Contact dermatitis due to topical cosmetic use of vitamin K

Veneziano, Leonardo Squinello Nogueira; Silvani, Simonetta; Voudouris, Stylianos; Tosti, Antonella

doi:10.1111/j.0105-1873.2005.00498h.x

Cited by 12 publications

(11 citation statements)

References 6 publications

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“…In the past, many cases of allergic contact dermatitis caused by topical vitamin K were reported in Italy, Spain, and France (11–15) (Table S1), which is why vitamin K was banned from use in cosmetic products in the EU in 2009 (16). The intention has been to use vitamin K 1 oxide (CAS no.…”

Section: Discussionmentioning

confidence: 99%

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

et al. 2017

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“…4). This observation may be useful in the development of future strategies for topical applications of high-dose methylprednisolone; for example, methylprednisolone could be combined with menadione derivatives or other oxidants with a lower risk for contact dermatitis (Camarasa & Barnadas, 1982;Dinis et al 1988;Veneziano et al, 2005) when the predisposition to candidiasis is high.…”

Section: Discussionmentioning

confidence: 99%

High-dose methylprednisolone influences the physiology and virulence ofCandida albicansambiguously and enhances the candidacidal activity of the polyene antibiotic amphotericin B and the superoxide-generating agent menadione

Gyetvai

Emri

Fekete

et al. 2007

FEMS Yeast Research

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Although exposure of Candida albicans cells to high-dose (4 mM) methylprednisolone stimulated microbial growth, germination rate in serum and phospholipase release, it also promoted the recognition of C. albicans cells by polymorphonuclear leukocytes. Pretreatment of C. albicans cells with methylprednisolone did not result in any increase in the pathogenicity of the fungus in intraperitoneal and intravenous mouse assays. Therefore, the virulence of C. albicans is unlikely to increase in patients treated with comparably high-dose methylprednisolone on skin and mucosal membranes. Methylprednisolone treatments also increased the production of conjugated dienes and thiobarbituric acid-reactive substances, and the menadione sensitivity of C. albicans cells, which can be explained by a significant decrease in the specific activities of several antioxidant enzymes. The combination of methylprednisolone with oxidants, e.g. in topical applications, may be of clinical importance when the predisposition to candidiasis is high. Methylprednisolone treatments negatively affected membrane fluidity and decreased the antifungal effects of both the polyene antibiotic nystatin and the ergosterol biosynthesis inhibitor lovastatin, and also enhanced the deleterious effects of the polyene antimycotic amphotericin B on C. albicans cells. These corticosteroid-polyene drug interactions should be considered in the treatment of C. albicans infections in patients with prolonged topical application of corticosteroids.

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“…Although ACD caused by cosmetic products containing the non‐oxidized form of vitamin K 1 have been widely reported, since it was banned in 2009 only 6 cases of ACD caused by products containing phytonadione epoxide have been observed, with contact allergy to this compound being shown in 4 cases. Although phytonadione oxide has been patch tested in 2 different concentrations (1% and 5% pet.)…”

Section: Discussionmentioning

confidence: 99%

“Crossed” allergic contact dermatitis caused by oxidized vitamin K₁ in a patient previously sensitized to non‐oxidized vitamin K₁

et al. 2018

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Contact dermatitis due to topical cosmetic use of vitamin K

Cited by 12 publications

References 6 publications

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

High-dose methylprednisolone influences the physiology and virulence ofCandida albicansambiguously and enhances the candidacidal activity of the polyene antibiotic amphotericin B and the superoxide-generating agent menadione

“Crossed” allergic contact dermatitis caused by oxidized vitamin K₁ in a patient previously sensitized to non‐oxidized vitamin K₁

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Contact dermatitis due to topical cosmetic use of vitamin K

Cited by 12 publications

References 6 publications

Erythema multiforme‐like reaction resulting from vitamin K1 oxide (phytomenadione epoxide)

Erythema multiforme‐like reaction resulting from vitamin K1 oxide (phytomenadione epoxide)

High-dose methylprednisolone influences the physiology and virulence ofCandida albicansambiguously and enhances the candidacidal activity of the polyene antibiotic amphotericin B and the superoxide-generating agent menadione

“Crossed” allergic contact dermatitis caused by oxidized vitamin K1 in a patient previously sensitized to non‐oxidized vitamin K1

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Product

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About

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

Erythema multiforme‐like reaction resulting from vitamin K₁ oxide (phytomenadione epoxide)

“Crossed” allergic contact dermatitis caused by oxidized vitamin K₁ in a patient previously sensitized to non‐oxidized vitamin K₁