1979
DOI: 10.1001/archderm.115.7.853
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Contact dermatitis due to nitroglycerin ointment

Abstract: Topical nitroglycerin ointment is among the most effective long-acting vasodilators currently available. We report two cases of contact dermatitis in which patch testing showed allergy to nitroglycerin-containing compounds. The severity of this dermatitis necessitated the discontinuation of topical nitroglycerin therapy in both patients. A potent corticosteroid cream applied once to previous nitroglycerin application sites prevented or minimized this dermatitis and enabled continuation of topical nitroglycerin… Show more

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Cited by 9 publications
(11 citation statements)
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“…Oral nitroglycerin did not provoke a cutaneous reaction either in our patient or in the cases reported by Hendricks et al [4]. The local concentration of antigen and the duration of exposure are among the factors contributing to the development of contact dermatitis.…”
Section: Discussionsupporting
confidence: 56%
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“…Oral nitroglycerin did not provoke a cutaneous reaction either in our patient or in the cases reported by Hendricks et al [4]. The local concentration of antigen and the duration of exposure are among the factors contributing to the development of contact dermatitis.…”
Section: Discussionsupporting
confidence: 56%
“…The local concentration of antigen and the duration of exposure are among the factors contributing to the development of contact dermatitis. Thus, the plasma level of oral nitroglycerin may be sufficient to sensitize a patient as reported by Hendricks et al [4], and Camarasa and Perez [5], but appears in sufficient to elicit a cutaneous reaction in a nitroglycerin-patch-test-positive patient.…”
Section: Discussionmentioning
confidence: 78%
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“…The other patient developed a generalized eruption 6 months after beginning nitroglycerin therapy. 2 others demonstrated contact dermatitis from the ointment and patch testing revealed a positive reaction to the nitrate (15). The severity of reaction required cessation of topical treatment in both.…”
Section: Adverse Reactionsmentioning
confidence: 99%
“…After this became available, there were several reports of allergic reactions. The most frequent presentation was allergic contact dermatitis at the site of application (Hendricks & Dec 1979;Sausker & Frederick 1978;Zugerman et al 1979), but angioedema with swelling of the oral and conjunctival mucosa has also been described (Chandraratna & O'Dell 1979).…”
Section: Nitroglycerin (Glyceryl Trinitrate)mentioning
confidence: 99%