1990
DOI: 10.1001/archderm.126.9.1173
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Contact sensitivity to dinitrochlorobenzene is impaired in atopic subjects. Controversy revisited

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Cited by 37 publications
(37 citation statements)
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“…22,25 Newell et al 26 recently reported attenuated responses to DNCB and T H 2 skewing (with decreased IFN-g and increased IL-4 levels) in normalappearing skin from atopic compared with healthy subjects. The T H 2-polarized responses were independent of filaggrin (FLG) mutation status, 27 which is consistent with the lack of association between ACD and FLG mutations in most studies. 26,28,29 Past studies did not address the role of AD skin phenotype in influencing cutaneous allergic responses.…”
supporting
confidence: 68%
See 1 more Smart Citation
“…22,25 Newell et al 26 recently reported attenuated responses to DNCB and T H 2 skewing (with decreased IFN-g and increased IL-4 levels) in normalappearing skin from atopic compared with healthy subjects. The T H 2-polarized responses were independent of filaggrin (FLG) mutation status, 27 which is consistent with the lack of association between ACD and FLG mutations in most studies. 26,28,29 Past studies did not address the role of AD skin phenotype in influencing cutaneous allergic responses.…”
supporting
confidence: 68%
“…Although previous studies have suggested that the ACD response might be attenuated in patients with AD, 25,27 these studies focused on immune responses in peripheral blood, which might not be representative of skin, [43][44][45][46] or on clinically irrelevant sensitizers, such as DNCB. 27 Recently, Newell et al 26 demonstrated an attenuated hypersensitivity reaction and T H 2 skewing in nonlesional AD versus healthy skin by using a strong hapten (DNCB), suggesting that the characteristic immune phenotype of background AD skin contributes to the distinct T H 2 polarization on challenge. 27 Although DNCB is a useful model to study hypersensitivity reactions, it has universal sensitization potential; alternatively, exposure to common allergens might be more significantly influenced by the genetic background that leads to barrier defects in patients with AD.…”
Section: Discussionmentioning
confidence: 99%
“…This is consistent with older studies showing that patients with atopic dermatitis with active dermatitis may be harder to sensitize to strong allergens. 6 More research is needed to identify the patch tests of highest value to specific patient cohorts.…”
Section: Discussionmentioning
confidence: 99%
“…5 Atopic dermatitis patients seem to be less susceptible to strong sensitizers such as poison ivy and are harder to sensitize to the potent allergen dinitrochlorobenzene. 6 There may be a tipping point at which damage to the epidermis no longer enhances cutaneous sensitization via dangerassociated molecular patterns but rather is of sufficient severity that cutaneous sensitization does not occur. This may explain the decreased prevalence of positive patch test findings in patients with severe atopic dermatitis that is not seen in patients with moderate or mild disease.…”
mentioning
confidence: 99%
“…In early studies, contact sensitivity to dinitrochlorobenzene (DNCB) in patients with AD was less than in control subjects [14] and severity of AD was inversely associated with contact sensitization. DNCB sensitization was positive in 33 % of severe, 95 % of moderate, and 100 % of mild AD patients [15].…”
Section: Prevalence Of Allergic Contact Dermatitis (Acd) In Atopic Dementioning
confidence: 99%