Contact sensitivity to methyl ethyl ketone peroxide in a paint sprayer

Stewart, Laine Kincaid; Beck, M. H.

doi:10.1111/j.1600-0536.1992.tb00872.x

Cited by 9 publications

(5 citation statements)

References 3 publications

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“…Our patient showed positive reactions to MEK peroxide, benzoyl peroxide, rubber chemicals and cobalt chloride, but not to the polyester resin itself. As we were unable to confirm exposure to benzoyl peroxide, there may have been cross-reactivity, as noted in a previous case (5). The positive reaction to cobalt may reflect sensitivity to accelerators such as cobalt naphthenate present within the resin at low concentrations.…”

Section: Discussioncontrasting

confidence: 50%

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Contact allergy to methyl ethyl ketone peroxide and cobalt in the manufacture of fibreglass‐reinforced plastics

1998

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Section: Discussioncontrasting

confidence: 50%

“…In a review of polyester resin dermatitis, Malten (4) stated that such reactions were no longer common. However, since that time, a further report of contact allergy to MEK peroxide in a paint sprayer has been published (5).…”

Section: Discussionmentioning

confidence: 99%

Contact allergy to methyl ethyl ketone peroxide and cobalt in the manufacture of fibreglass‐reinforced plastics

1998

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“…Even so, 5 subjects showed positive reactions to BPO, 1 of whom showed a positive reaction to MEKPO at the same time. The 2 peroxides can cross‐react in patch tests (16). Sensitization to BPO can occur from non‐occupational exposures such as exposure to adhesive tape (18), medical prostheses (19) or medical preparations for acne or ulcers (20, 21).…”

Section: Discussionmentioning

confidence: 99%

“…Unsaturated polyester (UP) resin, consisting of base resin, styrene and auxiliary chemicals, is used most often as the matrix of FRP products. Allergy to UP resin and hardening catalysts has been reported since the 1960s, but not very frequently (1–21). UP base resin is produced by esterification of di‐ or polybasic organic acid or anhydride and di‐ or polyhydric alcohol.…”

mentioning

confidence: 99%

“…Auxiliary ingredients, such as cobalt naphthenate (8–11) or dimethylaniline used as an accelerator, para‐tertiary butyl catechol (PTBC) (12, 13) or hydroquinone used as an inhibitor, and styrene (14) are more often reported as allergens than UP base resin. Hardener, whose main ingredients are methyl ethyl ketone peroxide (MEKPO) (15–17) or benzoyl peroxide (BPO) (18–21), is added to UP resin as a catalyst and often causes ICD or ACD (8). Furthermore, immediate‐type allergy due to latex in natural rubber latex (NRL) gloves has been reported as causing dermatitis in FRP workers (1).…”

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Occupational dermatoses among fibreglass‐reinforced plastics factory workers

et al. 2002

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Fibreglass-reinforced plastics (FRP) factory workers are at high risk of developing occupational dermatoses because of their exposure to many chemicals used in the manufacture of plastics as well as to glass fibre or dust. Patch tests were carried out on 29 workers involved in FRP manufacturing processes where unsaturated polyester (UP) resin was used, to investigate the causes of their skin problems. Of the 22 workers who reported experiencing skin problems, 16 showed positive results to at least 1 chemical, including 6 cases of multiple sensitivity. 2 showed positive reactions to UP base resin, 6 to cobalt chloride, 5 to benzoyl peroxide (BPO), 4 to methyl ethyl ketone peroxide (MEKPO), 2 to para-tertiary butyl catechol (PTBC), 1 to styrene and 1 to formaldehyde. After taking into account their exposures and reported causes by questionnaires and their patch test results, 7 cases were diagnosed as allergic contact dermatitis (ACD) due to chemicals, 3 as irritant contact dermatitis (ICD) due to chemicals, and 3 as dermatitis due to mechanical irritation (MI) from glass fibre or dust, as well as 9 as ACD and/or MI. 18 of the total of 29 subjects (62.1%), including 2 workers without a history of skin problems, were sensitized to at least 1 chemical. Cobalt, peroxides, PTBC and UP base resin were the common causes of ACD.

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Organic Peroxides

Muianga,

Lasee

2024

Patty's Toxicology

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Organic peroxides (ROOR′), solid or liquid with the bivalent OO structure. Relatively unstable and highly reactive molecules due to the presence of an oxygen–oxygen linkage. The oxygen–oxygen bond may be cleaved to form highly reactive free radicals and react with many substances (e.g., metals, acids, and bases). ROORs are used in plastics, rubbers, and many industries as initiators, accelerators, promoters, catalysts, activators, and more. Major concerns with ROORs are associated with fires, explosions, and corrosiveness. Reactive oxygen species and free radicals may lead to DNA damage and mutagenesis. Recent work from government agents, academic research laboratories, and manufacturing organizations have focused on physical hazards classification and categorization; and producing best practice protocols for safe handling and storage, control of temperatures, self‐accelerating decomposition temperatures, spills cleaning, disposal, and treatment of ROORs residues. These efforts allow compliance with countries and international regulations. Potential health hazards are associated with eye and skin contact, inhalation, and ingestion. Acute exposure may lead to irritation, allergic response, and potential damage to the eye and skin. As with any irritant or corrosive, dose is a critical consideration with respect to understanding the risk. Chronic exposures, mostly understood in animals but there are human data, can cause a myriad of effects. These may range from respiratory illnesses, to liver, kidney damage, and cancer. The manufacturer's SDS of individual chemical may provide toxicity information. This chapter summarizes chemical‐specific toxicity information on 77 organic peroxide compounds grouped in eight physical hazard categories. NIOSH has fully validated the method for benzoyl peroxide. NTP has released a report on the toxic effects of t ‐butyl perbenzoate and it deserves to be considered. Exposure assessment methods when available were presented. Future research needs to focus on epidemiological and toxicological studies of ROORs.

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Contact sensitivity to methyl ethyl ketone peroxide in a paint sprayer

Cited by 9 publications

References 3 publications

Contact allergy to methyl ethyl ketone peroxide and cobalt in the manufacture of fibreglass‐reinforced plastics

Contact allergy to methyl ethyl ketone peroxide and cobalt in the manufacture of fibreglass‐reinforced plastics

Occupational dermatoses among fibreglass‐reinforced plastics factory workers

Organic Peroxides

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