Contact Dermatitis Caused by Sesquiterpene Lactones

Spettoli, Elisa; Silvani, Simonetta; Lucente, Pasquale; Guerra, Liliana; Vincenzi, Colombina

doi:10.1097/01206501-199803000-00011

Cited by 6 publications

(7 citation statements)

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“…Numerous cases of contact dermatitis caused by arnica have been reported. 4 Arnica tincture has been reported to cause bullous dermatitis after treatment of a knee injury and mild skin trauma. Both cases were confirmed by patch testing with 0.5% arnica extract in ether.…”

Section: Arnica Flowersmentioning

confidence: 99%

Contact dermatitis to botanical extracts

Kiken

Cohen

2002

American Journal of Contact Dermatitis

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A review of the literature of reported cases of contact dermatitis to a variety of natural herbal extracts is Presented. Natural extracts are commonly used ingredients in many cosmetic preparations and homeopathic remedies. Although the term natural botanical extracts inherently purports to have beneficial and benign properties, these extracts can cause adverse reactions in individuals. As such, dermatologists should be cognizant of these agents as possible sources of allergenicity in patients presenting with contact dermatitis.

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Section: Arnica Flowersmentioning

confidence: 99%

Contact dermatitis to botanical extracts

Kiken

Cohen

2002

American Journal of Contact Dermatitis

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“…The majority of these were ascribed to the use of the – often inexpediently undiluted – SL‐containing tincture of arnica (17). Among 3 more recent reports on positive patch test reactions to tincture of arnica, only 1 was due to sensitization from the tincture; the others were ascribed to cross‐reactivity which may occur with sunflower, chrysanthemum and other Compositae species (4, 19–22). A 0.5% petrolatum (pet.)…”

Section: Arnica Montana L(arnica; Inci Name Arnica Montana)mentioning

confidence: 99%

Contact sensitization from Compositae‐containing herbal remedies and cosmetics

Paulsen

2002

Contact Dermatitis

140

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The Compositae (Asteraceae) family of plants is currently an important cause of allergic plant contact dermatitis in Europe. The family comprises some of the oldest and most valued medicinal plants, and the increasing popularity of herbal medicine and cosmetics may theoretically result in a growing number of Compositae sensitizations from these sources. According to the literature at least 15 species, including among others arnica (Arnica montana), German and Roman chamomile (Chamomilla recutita and Chamaemelum nobile), marigold (Calendula officinalis), Echinacea and elecampane (Inula helenium), have been suspected of sensitization or elicitation of Compositae dermatitis. Epidemiological data are available for 2 species only, arnica and German chamomile, the rest of the evidence being anecdotal. Based on this, sensitization seems to occur relatively frequently with a few species such as arnica and elecampane, and occurs rarely with the majority, especially the widely used German chamomile. Sesquiterpene lactones are the most important allergens, but there are a few cases of sensitization from a coumarin, a sesquiterpene alcohol and a thiophene. The risk of elicitation of dermatitis by using Compositae-containing products in Compositae-sensitive individuals is by-and-large unknown.

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“…A synthetic pyrethroid, permethrin is not considered an allergen. In contrast to naturally‐ occurring pyrethrum ingredients, it has no relationship to the sesquiterpene lactones or to trans‐chrysanthemic acid and derivatives of trans‐pyrethric acid [20].…”

Section: Discussionmentioning

confidence: 99%

“…Considering the toxicological concerns, it is surprising that lindane is still the most frequently prescribed scabicidal in Germany. The substance has been taken from the British market and, according to an EU directive, can be marketed in Germany only until 2007 [7, 20, 21]. With 5% permethrin cream we now have a less toxic and, with correct application, at least equally efficacious option available.…”

Section: Discussionmentioning

confidence: 99%