Contact Dermatitis Due to Codeine

Occupational allergic contact dermatitis caused by morphine

“…Cutaneous sensitization resulting from topical application or systemic administration of opium and its derivatives has been reported as early as 1882, according to Touraine's extensive review (1). The first half of the 20th century saw the publication of a certain number of cases of occupational dermatitis caused by opioids (2–4). Additional reports have since followed (5–8).…”

“…1). Not surprisingly, many patients sensitized to one compound exhibit cross‐reaction to one or more of the other phenanthrene opioids (2, 3, 5–13). Among 8 nurses sensitized to heroin, 6 also reacted to morphine and 4 to codeine (8).…”

“…Many patients who had positive patch test reactions to opioids presented with a drug eruption and were therefore sensitized through systemic administration (9–17). However, systemic administration after sensitization by topical exposure can also trigger systemic allergic dermatitis with generalized eruptions (2, 3). Given that such patients may need opioid analgesics after trauma as well as dental or other surgical procedures, it is important to test them with different drugs in order to determine which one they can safely use.…”

Occupational contact dermatitis caused by opioids: A case series

“…Cutaneous sensitization to topical opioids was first described in 1882, according to Touraine's extensive review . Subsequently, cases of occupational allergic contact dermatitis (ACD) have been reported in morphine‐industry workers, doctors, nurses, and pharmaceutical workers . In 2012, Wootton et al were the first to describe occupational ACD caused by oxycodone, in three pharmaceutical workers .…”

“…6 Subsequently, cases of occupational allergic contact dermatitis (ACD) have been reported in morphine-industry workers, doctors, nurses, and pharmaceutical workers. [6][7][8][9][10][11] In 2012, Wootton et al were the first to describe occupational ACD caused by oxycodone, in three pharmaceutical workers. 12 Recently Dekeyser reported ACD caused by oripavine (tested at 5% pet., ethanol and aq.)…”