Abstract:Conventional methods for measuring cardiovascular parameters use skin contact techniques requiring a measuring device to be worn by the user. To avoid discomfort of contact devices, camera-based techniques using photoplethysmography have been recently introduced. Nevertheless, these solutions are typically expensive and difficult to be used daily at home. In this work, we propose an innovative solution for monitoring cardiovascular parameters that is low cost and can be easily integrated within any common home… Show more
“…Of course, handwriting-based intelligent systems are not expected to replace standard techniques or even doctors but rather to provide additional evidence to further support the clinical assessment. Intelligent systems technology is proving beneficial in a number of health domains, also including neuroimaging [111] and cardiovascular risk assessment [112].…”
Studying the effects of neurodegeneration on handwriting has emerged as an interdisciplinary research topic and has attracted considerable interest from psychologists to neuroscientists and from physicians to computer scientists. The complexity of handwriting, in fact, appears to be sensitive to age-related impairments in cognitive functioning; thus, analyzing handwriting in elderly people may facilitate the diagnosis and monitoring of these impairments. A large body of knowledge has been collected in the last thirty years thanks to the advent of new technologies which allow researchers to investigate not only the static characteristics of handwriting but also especially the dynamic aspects of the handwriting process. The present paper aims at providing an overview of the most relevant literature investigating the application of dynamic handwriting analysis in neurodegenerative disease assessment. The focus, in particular, is on Parkinon’s disease (PD) and Alzheimer’s disease (AD), as the two most widespread neurodegenerative disorders. More specifically, the studies taken into account are grouped in accordance with three main research questions: disease insight, disease monitoring, and disease diagnosis. The net result is that dynamic handwriting analysis is a powerful, noninvasive, and low-cost tool for real-time diagnosis and follow-up of PD and AD. In conclusion of the paper, open issues still demanding further research are highlighted.
“…Of course, handwriting-based intelligent systems are not expected to replace standard techniques or even doctors but rather to provide additional evidence to further support the clinical assessment. Intelligent systems technology is proving beneficial in a number of health domains, also including neuroimaging [111] and cardiovascular risk assessment [112].…”
Studying the effects of neurodegeneration on handwriting has emerged as an interdisciplinary research topic and has attracted considerable interest from psychologists to neuroscientists and from physicians to computer scientists. The complexity of handwriting, in fact, appears to be sensitive to age-related impairments in cognitive functioning; thus, analyzing handwriting in elderly people may facilitate the diagnosis and monitoring of these impairments. A large body of knowledge has been collected in the last thirty years thanks to the advent of new technologies which allow researchers to investigate not only the static characteristics of handwriting but also especially the dynamic aspects of the handwriting process. The present paper aims at providing an overview of the most relevant literature investigating the application of dynamic handwriting analysis in neurodegenerative disease assessment. The focus, in particular, is on Parkinon’s disease (PD) and Alzheimer’s disease (AD), as the two most widespread neurodegenerative disorders. More specifically, the studies taken into account are grouped in accordance with three main research questions: disease insight, disease monitoring, and disease diagnosis. The net result is that dynamic handwriting analysis is a powerful, noninvasive, and low-cost tool for real-time diagnosis and follow-up of PD and AD. In conclusion of the paper, open issues still demanding further research are highlighted.
“…Novel insights could be obtained, for example, by using a multi-expert approach or a set of fuzzy inference rules. Promising results from using these techniques for diagnostic purposes in other domains have been recently reported, e.g., [52,53]. A multi-expert approach, which is based on ensembling different classifiers trained for the same task, may further improve prediction accuracy, as it can benefit from the different viewpoints from which these classifiers may look at the data.…”
Signal processing and machine learning techniques are changing the clinical practice based on medical imaging from many perspectives. A major topic is related to (i) the development of computer aided diagnosis systems to provide clinicians with novel, non-invasive and low-cost support-tools, and (ii) to the development of new methodologies for the analysis of biomedical data for finding new disease biomarkers. Advancements have been recently achieved in the context of Alzheimer’s disease (AD) diagnosis through the use of diffusion weighted imaging (DWI) data. When combined with tractography algorithms, this imaging modality enables the reconstruction of the physical connections of the brain that can be subsequently investigated through a complex network-based approach. A graph metric particularly suited to describe the disruption of the brain connectivity due to AD is communicability. In this work, we develop a machine learning framework for the classification and feature importance analysis of AD based on communicability at the whole brain level. We fairly compare the performance of three state-of-the-art classification models, namely support vector machines, random forests and artificial neural networks, on the connectivity networks of a balanced cohort of healthy control subjects and AD patients from the ADNI database. Moreover, we clinically validate the information content of the communicability metric by performing a feature importance analysis. Both performance comparison and feature importance analysis provide evidence of the robustness of the method. The results obtained confirm that the whole brain structural communicability alterations due to AD are a valuable biomarker for the characterization and investigation of pathological conditions.
“…Job index k [ 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30 ] Job priority p k [ 30,29,28,27,26,25,24,23,22,21,20,19,18,17,16,15,14,13,12,11,10,9,8,…”
Section: Description Symbol Valuementioning
confidence: 99%
“…In a recent study, Bartolini et al introduced the term "green warehousing" (GW) to denote a managerial concept integrating and implementing environmentally friendly operations with the objective of minimizing the energy consumption, energy cost, and GHG emissions of a emissions of a warehouse [3]. The development of GW approaches is also favored by the decreasing costs of smart devices [4], the large availability of distributed sensors [5] and data analytics tools [6], and, in general, advances of information and communication technologies (ICTs) [7]. The results of recent market surveys show that a sustainable approach to warehouse management allows brand fidelity and stakeholder satisfaction to be increased, as well as improving the ability of companies to quickly and flexibly respond to market changes [8].…”
In recent years, the continuous increase of greenhouse gas emissions has led many companies to investigate the activities that have the greatest impact on the environment. Recent studies estimate that around 10% of worldwide CO2 emissions derive from logistical supply chains. The considerable amount of energy required for heating, cooling, and lighting as well as material handling equipment (MHE) in warehouses represents about 20% of the overall logistical costs. The reduction of warehouses’ energy consumption would thus lead to a significant benefit from an environmental point of view. In this context, sustainable strategies allowing the minimization of the cost of energy consumption due to MHE represent a new challenge in warehouse management. Consistent with this purpose, a two-step optimization model based on integer programming is developed in this paper to automatically identify an optimal schedule of the material handling activities of electric mobile MHEs (MMHEs) (i.e., forklifts) in labor-intensive warehouses from profit and sustainability perspectives. The resulting scheduling aims at minimizing the total cost, which is the sum of the penalty cost related to the makespan of the material handling activities and the total electricity cost of charging batteries. The approach ensures that jobs are executed in accordance with priority queuing and that the completion time of battery recharging is minimized. Realistic numerical experiments are conducted to evaluate the effects of integrating the scheduling of electric loads into the scheduling of material handling operations. The obtained results show the effectiveness of the model in identifying the optimal battery-charging schedule for a fleet of electric MMHEs from economic and environmental perspectives simultaneously.
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