Contact sensitization to quaternium-15 acting as a warning sign for curare allergy

Osdoit, S.; Guillet, Marie-Hélène; Guillet, G.

doi:10.1111/j.1600-0536.2011.01923.x

Cited by 4 publications

(2 citation statements)

References 14 publications

(15 reference statements)

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“…To date, an extensive bibliography exists on quaternium-15 regarding its irritant effects on mammals [28,29,30,31,32,33,34,35]. Being a preservative added to various pharmaceutical, personal care products and intensely used, as the last step of its environmental fate it reaches the water environment.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Functionality and Biological Responses of Mytilus galloprovincialis after Exposure to Quaternium-15 (Methenamine 3-Chloroallylochloride)

et al. 2016

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Abstract:Although the irritant effects of quaternium-15 have been established, little is known about the toxicological consequences induced by this xenobiotic on aquatic invertebrates. The present article reports toxicological, histological and physiological effects of quaternium-15 following the exposure of Mytilus galloprovincialis for 18 days at three different concentrations (0.1, 1.0 and 2.0 mg/L). The results demonstrate that at higher concentrations histological damages to M. galloprovincialis gills occur, like melanosis, light exfoliations, increase of mucus production and infiltrative inflammation. In addition digestive gland cells of M. galloprovincialis, were not able to perform the regulation volume decrease (RVD) owing to osmotic stress following the exposure to the preservative. Overall, this first study on quaternium-15 highlights that it can jeopardize both the morphology and vital physiological processes in marine invertebrates, depending on the duration of exposure and the concentration of the preservative, indicating that further studies are necessary to increase our knowledge about the effects of this substance, commonly added to our products of daily use.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Functionality and Biological Responses of Mytilus galloprovincialis after Exposure to Quaternium-15 (Methenamine 3-Chloroallylochloride)

et al. 2016

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“…Quaternium-15 ( Figure 11) is a common contact allergen included in the European baseline series. The prevalence of contact sensitization is as low as 1.2-1.6%, but could represent the first event leading to systemic anaphylactic reaction through a switch from type IV to type I allergy [24]. Thimerosal (Figure 12), a mercuric derivative of the thiosalicylic acid, is a preservative used in several types of consumer products, including cosmetics, ophthalmic and otolaryngologic medications, and vaccines [26].…”

Section: J) Quaternium-15mentioning

confidence: 99%

Cosmetics and its Health Risks

Pereira¹,

Pereira²

2018

GJMR

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The use of cosmetic products is increasing around the world and a variety of chemical compounds used in the manufacture of these products grows at the same time. In this way, the risk of intoxication, allergic processes, prolonged chemical exposure, side effects and indiscriminate use are also increased. The present work aims to highlight the biological risks that cosmetics can pose to human health against the toxic substances used in its formulation. This work is an integrative literature review structured according to the methodology described by Whittemore, R. and Knafl, K., 2005. This work relates the main toxic chemical substances present in cosmetic products to the possible health complications reported in the scientific literature. Currently, the cosmetic industries have increased the use of compounds with preservative action, surfactant, fragrances, stains, etc. in the formulation of cosmetic products. Such substances potentiate the quality, property and shelf life of cosmetics, but on the other hand, many of these substances are toxic to the human body, presenting health risks ranging from a simple mild hypersensitivity reaction to an anaphylactic process or even a lethal intoxication. Thus, the indiscriminate use of cosmetics may present itself as an emerging issue of public health. In view of the above, this work seeks to encourage improvements in the search for new methodologies for quality control in the production and consumption of cosmetic products around the world.

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Perioperative Anaphylaxie aufgrund einer Rocuroniumallergie bei einem Kind

Wahl

Wurpts

2011

Hautarzt

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During the induction of anesthesia for strabismus correction, a six-year-old boy suffered anaphylaxis with hypotension. Midazolam, propofol, sufentanil, rocuronium, dexamethasone and ibuprofen had been administered. The boy's history failed to reveal any drug allergies. Intracutaneous testings with drugs used for anesthesia and other muscle relaxants verified a positive reaction to rocuronium as well as to cisatracurium, mivacurium, vecuronium and atracurium. There was no reaction to suxamethonium.

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Contact sensitization to quaternium-15 acting as a warning sign for curare allergy

Cited by 4 publications

References 14 publications

Evaluation of Functionality and Biological Responses of Mytilus galloprovincialis after Exposure to Quaternium-15 (Methenamine 3-Chloroallylochloride)

Evaluation of Functionality and Biological Responses of Mytilus galloprovincialis after Exposure to Quaternium-15 (Methenamine 3-Chloroallylochloride)

Cosmetics and its Health Risks

Perioperative Anaphylaxie aufgrund einer Rocuroniumallergie bei einem Kind

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