Contact sensitivity to gentamicin with tolerance of systemic exposure

Bellido, F. J. Muñoz; Moyano, J. C.; Mora, Álvarez; Juan, J; Bellido, J.

doi:10.1111/j.1398-9995.1996.tb04462.x

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Overall, allergic reactions to aminoglycosides reported in the literature are rare. Aminoglycosides come in multiple dosage forms, including topical, parenteral, and inhaled, and there have been reports of reactions from each dosage form, some being localized reactions, and others being systemic reactions [30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59]. Below and in Table 2, Table 3 and Table 4 is a summary of the reactions caused by gentamicin, tobramycin, and amikacin.…”

Section: Documented Allergic Reactionsmentioning

confidence: 99%

“…The most frequently reported type of allergic reaction for gentamicin, tobramycin, and amikacin was cutaneous, and the reactions were caused by a variety of dosage forms (Table 2). For gentamicin, there were reports of allergic dermatitis, contact sensitivity, ulcerative dermatitis, urticaria, rash, and exfoliative erythroderma [30,31,32,33,34,35,36,37,38,39,40]. Reported cutaneous reactions with tobramycin included contact dermatitis, exfoliative dermatitis, rash, urticaria, toxic epidermal necrosis (given concomitantly with meropenem), Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome (given concomitantly with piperacillin/tazobactam), and fixed exanthema [40,41,42,43,44,45,46,47,48].…”

Section: Documented Allergic Reactionsmentioning

confidence: 99%

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Aminoglycoside Allergic Reactions

et al. 2019

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Aminoglycosides are antimicrobial agents that are primarily used for infections caused by Gram-negative pathogens. The purpose of this article is to review the allergic reactions reported in the published literature to aminoglycoside antibiotics. A thorough PubMed search was conducted and excluded non-allergic adverse reactions to aminoglycosides. Allergic reactions to aminoglycosides occur infrequently, but can include cutaneous reactions as well as systemic reactions, including anaphylaxis. Of the evaluated aminoglycosides, gentamicin had the most reported allergic reactions, including the most reports of anaphylaxis, followed by tobramycin, and then amikacin. Most reports of allergic reactions occurred in patients who had a prior exposure to some dosage form of an aminoglycoside. Cross-reactivity among aminoglycosides is common and occurs due to the similarities in their chemical structures. Desensitization protocols to tobramycin have been described in the literature.

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Section: Documented Allergic Reactionsmentioning

confidence: 99%

Section: Documented Allergic Reactionsmentioning

confidence: 99%

Aminoglycoside Allergic Reactions

et al. 2019

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Consensus document on the approach to children with allergic reactions after vaccination or allergy to vaccine components

Echeverría-Zudaire

Castillo

Alonso-Lebrero

et al. 2015

Allergologia et Immunopathologia

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Vaccinations are one of the main public health tools for the control of vaccine-preventable diseases. If a child is identified as having had an allergic reaction to a vaccine, subsequent immunisations will probably be suspended - with the risks such a decision implies. The incidence of severe allergic reactions is very low, ranging between 0.5 and 1 cases/100,000 doses. Rather than the vaccine antigens as such, the causes of allergic reactions to vaccines are often residual protein components of the manufacturing process such as gelatine or egg, and less commonly yeasts or latex. Most vaccine reactions are mild and circumscribed to the injection site; although in some cases severe anaphylactic reactions can be observed. If an immediate-type allergic reaction is suspected at vaccination, or if a child with allergy to some of the vaccine components is scheduled for vaccination, a correct diagnosis of the possible allergic process must be made. The usual vaccine components must be known in order to determine whether vaccination can be safely performed.

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