“…Contactin, residing in the axonal membrane, brings the other proteins to the handshake. Deficiency in either caspr, contactin, or neurofascin 155 produces a disorganization of the paranodal loops and a reduction in axon conduction velocity (Bhat et al, 2001;Bonnon et al, 2007;Boyle et al, 2001;Sherman et al, 2005). At the nodal/paranodal region in the myelinated axons of sciatic nerves of mice deficient in caspr, PJBs were missing and abnormal, swollen mitochondria were observed (Einheber et al, 2006).…”