Contact dermatitis to phenylephrine

Tosti, Andrea; Bardazzi, Federico; Ttosti, G; Colombati, S

doi:10.1111/j.1600-0536.1987.tb02673.x

Cited by 12 publications

(3 citation statements)

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“…Some single case reports have been found related to reactions due to eyedrops containing phenylephrine. In these, the concentrations and vehicles used for patch testing are diverse (2)(3)(4)(5). In no case was conjunctival challenge performed.…”

Section: Discussionmentioning

confidence: 99%

Reliability of diagnostic tests for contact allergy to mydriatic eyedrops

Villarreal

1998

Contact Dermatitis

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Adverse reactions due to the administration of mydriatic eyedrops are not uncommon. In Spain, the most commonly used are phenylephrine, tropicamide and cyclopentolate hydrochloride. In this study, 37 patients with adverse reactions to the administration of mydriatic eyedrops were investigated from January 1993 to June 1997. The aim was to assess the reliability of the diagnostic methods used, particularly the adequate concentration of allergens and the introduction of conjunctival challenge as a safe and accurate diagnostic tool in those patients who could not be diagnosed by other methods. Phenylephrine was the drug most frequently causing sensitization (93.5%) among the 31 allergic patients. Preservatives were the cause in only 1. Patch testing detected allergy in 68.5% of the subjects. 2 concentrations (1% and 10%) and vehicles (pet. and aq.) were used for phenylephrine. The most reliable was 10% aq. Reading at D4 was more useful than at D2. The sensitivity of the patch test was low (72.4%) and its negative predictive value (NPV) poor (42%). In 24% of patients, allergy to phenylephrine was detected only by conjunctival challenge test. This diagnostic method is safe and helpful and has not previously been used to diagnose adverse reactions due to mydriatic eyedrops.

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Section: Discussionmentioning

confidence: 99%

Reliability of diagnostic tests for contact allergy to mydriatic eyedrops

Villarreal

1998

Contact Dermatitis

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“…Since the first description by Mathias et al ( 4) in 1979 of allergic contact dermatitis from phenylephrine, further cases have been reported (5)(6)(7)(8)(9). It remains, however, a rare condition, despite extensive use by ophthalmologists.…”

Section: Discussionmentioning

confidence: 99%

Allergic contact blepharoconjunctivitis caused by phenylephrine eyedrops

1991

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“…[1,2] Even though reactions are frequently correlated to excipients [3][4][5] and to antibiotics, not rarely are described after instillation of mydriatic agent, in particular phenylephrine which is a direct sympathomimetic drug which interacts with alpha-adrenergic receptors. [6][7][8][9][10][11][12][13] Since a standardized panel of tests capable of identify the pathogenetic mechanism is not still available, Villareal, [14] as other authors, [15] have used a self-made patch tests panel with substances included in the eyedrops (either active principles or excipients) at different concentrations. In addition, other authors [16,17] have proposed intradermal tests only for the atropine, because its instillation induces general reactions, even if there are many evidences about local reactions at the level of eyelid and conjunctiva.…”

Section: Introductionmentioning

confidence: 99%