonal antibody-based cELISA

et al. 2014

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BackgroundFew serological tests are available for detecting antibodies against Mycoplasma capricolum subsp. capripneumoniae, the causal agent of contagious caprine pleuropneumonia (CCPP). The complement fixation test, the test prescribed for international trade purposes, uses a crude antigen that cross-reacts with all the other mycoplasma species of the “mycoides cluster” frequently infecting goat herds. The lack of a more specific test has been a real obstacle to the evaluation of the prevalence and economic impact of CCPP worldwide. A new competitive ELISA kit for CCPP, based on a previous blocking ELISA, was formatted at CIRAD and used to evaluate the prevalence of CCPP in some regions of Kenya, Ethiopia, Mauritius, Tajikistan and Pakistan in an international collaborative study.ResultsThe strict specificity of the test was confirmed in CCPP-free goat herds exposed to other mycoplasma species of the “mycoides cluster”. Prevalence studies were performed across the enzootic range of the disease in Africa and Asia. Seroprevalence was estimated at 14.6% in the Afar region of Ethiopia, whereas all the herds presented for CCPP vaccination in Kenya tested positive (individual seroprevalence varied from 6 to 90% within each herd). In Mauritius, where CCPP emerged in 2009, nine of 62 herds tested positive. In Central Asia, where the disease was confirmed only recently, no positive animals were detected in the Wakhan District of Afghanistan or across the border in neighboring areas of Tajikistan, whereas seroprevalence varied between 2.7% and 44.2% in the other districts investigated and in northern Pakistan. The test was also used to monitor seroconversion in vaccinated animals.ConclusionsThis newly formatted CCPP cELISA kit has retained the high specificity of the original kit. It can therefore be used to evaluate the prevalence of CCPP in countries or regions without vaccination programs. It could also be used to monitor the efficacy of vaccination campaigns as high-quality vaccines induce high rates of seroconversion.

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“…Contagious caprine pleuropneumonia (CCPP) is the most important infectious disease and causes major economic losses in goats (Ettorre et al 2007;De la Fe et al 2010;Srivastava et al 2010;Ongor et al 2011). Mycoplama infection has also been reported in wild and small ruminants (Hernandez et al 2006;Arif et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Contagious caprine pleuropneumonia in Beetal goats

Hussain

Auon

Khan

et al. 2011

Trop Anim Health Prod

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Seroprevalence, clinical findings, and lesions of contagious caprine pleuropneumonia (CCPP) in Beetal goats were recorded during an outbreak. The overall seroprevalence of CCPP was 32.50%. Confirmation of Mycoplasma mycoides in serum was carried out using counter immunoelectrophoresis (CIE) technique. The highest CIE-positive cases were recorded in the older goats (51.72%) as compared to young ones. Nasal swabs collected from 39 goats showing respiratory signs were found positive for M. mycoides. The most consistent clinical findings were mild to severe cough, purulent nasal secretion, emaciation, dyspnea, increased respiration rate, and pyrexia. Mortality due to CCPP was 9.17%. Consolidation of lungs exhibited the highest frequency (100%), followed by alveolar exudation (90.90%) and pleural adhesion (72.72%). Among the microscopic lesions, septal peribronchiolar fibrosis exhibited the highest frequency (81.81%), followed by fibrinous pleuritis (63.63%) and peribronchiolar cuffing of mononuclear cells (54.54%) in lungs. From these results, it was concluded that CCPP under subtropical conditions has high prevalence in Beetal goats and leads to significant mortality.

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Contagious caprine pleuropneumonia in Mauritius

Cited by 24 publications

References 13 publications

Multi-locus sequence analysis of mycoplasma capricolum subsp. capripneumoniae for the molecular epidemiology of contagious caprine pleuropneumonia

Multi-locus sequence analysis of mycoplasma capricolum subsp. capripneumoniae for the molecular epidemiology of contagious caprine pleuropneumonia

An international collaborative study to determine the prevalence of contagious caprine pleuropneumonia by monoclonal antibody-based cELISA

Contagious caprine pleuropneumonia in Beetal goats

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