Contact Lens Sensor with Anti-jamming Capability and High Sensitivity for Intraocular Pressure Monitoring

Ren, Xueyang; Zhou, Yunfan; Lu, Fangzhou; Zhai, Leili; Wu, Hao; Chen, Zhongda; Wang, Changxian; Zhu, Xujun; Xie, Yandong; Cai, Pingqiang; Xu, Jing; Tang, Xianglong; Li, Jianqing; Ye, Jin; Jiang, Qin; Hu, Benhui

doi:10.1021/acssensors.3c00542

Cited by 12 publications

(19 citation statements)

References 54 publications

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“…The high density of nanowires enabled the device to acquire image patterns with high resolution, demonstrating the basic function of the human eye. Additionally, customized eye-monitoring is another theme for soft robotics application …”

Section: Case Studies and Testbeds Of Ldn-based Soft Wearable Electro...mentioning

confidence: 99%

Materials-Driven Soft Wearable Bioelectronics for Connected Healthcare

Gong,

Lu,

Yin

et al. 2024

Chem. Rev.

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In the era of Internet-of-things, many things can stay connected; however, biological systems, including those necessary for human health, remain unable to stay connected to the global Internet due to the lack of soft conformal biosensors. The fundamental challenge lies in the fact that electronics and biology are distinct and incompatible, as they are based on different materials via different functioning principles. In particular, the human body is soft and curvilinear, yet electronics are typically rigid and planar. Recent advances in materials and materials design have generated tremendous opportunities to design soft wearable bioelectronics, which may bridge the gap, enabling the ultimate dream of connected healthcare for anyone, anytime, and anywhere. We begin with a review of the historical development of healthcare, indicating the significant trend of connected healthcare. This is followed by the focal point of discussion about new materials and materials design, particularly low-dimensional nanomaterials. We summarize material types and their attributes for designing soft bioelectronic sensors; we also cover their synthesis and fabrication methods, including top-down, bottom-up, and their combined approaches. Next, we discuss the wearable energy challenges and progress made to date. In addition to front-end wearable devices, we also describe back-end machine learning algorithms, artificial intelligence, telecommunication, and software. Afterward, we describe the integration of soft wearable bioelectronic systems which have been applied in various testbeds in real-world settings, including laboratories that are preclinical and clinical environments. Finally, we narrate the remaining challenges and opportunities in conjunction with our perspectives.

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Section: Case Studies and Testbeds Of Ldn-based Soft Wearable Electro...mentioning

confidence: 99%

Materials-Driven Soft Wearable Bioelectronics for Connected Healthcare

Gong,

Lu,

Yin

et al. 2024

Chem. Rev.

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“…[68] To effectively reduce blinking-induced noise interference, many previous studies have attempted to reduce the surface coefficient of friction by attaching a lubricant to the contact lens surface. [69] However, this method is rather impractical due to the expensive costs, sophisticated production process, rapid drainage of lubricant, and ocular irritation. Ren et al (Figure 7) resolved the aforementioned issues by creating contact lens sensors with anti-jamming ability.…”

Section: Iop Monitoringmentioning

confidence: 99%

“…Ren et al (Figure 7) resolved the aforementioned issues by creating contact lens sensors with anti-jamming ability. [69] Inspired by fish skin, the researchers implemented a self-lubricating layer, made of HEMA/PDMS hybrid, into the sensor that can reduce the surface coefficient of friction. Consequently, this significantly enhances the sensor's ability to filter out noise interference and exhibits high sensitivity to IOP signals.…”

Section: Iop Monitoringmentioning

confidence: 99%

See 1 more Smart Citation

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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“…Recently, propelled by the urgent demand for advanced artificial intelligence and wearable medical devices, flexible wearable devices have attracted considerable attention due to their lightweight and portability. 19–25 They enable continuous monitoring of physiological signals, thus supporting clinical decisions and enhancing the management of mental health disorders. 26–29 For example, electroencephalogram (EEG) electrodes are developed for prolonged high-quality neurological state monitoring.…”

Section: Introductionmentioning

confidence: 99%