Contact dermatitis to geraniol in a leg ulcer

Guerra, Pedro Jiménez; Aguilar, A. Robledo; Urbina, Francisco Zúñiga; Cristóbal, María Carmen; García-Pérez, A

doi:10.1111/j.1600-0536.1987.tb01473.x

Cited by 15 publications

(2 citation statements)

References 6 publications

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“…However, in other studies, the face was found to be most frequently involved (1, 20, 21, 25). The greater involvement of the legs may be attributed to the fact that among the population allergic to fragrances, many patients had vascular ulcers on the legs as a result of repeated exposure to topical drugs that frequently contained fragrance (18, 26–28). One of the most frequently used topical drugs for treating leg ulcers in Spain is Blastoestimulina ® (Almirall), which contains geraniol.…”

Section: Discussionmentioning

confidence: 94%

Fragrance contact allergy: a 4‐year retrospective study

et al. 2010

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Section: Discussionmentioning

confidence: 94%

Fragrance contact allergy: a 4‐year retrospective study

et al. 2010

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“…In a study on a patient who had reacted to an ointment used to treat a leg ulcer, positive reactions were observed to the fragrance of the ointment and to 2% geraniol [41] . A rating of 3 was accorded because other possible causes had not been completely excluded.…”

Section: (I) Tests Producing Reactionsmentioning

confidence: 99%

Is There Evidence that Geraniol Causes Allergic Contact Dermatitis?

Hostýnek¹,

Maibach²

2004

Exog Dermatol

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The fragrance material geraniol has been cited as a frequent cause of allergic contact dermatitis. A review of the literature shows that when the underlying clinical and experimental data are analyzed, a clear cause-effect relationship has infrequently or rarely been established. On the basis of the generally weak sensitizing potential of this substance coupled with its generally low exposure conditions, the prevalence of clinical cases would not be expected to be particularly high. This is not to say that geraniol is a frequent inducer of type IV allergy in members of the public. It remains to be seen, however, how often such allergy, once established, is responsible for any of the cases of allergic contact dermatitis commonly ascribed in the literature. Indeed, in some cases, patch-test conditions may not be optimal for differentiating between clinically relevant and irrelevant allergy to geraniol. Because of the numerous publications on geraniol-positive patch-test publications, a future effort to ascertain how many of these represent clinical intolerance is indicated. This will also permit determination of the NOEL (no observed effect level) in patch and use testing.

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Geraniol [MAK Value Documentation in German language, 2004]

2012

The MAK‐Collection for Occupational Health and Safety

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Contact dermatitis to geraniol in a leg ulcer

Cited by 15 publications

References 6 publications

Fragrance contact allergy: a 4‐year retrospective study

Fragrance contact allergy: a 4‐year retrospective study

Is There Evidence that Geraniol Causes Allergic Contact Dermatitis?

Geraniol [MAK Value Documentation in German language, 2004]

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