Contact focusing multimodal microprobes for ultraprecise laser tissue surgery

Darafsheh, Arash; Fardad, Amir; Fried, Nathaniel M.; Antoszyk, Andrew N.; Ying, Howard S.; Astratov, Vasily N.

doi:10.1364/oe.19.003440

Cited by 68 publications

(38 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Modeling has shown that the spot size will decrease if the sphere diameters are reduced and if all the spheres are the same diameter, including the end sphere. 31 We chose a slightly larger end sphere for this study for its ease of assembly, but it should be possible to fix and seal a smaller sphere at the HWG tip with more precise methods. Also for a practical device the internal spheres will have to be fixed in some way.…”

Section: Discussionmentioning

confidence: 99%

“…Geometrical ray trace simulations have shown that chains of spheres with a refractive index close to 1.7 provide the smallest spatial beam width at the surface of the end sphere. 31 Sapphire is also biocompatible, has a high phase transition temperature, and a high laser damage threshold. The spheres used had tight diameter tolerances and a low number of inclusions.…”

Section: Microsphere Scalpel Designmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of novel microsphere chain fiber optic tips for potential use in ophthalmic laser surgery

Hutchens

Darafsheh²,

Fardad³

et al. 2012

J. Biomed. Opt.

Self Cite

View full text Add to dashboard Cite

Abstract. Ophthalmic surgery may benefit from use of more precise fiber delivery systems during laser surgery. Some current ophthalmic surgical techniques rely on tedious mechanical dissection of tissue layers. In this study, chains of sapphire microspheres integrated into a hollow waveguide distal tip are used for erbium:YAG laser ablation studies in contact mode with ophthalmic tissues, ex vivo. The laser's short optical penetration depth combined with the small spot diameters achieved with this fiber probe may provide more precise tissue removal. One-, three-, and five-microsphere chain structures were characterized, resulting in FWHM diameters of 67, 32, and 30 μm in air, respectively, with beam profiles comparable to simulations. Single Er:YAG pulses of 0.1 mJ and 75-μs duration produced ablation craters with average diameters of 44, 30, and 17 μm and depths of 26, 10, and 8 μm, for one-, three-, and five-sphere structures, respectively. Microsphere chains produced spatial filtering of the multimode Er:YAG laser beam and fiber, providing spot diameters not otherwise available with conventional fiber systems. Because of the extremely shallow treatment depth, compact focused beam, and contact mode operation, this probe may have potential for use in dissecting epiretinal membranes and other ophthalmic tissues without damaging adjacent retinal tissue.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Microsphere Scalpel Designmentioning

confidence: 99%

Characterization of novel microsphere chain fiber optic tips for potential use in ophthalmic laser surgery

Hutchens

Darafsheh²,

Fardad³

et al. 2012

J. Biomed. Opt.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our previous studies, such a structure was optimized for the best performance in contact with tissue. 25 We showed that the minimal spot sizes and combination with good coupling efficiency can be obtained in chains of 300 μm spheres with the index around n ¼ 1.71. The calculated irradiance profiles after three and five spheres show twofold spot size reduction compared to single sphere.…”

Section: Theoretical Modelingmentioning

confidence: 85%

“…22,23 Using similar ideas, recently, we proposed to develop a surgical system with an extremely compact focal spot and shallow depth of treatment, which can be used for segmenting pathologic epiretinal membranes without damaging the adjacent retina. [22][23][24][25][26][27] To this end, we developed the design of fiber-based microprobes capable of focusing light under contact conditions with tissue. 25 Specifically, we showed that a chain of microspheres with index n ¼ 1.71 is capable of focusing the beam at the tip of the end sphere with essentially zero focusing depth.…”

Section: Introductionmentioning

confidence: 99%

“…[22][23][24][25][26][27] To this end, we developed the design of fiber-based microprobes capable of focusing light under contact conditions with tissue. 25 Specifically, we showed that a chain of microspheres with index n ¼ 1.71 is capable of focusing the beam at the tip of the end sphere with essentially zero focusing depth. In addition, the device is capable of compact focusing of multimodal beams delivered by fibers or HWGs used in mid-IR optics.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Detachable microsphere scalpel tips for potential use in ophthalmic surgery with the erbium:YAG laser

Hutchens

Darafsheh

Fardad³

et al. 2014

J. Biomed. Opt

Self Cite

View full text Add to dashboard Cite

Abstract. Vitreoretinal surgery is performed using mechanical dissection that sometimes results in iatrogenic complications, including vitreous hemorrhage, retinal breaks, incomplete membrane delamination, retinal distortion, microscopic damage, etc. An ultraprecise laser probe would be an ideal tool for cutting away pathologic membranes; however, the depth of surgery should be precisely controlled to protect the sensitive underlying retina. The ultraprecise surgical microprobe formed by chains of dielectric spheres for use with the erbium: YAG laser source (λ ¼ 2940 nm), with extremely short optical penetration depth in tissue, was optimized. Numerical modeling demonstrated a potential advantage of five-sphere focusing chains of sapphire spheres with index n ¼ 1.71 for ablating the tissue with self-limited depth around 10 to 20 μm. Novel detachable microsphere scalpel tips formed by chains of 300 μm sapphire (or ruby) spheres were tested on ophthalmic tissues, ex vivo. Detachable scalpel tips could allow for reusability of expensive mid-infrared trunk fibers between procedures, and offer more surgical customization by interchanging various scalpel tip configurations. An innovative method for aiming beam integration into the microsphere scalpel to improve the illumination of the surgical site was also shown. Single Er:YAG pulses of 0.2 mJ and 75-μs duration produced ablation craters in cornea epithelium for one, three, and five sphere structures with the latter generating the smallest crater depth (10 μm) with the least amount of thermal damage depth (30 μm). Detachable microsphere laser scalpel tips may allow surgeons better precision and safety compared to mechanical scalpels when operating on delicate or sensitive areas like the retina. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

Concept of photonic hook scalpel generated by shaped fiber tip with asymmetric radiation

Minin

Liu²,

Tuchin

et al. 2020

Journal of Biophotonics

View full text Add to dashboard Cite

Structured light have made deep impacts on modern biotechnology and clinical practice, with numerous optical systems and lasers currently being used in medicine to treat disease. We demonstrate a new concept of fiber‐based optical hook scalpel. The subwavelength photonic hook is obtained in the vicinity of a shaped fiber tip with asymmetric radiation. A 1550 nm continuous‐wave source, commonly used for medical imaging, has been required. Photonic hook with a lateral feature size less than the half‐wavelength is achieved using a hemispherical shaped fiber tip with metallic mask. This breakthrough is carried out in ambient air by using a 4‐μm‐diameter fiber with a shaped tip. A good correlation is observed between the computed intensity distribution of photonic hook and the tip sizes. Photonic hook generated with a shaped fiber tip, easier to manipulate, shows far‐reaching benefits for potential applications such as ophthalmic laser surgery, super‐resolution microscopy, photolithography and material processing.

show abstract

Contact focusing multimodal microprobes for ultraprecise laser tissue surgery

Cited by 68 publications

References 32 publications

Characterization of novel microsphere chain fiber optic tips for potential use in ophthalmic laser surgery

Characterization of novel microsphere chain fiber optic tips for potential use in ophthalmic laser surgery

Detachable microsphere scalpel tips for potential use in ophthalmic surgery with the erbium:YAG laser

Concept of photonic hook scalpel generated by shaped fiber tip with asymmetric radiation

Contact Info

Product

Resources

About