Contact dermatitis from levobunolol and befunolol

Zucchelli, Valeria; Silvani, Simonetta; Vezzani, Claudia; Lorenzi, Sandra; Tosti, Antonella

doi:10.1111/j.1600-0536.1995.tb00464.x

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…There are different reports about cross‐sensitivity among β‐blockers in the past few years (5–8). Our case suggests the possibility of cross‐reaction between levobunolol and befunolol, supported by the positive patch test reaction to befunolol that had never previously been used.…”

Section: Commentsupporting

confidence: 54%

Allergic contact dermatitis due to levobunolol with cross‐sensitivity to befunolol

et al. 2006

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Section: Commentsupporting

confidence: 54%

Allergic contact dermatitis due to levobunolol with cross‐sensitivity to befunolol

et al. 2006

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“…Topical β blockers have been used as first line hypotensive therapy in the medical management of glaucoma for more than 30 years and an extensive local side effect profile has been documented which includes blurring, irritation, corneal anaesthesia, and punctate keratitis. 7 However, contact dermatitis is rarely associated with their use and in our literature search, using the Medline database, we found a total of 15 case reports of patients who developed contact allergy to topical timolol, [8][9][10][11][12] levobunolol, [11][12][13][14][15][16] or betaxolol therapy. 17 Furthermore, the continued tolerance of topical β blocker therapy by both groups (with their original β blocker in group 1 and with the identical β blocker, but in a preservative free form in group 2) excludes any causative role of this medication in the development of dermatitis in these patients.…”

Section: Discussionmentioning

confidence: 99%

Periorbital dermatitis as a side effect of topical dorzolamide

Delaney

Salmon²,

Mossa³

et al. 2002

British Journal of Ophthalmology

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“…Thirty‐six patients had at least one positive patch test with culprit eye drops, 4–10,12–14,16–18,20,22,23,25,27–31,33,34,36,38,41–43,45 5/7 only after skin stripping, 21,26,37 and two after a scratch patch test, 39 four patients out of six who performed ROAT were positive, 4,30,40,44 as well as three out of four who performed a use test 24,32 . All patients recovered on drug suspension.…”

Section: Ocular and Periocular Cutaneous Aes Secondary To Anti‐glauco...mentioning

confidence: 99%

“…Allergic contact dermatitis possibly induced by anti‐glaucoma eye drops was reported in 65 patients (Table 2). 4–45 The reported culprit active agents were mostly BB eye drops 4–49 . Patients may also react to an inactive agent: Jappe et al .…”

Section: Ocular and Periocular Cutaneous Aes Secondary To Anti‐glauco...mentioning

confidence: 99%

Dermatological adverse effects of anti‐glaucoma eye drops: a review

Patchinsky

Petitpain²,

Gillet

et al. 2022

Acad Dermatol Venereol

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Many patients are treated for glaucoma. Like other drugs, anti-glaucoma eye drops may induce dermatological adverse effects. We aim to review the dermatological adverse effects secondary to the active agents in anti-glaucoma eye drops through a literature review. In January 2020, we queried PubMed using the following MeSH terms: glaucoma/drug therapy or glaucoma, open angle/drug therapy cross-referenced with parasympathomimetics/adverse effects or adrenergic agonists/adverse effects or carbonic anhydrase inhibitors/adverse effects or prostaglandins F, synthetic/adverse effects or adrenergic beta antagonists/adverse effects or ophthalmic solutions/adverse effects. The initial search identified 1128 studies, of which 49 were excluded for being in a foreign language, 15 for not involving eye drops, 968 for not focusing on adverse dermatological effects, and 11 for insufficient documentation or redundancy. After adding 38 linked studies, we finally analyzed 123 studies. The ocular and periocular dermatological adverse effects of eye drops are contact dermatitis, hyperpigmentation, prostaglandin analog periorbitopathy, mucous membrane pemphigoid, eyelash depigmentation, skin hypertrichosis, and rare cases of melanoma and skin depigmentation. The reported distant dermatological adverse effects are psoriasis, excessive sweating, lichen planus, alopecia, toxic epidermal necrolysis, erythema multiforme, erythroderma, subacute cutaneous lupus erythematosus, nail pigmentation, and bullous pemphigoid. Most of the cutaneous adverse effects of anti-glaucoma eye drops are ocular and periocular and induced by prostaglandin analogs.Distant adverse effects are rare and sometimes questionable but should be kept in mind, especially mucous membrane pemphigoid, which could lead to blindness. The role of preservatives, such as benzalkonium chloride, should also be considered.

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Contact dermatitis from levobunolol and befunolol

Cited by 10 publications

References 10 publications

Allergic contact dermatitis due to levobunolol with cross‐sensitivity to befunolol

Allergic contact dermatitis due to levobunolol with cross‐sensitivity to befunolol

Periorbital dermatitis as a side effect of topical dorzolamide

Dermatological adverse effects of anti‐glaucoma eye drops: a review

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