Contact Lenses for Color Vision Deficiency

Elsherif, Mohamed; Salih, Ahmed E.; Yetisen, Ali K.; Butt, Haider

doi:10.1002/admt.202000797

Cited by 22 publications

(27 citation statements)

References 14 publications

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“…[21] However, ophthalmic wearables, which utilize dyed customized filters to alter the wavelength of the colors perceived by the patients' eyes, have recently gained massive attention. [21,[25][26][27][28][29] These wearables operate on a principle, introduced by Seebeck, [30] who noted that patients' photoreceptor cones are simulated individually rather than simultaneously when they look through a red and green filter, consecutively. Utilizing the latter concept, companies manufactured glasses and contact lenses as wearable aids for CVD patients.…”

Section: Ophthalmic Wearable Aids For Cvd Patientsmentioning

confidence: 99%

Silver Nanoparticle‐Loaded Contact Lenses for Blue‐Yellow Color Vision Deficiency

Salih

Shanti

Elsherif

et al. 2021

Physica Status Solidi (a)

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Contact lenses can be functionalized to offer advanced capabilities transcending their primary applications in vision correction and cosmetics. Herein, 40 and 60 nm spherical silver nanoparticles (SNPs) are integrated within poly(2‐hydroxyethyl methacrylate) (pHEMA) contact lenses toward fabrication of SNP‐loaded contact lenses with excellent optical and material properties as wearables for blue‐yellow color vision deficiency (CVD) patients. The morphology and optical properties of the SNPs are characterized prepolymerization using the transmission electron microscopy (TEM) and an optical spectrophotometer. Then, the transmission spectra of the SNP‐loaded contact lenses at different concentrations along with the wettability and water content are measured, to demonstrate the effect of NPs’ addition on the lenses’ optical and material characteristics. Results indicate that the transmission spectra of SNP‐loaded contact lenses, with optimum concentrations, filter out problematic wavelengths of visible light (485–495 nm), which will facilitate better color distinction for blue‐yellow CVD patients. The contact lenses’ optical properties are analogous to the commercial colorblind glasses, indicating their effectiveness as color filtering wearables. Finally, the cytobiocompatability analysis of the contact lenses to RAW 264.7 culture of cells shows that they are biocompatible, and the cell viability remains higher than 75% after 24 h in contact with the lenses.

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Section: Ophthalmic Wearable Aids For Cvd Patientsmentioning

confidence: 99%

Silver Nanoparticle‐Loaded Contact Lenses for Blue‐Yellow Color Vision Deficiency

Salih

Shanti

Elsherif

et al. 2021

Physica Status Solidi (a)

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“…However, the stability of the dyes within the contact lenses is yet to be improved. In fact, it was shown that the dyes’ effectiveness was reduced by 40% after 1 day due to their leakage from the lenses. , Also lately, smart glasses developed by companies, like Google, have been incorporated into CVD research. , Researchers used these wearables to actively filter and recolor the vision of the patients using image processing algorithms; however, the drawback of such glasses is their bulk size, which makes them impractical for daily use.…”

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confidence: 99%

Gold Nanocomposite Contact Lenses for Color Blindness Management

et al. 2021

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Color vision deficiency (CVD) is an ocular congenital disorder that affects 8% of males and 0.5% of females. The most prevalent form of color vision deficiency (color blindness) affects protans and deutans and is more commonly known as “red–green color blindness”. Since there is no cure for this disorder, CVD patients opt for wearables that aid in enhancing their color perception. The most common wearable used by CVD patients is a form of tinted glass/lens. Those glasses filter out the problematic wavelengths (540–580 nm) for the red–green CVD patients using organic dyes. However, few studies have addressed the fabrication of contact lenses for color vision deficiency, and several problems related to their effectiveness and toxicity were reported. In this study, gold nanoparticles are integrated into contact lens material, thus forming nanocomposite contact lenses targeted for red–green CVD application. Three distinct sets of nanoparticles were characterized and incorporated with the hydrogel material of the lenses (pHEMA), and their resulting optical and material properties were assessed. The transmission spectra of the developed nanocomposite lenses were analogous to those of the commercial CVD wearables, and their water retention and wettability capabilities were superior to those in some of the commercially available contact lenses used for cosmetic/vision correction purposes. Hence, this work demonstrates the potential of gold nanocomposite lenses in CVD management and, more generally, color filtering applications.

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“…Recently, researchers have developed contact lenses that cross-link with selected dyes or nanoparticles to block out the wavelengths (540-580 nm) that create issues for people with red-green CVD. 56,57 Overall, contact lenses involved in continuous tear film sampling, and some functionalized contact lens sensors have many potential applications for disease diagnostics and treatment.…”

Section: Advances In Contact Lens Sensorsmentioning

confidence: 99%