Contact dermatitis from prilocaine with cross‐sensitivity to pramocaine and bupivacaine

Contact allergy in chronic leg ulcers: results of a multicentre study carried out in 423 patients and proposal for an updated series of patch tests

“…It has been recommended to use EMLA cream for the mechanical debridement of leg ulcers. Three of our patients had a positive patch test with it, in addition to one case previously reported by García (42).…”

Allergic contact dermatitis from EMLA cream: concomitant sensitization to both local anesthetics lidocaine and prilocaine

“…In contrast to the former frequently used local anesthetics with an ester part (e. g. procaine and benzocaine), local anesthetics of the amide group are considered to be rare sensitizers [2, 3, 7, 8] and are rarely responsible for allergic reactions. Allergic contact dermatitis due to prilocaine has been reported in relation to EMLA cream [9, 5, 6]. To our best knowledge, this is the first report on simultaneous positive patch test reactions to both prilocaine and lidocaine after using EMLA cream.…”

“…To our best knowledge, this is the first report on simultaneous positive patch test reactions to both prilocaine and lidocaine after using EMLA cream. Some reports of lidocaine sensitivity [4] have described cross‐reactivity to prilocaine and other amide anesthetics, indicating the potential cross‐reactivity [9, 10]. For a complete allergological evaluation, testing with other constituents of EMLA cream (carboxypolymethylene, for example.)…”

Acute bullous irritant contact dermatitis caused by EMLA® cream

“…Patch testing gave a negative result, but no prick or intradermal tests were performed. Allergic contact dermatitis related to prilocaine (1–3) or to both components (4) has been previously reported, as well as contact urticaria caused by lidocaine after EMLA ® cream application (5). In those cases, patch testing was useful to find the culprit component.…”

“…They include itching, burning, pain, pallor or blanching, erythema, oedema, and purpura. Allergic contact dermatitis related to prilocaine has been reported (1–5). Rarely, cases of irritant contact dermatitis after EMLA ® cream application have been described (6–8).…”