Contact dermatitis to henna used as a hair dye

Belhadjali, H.; Ghannouchi, N.; Amri, Charfeddine; Youssef, M.; Amri, M.

doi:10.1111/j.1600-0536.2007.01238.x

Cited by 20 publications

(7 citation statements)

References 4 publications

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“…The other reason for adding PPD to the natural henna is to speed up (shorten the time) of the tattooing process, while natural henna staining takes 4 to 12 hours, addition of PPD can reduce this time to an hour or two and also there will be a longer lasting effect as well. Thus, a new pattern of exposure to PPD has been recognized through henna art which increases the risk of developing adverse health effects related to PPD [15].…”

Section: Discussionmentioning

confidence: 99%

A study on contact dermatitis to hair dye and henna

Puri¹,

Puri²

2013

Our Dermatol Online

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P-Phenylenediamine is an oxidative chemical that is frequently used as a permanent hair-coloring agent. It is added to henna to increase the intensity and longevity of the tattoo and expedites its drying time. Henna itself is a greenish brown vegetable coloring made from the leaves of Lawsonia inermis and rarely causes allergic contact dermatitis. The addition of PPD causes the contact sensitization to black henna. Serious adverse skin reactions to permanent hair dyes and temporary black tattoos have been reported. As temporary tattoos have become fashionable among adolescents, the risk profile for p-phenylenediamine (PPD) sensitization of the population has changed simultaneously with an increasing use of hair dyes in this age group. With increased popularity of body art such as body piercing and tattooing, an increase in temporary henna tattoos has also occurred. Although the appeal of non-permanence exists for henna tattoos, dermatologists have begun to see numerous cases of allergic contact dermatitis linked with a certain type of henna. We selected 50 patients using hair dye and henna for our study. Patch testing was done in all the patients using Indian standard series of antigens. Regarding to the side effects to hair dye and henna and itching was the commonest symptom seen in 16% patients, erythematous scaly plaques were seen in 10% patients, vesicular reactions were seen in 6% patients, angioneurotic oedema and contact urticaria was seen in 4% patients each and anaphylaxis and keloidal reaction was seen in 2% patients each.

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Section: Discussionmentioning

confidence: 99%

A study on contact dermatitis to hair dye and henna

Puri¹,

Puri²

2013

Our Dermatol Online

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“…This natural dye is a safe substance with a very low allergenic response to the active ingredient Lawsonia (2‐hydroxy‐1, 4‐naphthoquinone). In the majority of cases, sensitization to henna is related to the addition of chemical coloring agents especially para‐phenylenediamine (PPD) (4,5). The latter is added to darken the dye and to improve its fixation.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, our case is unusual in that the sensitization was only to pure henna. Moreover, it is the first Tunisian pediatric case despite its wide use in our country (5).…”

Section: Discussionmentioning

confidence: 99%

Bullous Allergic Contact Dermatitis to Pure Henna in a 3‐Year‐Old Girl

Belhadjali

Akkari

Youssef

et al. 2011

Pediatric Dermatology

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“…26,27 Nowadays, henna is extensively used worldwide, owing to the popularity of body art and hair dye products. 28 Despite this extensive use, ACD caused by pure henna is extremely rare, and the allergic skin reactions reported have been associated with adulteration of henna with PPD, 25,26,[29][30][31] highlighting the fact that these products deserve special attention from regulatory agencies.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of “real‐life” mixtures: The case of henna‐based hair‐colouring products containing p‐phenylenediamine

et al. 2019

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Background: Allergic contact dermatitis caused by henna-based hair-colouring products has been associated with adulteration of henna with p-phenylenediamine (PPD).Objectives: To develop a testing approach based on in vitro techniques that address key events within the skin sensitization adverse outcome pathway in order to evaluate the allergenic potential of hair-colouring products. Methods:The following in vitro assays were used to test the sensitizing capacity of hair dye ingredients: the micro-direct peptide reactivity assay (mDPRA); the HaCaT keratinocyte-associated interleukin (IL)-18 assay; the U937 cell line activation test (U-SENS)/IL-8 levels; the blood monocyte-derived dendritic cell test; and genomic allergen rapid detection (GARD skin). Those techniques with better human concordance were selected to evaluate the allergenic potential of 10 hair-colouring products.Results: In contrast to the information on the label, chromatographic analyses identified PPD in all products. The main henna biomarker, lawsone, was not detected in one of the 10 products. Among the techniques evaluated by testing hair dye ingredients, the mDPRA, the IL-18 assay, GARD skin and the U-SENS correlated better with human classification (concordances of 91.7%-100%) and were superior to the animal testing (concordance of 78.5%). Thus, these assays were used to evaluate haircolouring products, which were classified as skin sensitizers by the use of different two-of-three approaches.Conclusions: Our findings highlight the toxicological consequences of, and risks associated with, the undisclosed use of PPD in henna-based "natural" "real-life" products. K E Y W O R D Sallergic contact dermatitis, alternative methods, cosmetics, hair dyes, mixtures, skin sensitization

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Contact dermatitis to henna used as a hair dye

Cited by 20 publications

References 4 publications

A study on contact dermatitis to hair dye and henna

A study on contact dermatitis to hair dye and henna

Bullous Allergic Contact Dermatitis to Pure Henna in a 3‐Year‐Old Girl

Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of “real‐life” mixtures: The case of henna‐based hair‐colouring products containing p‐phenylenediamine

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