Contact lenses fitting after intracorneal ring segments implantation in keratoconus

Moreira, Luciane Bugmann; Bardal, Ricardo Augustho Canto; Crisigiovanni, Leila Roberta

doi:10.1590/s0004-27492013000400004

Cited by 19 publications

(11 citation statements)

References 15 publications

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“…Keratoconus (KC) is a relatively common [ 1 , 2 ] bilateral [ 1 , 3 – 21 ] corneal disease that is accompanied by corneal ectasia [ 1 , 3 , 4 , 6 , 9 , 10 , 13 – 19 , 21 – 46 ] which usually progresses asymmetrically [ 1 , 5 , 9 , 11 – 13 , 15 , 17 – 19 , 30 , 31 , 33 , 38 , 39 , 45 ]. Its main clinical manifestation is thinning and protrusion of the cornea [ 1 , 2 , 4 – 6 , 10 , 13 – 17 , 19 – 22 , 25 – 34 , 36 – 44 , 47 – 58 ], which assumes a conical shape [ 1 , 2 , 4 , 13 , 15 – 19 , 27 , 29 – 31 , 33 , 34 , 36 – 40 , 42 , 44 , 47 , 48 , 51 , 55 , 56 , 58 , 59 ]. These characteristics, even in the absence of clinically manifest KC, are also major risk factors for the condition [ 60 , 61 ]; depending on the stage of the disease, KC presents with a variety of clin...…”

Section: Introductionmentioning

confidence: 99%

Genetic Aspects of Keratoconus: A Literature Review Exploring Potential Genetic Contributions and Possible Genetic Relationships with Comorbidities

Loukovitis¹,

Sfakianakis

Syrmakesi

et al. 2018

Ophthalmol Ther

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IntroductionKeratoconus (KC) is a complex, genetically heterogeneous, multifactorial degenerative disorder that is accompanied by corneal ectasia which usually progresses asymmetrically. With an incidence of approximately 1 per 2000 and 2 cases per 100,000 population presenting annually, KC follows an autosomal recessive or dominant pattern of inheritance and is, apparently, associated with genes that interact with environmental, genetic, and/or other factors. This is an important consideration in refractive surgery in the case of familial KC, given the association of KC with other genetic disorders and the imbalance between dizygotic twins. The present review attempts to identify the genetic loci contributing to the different KC clinical presentations and relate them to the common genetically determined comorbidities associated with KC.MethodsThe PubMed, MEDLINE, Google Scholar, and GeneCards databases were screened for KC-related articles published in English between January 2006 and November 2017. Keyword combinations of “keratoconus,” “risk factor(s),” “genetics,” “genes,” “genetic association(s),” and “cornea” were used. In total, 217 articles were retrieved and analyzed, with greater weight placed on the more recent literature. Further bibliographic research based on the 217 articles revealed another 124 relevant articles that were included in this review. Using the reviewed literature, an attempt was made to correlate genes and genetic risk factors with KC characteristics and genetically related comorbidities associated with KC based on genome-wide association studies, family-based linkage analysis, and candidate-gene approaches.ResultsAn association matrix between known KC-related genes and KC symptoms and/or clinical signs together with an association matrix between identified KC genes and genetically related KC comorbidities/syndromes were constructed.ConclusionTwenty-four genes were identified as potential contributors to KC and 49 KC-related comorbidities/syndromes were found. More than 85% of the known KC-related genes are involved in glaucoma, Down syndrome, connective tissue disorders, endothelial dystrophy, posterior polymorphous corneal dystrophy, and cataract.

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Section: Introductionmentioning

confidence: 99%

Genetic Aspects of Keratoconus: A Literature Review Exploring Potential Genetic Contributions and Possible Genetic Relationships with Comorbidities

Loukovitis¹,

Sfakianakis

Syrmakesi

et al. 2018

Ophthalmol Ther

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“…It should be noted that after ICRS implantation there are still patients who need some type of visual correction to improve their eyesight [7][8][9][10]. Nonsurgical options to improve vision after ICRS implantation include different types of contact lenses, such as conventional or customised soft lenses and rigid gas-permeable (RGP; corneal, corneo-scleral and scleral) lenses, hybrid lenses and a piggyback contact lens system [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. An advantage of RGP lenses is that they are able to mask corneal surface irregularities with the tear layer between the lens and anterior corneal surface, and they also provide a regular refractive surface [27,28].…”

Section: Introductionmentioning

confidence: 99%

Visual quality with corneo-scleral contact lenses after intracorneal ring segment (ICRS) implantation for keratoconus management

Montalt

Porcar

España‐Gregori

et al. 2019

Contact Lens and Anterior Eye

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“…Keratoconus (KC) is a progressive degeneration, thinning, and anterior protrusion of the cornea that results in myopia and irregular astigmatism, leading to low vision (Moreira et al, 2013). The prevalence of KC varies among different ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

“…High concordance in monozygotic twins and a significantly higher prevalence of KC in first-degree relatives of KC patients, than in the general population, both indicate a genetic basis for the disease (Wang et al, 2000). Around 6-23% of the KC patients exhibit a family history with an autosomal dominant or recessive pattern of inheritance (Moreira et al, 2013). KC may also coexist with several rare genetic disorders, including atopy, vernal keratoconjunctivitis, retinitis pigmentosa, Leber congenital amaurosis, mitral valve prolapse, Down syndrome, and noninflammatory connective tissue disorders, such as Ehlers-Danlos syndrome, osteogenesis imperfecta, and joint hypermobility (Rabinowitz, 1998;McGhee, 2009).…”

Section: Introductionmentioning

confidence: 99%

Novel visual system homeobox 1 gene mutations in Turkish patients with keratoconus

et al. 2016

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The aim of this study was to screen the visual system homeobox 1 (VSX1) gene in Turkish patients with keratoconus (KC). The patient group consisted of 44 patients who had undergone corneal transplant surgery before the age of 30, for advanced and rapidly progressive KC. The control group comprised 250 healthy individuals. We detected two missense mutations, D144N and D295Y, in exon 2 and exon 5 of the VSX1 gene, respectively, using next-generation sequencing analysis. The pathologic effects of the D144N and D295Y missense mutations on protein function were determined with bioinformatic analysis tools, SIFT, PolyPhen, and MutationTaster. Aspartic acid at the 144th position was more preserved among species than aspartic acid at the 295th position of the VSX1 protein. In the control group, five different genetic variations were detected, two of which (rs8123716 and rs12480307) were synonymous with variations in the patient group. Our results suggested that the D144N and D295Y mutations might have a role in the pathogenesis of KC disease.

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Contact lenses fitting after intracorneal ring segments implantation in keratoconus

Abstract: Contact lens fitting after intracorneal ring is possible, provides good comfort, improves visual acuity, and therefore, may postpone the need for penetrating keratoplasty.

Cited by 19 publications

References 15 publications

Genetic Aspects of Keratoconus: A Literature Review Exploring Potential Genetic Contributions and Possible Genetic Relationships with Comorbidities

Genetic Aspects of Keratoconus: A Literature Review Exploring Potential Genetic Contributions and Possible Genetic Relationships with Comorbidities

Visual quality with corneo-scleral contact lenses after intracorneal ring segment (ICRS) implantation for keratoconus management

Novel visual system homeobox 1 gene mutations in Turkish patients with keratoconus

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