Contact Lens Materials: A Materials Science Perspective

Musgrave, Christopher S. A.; Fang, Fengzhou

doi:10.3390/ma12020261

Cited by 222 publications

(217 citation statements)

References 192 publications

(242 reference statements)

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“…Consistent development and evolution of new contact lens materials have been observed throughout the last century [1,2]. Considering the mechanical properties of these new materials is vital for sufficient functionality of the soft contact lenses [3].…”

Section: Introductionmentioning

confidence: 99%

Simulation of the Effect of Material Properties on Soft Contact Lens On-Eye Power

et al. 2019

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Purpose: To evaluate the variation in the optical power achieved following soft contact lens eye fitting for spherical and cylindrical lenses with differing hydrogel material properties. Methods: Uniaxial tensile tests were performed on four hydrogel materials 77% water-content (w-c) hydrogel, 74% w-c blue silicone hydrogel, 74% w-c clear silicone hydrogel, and 64% w-c clear hydrogel (shortly referred to as H77p0, SiH74p5-blue, SiH74p5-clear, and H64p0-clear), under loading conditions that would be expected in vivo. Finite element models of the cornea and contact lens interaction were generated using spherical and cylindrical lenses with powers varying from −10 to +20 D; overall diameters of either 13.5, 14.0, or 14.5 mm; and with material properties matching those determined through experimental testing. Results: The moduli of elasticity for each of the tested hydrogel materials were 0.195 ± 0.027 MPa, 0.277 ± 0.019 MPa, 0.279 ± 0.01 MPa, and 0.457 ± 0.013 MPa for H77p0, SiH74p5-blue, SiH74p5-clear, and H64p0 respectively. The calculated values of effective power change (EPC) showed strong negative correlations with lens power. This was particularly apparent in the higher end of the lens power spectrum (over +5 D), where each of the materials demonstrated a highly linear reduction in EPC with increased lens power. Conclusions: Soft contact lenses composed of a stiffer hydrogel are far more resilient to changes in EPC across the lower end of the lens power spectrum (−10 to +5 D). Beyond this range, the material choice does not have a significant effect on the EPC.

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Section: Introductionmentioning

confidence: 99%

Simulation of the Effect of Material Properties on Soft Contact Lens On-Eye Power

et al. 2019

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“…High wettability of contact lenses has been linked to better comfort. [ 14 ] The hydrophilic nature of the pεK hydrogels is likely due to the presence of many polar amine groups on the materials surface, as well the high water content of hydrogels. Both pεK hydrogels had a high water content similar to commercially available contact lenses, [ 15 ] 71.8% ± 1.5 and 68.5% ± 5.8 for 60%0.1 and 60%0.13, respectively ( p = 0.38; Figure 1b).…”

Section: Figurementioning

confidence: 99%

Poly‐ε‐Lysine or Mel4 Antimicrobial Surface Modification on a Novel Peptide Hydrogel Bandage Contact Lens

Lace

Doherty

Dutta

et al. 2020

Adv Materials Inter

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Microbial keratitis (MK) is a serious issue in many countries and is often caused by contact lens wear. Antimicrobial peptides (AMPs) are a potentially useful tool for creating antimicrobial surfaces in light of increasing antibiotic resistance. Poly‐ε‐lysine (pεK) is an AMP that has been used extensively as a food preservative and Mel4 has recently been synthesized and studied as an antimicrobial coating for contact lenses. A hydrogel synthesized of pεK cross‐linked with biscarboxylic acids provides a potential lens material which has many surface free amines, that can be subsequently used to attach additional AMPs, creating an antimicrobial lens. The aim of this study is to investigate pεK hydrogels against a clinical strain of Pseudomonas aeruginosa (P. aeruginosa) for preventing or treating MK. Covalent attachment of AMPs is investigated and confirmed by fluorescently tagged peptides. Bound pεK effectively reduces the number of adherent P. aeruginosa in vitro (>3 log). In ex vivo studies positive antimicrobial activity is observed on bare pεK hydrogels and those with additionally bound pεK or Mel4; lenses allow the maintenance of the corneal epithelium. A pεK hydrogel contact lens with additional AMPs can be a therapeutic tool to reduce the incidence of MK.

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“…The selection of polymers or materials used in contact lens manufacturing comes in two categories: organic glass (polymeric material or optical plastics) and (Musgrave and Fang, 2019). In the following text we discuss the development and improvement of polymers used in optical applications in terms of permeability, refraction and dispersion properties.…”

Section: Polymers With High Refractive Index and High Abbe Numbermentioning

confidence: 99%

Contact lens, high refractive index, abbe number, hybrid materials, fabrication, enhancement

Al-Hamdani¹,

Shaker²,

Al-Amiery³

2019

J. Eng. Appl. Sci.

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An overview of high Refractive Index (RI), high abbe number (low dispersion) (ν d) and high transmissivity optical plastics improved and used to get a perfect Contact Lens (CL) material and design, this review gathers optical plastics developments to choose the desired polymer in Cls applications. High performance CLs can be made of polymers with high transparency nanocomposites because of the need for optical plastic merits such as light weight, transparency, biocompatibility, the ability to modify its refractive index and Abbe number. Doping with nano-particles can be considered as a good candidate in CLs fabrication due to its rule in increasing the RI, ν d and light transmittance higher. This study shows the evolution of polymer properties used in optical applications and focuses on RI, ν d and transparency of the optical plastics that can be employed in the CLs fabrication or enhancement of them.

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Contact Lens Materials: A Materials Science Perspective

Cited by 222 publications

References 192 publications

Simulation of the Effect of Material Properties on Soft Contact Lens On-Eye Power

Simulation of the Effect of Material Properties on Soft Contact Lens On-Eye Power

Poly‐ε‐Lysine or Mel4 Antimicrobial Surface Modification on a Novel Peptide Hydrogel Bandage Contact Lens

Contact lens, high refractive index, abbe number, hybrid materials, fabrication, enhancement

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