Contact dermatitis caused by homemade “slime”: Report of two cases with chemical analysis

Tehrany, Yassaman Alipour; Quenan, Sandrine; Bugey, Aurélie; Piletta, Pierre

doi:10.1111/cod.13230

Cited by 10 publications

(10 citation statements)

References 3 publications

(3 reference statements)

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“…Slime dermatitis has been reported in only 12 children previously (Supporting Information Table S1). Of these, 10 were female, as were all of our patients. Patch testing was performed in six cases .…”

Section: Discussionmentioning

confidence: 76%

“… Of these, 10 were female, as were all of our patients. Patch testing was performed in six cases . Similarly to our patients, five children showed positive reactions to MCI/MI and MI, and one showed a positive reaction to paraben mix.…”

Section: Discussionmentioning

confidence: 76%

“…Similarly to our patients, five children showed positive reactions to MCI/MI and MI, and one showed a positive reaction to paraben mix. The source of isothiazolinones was the glue or liquid detergent used for the preparation of slime . Similarly, the sources of MCI/MI and MI in our patients were dishwashing liquid, glue, and liquid soap, which were added to the homemade slime mixture.…”

Section: Discussionmentioning

confidence: 87%

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“Slime”: A trending cause of isothiazolinone contact allergy in children

2019

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K E Y W O R D S : case report, contact allergy, methylchloroisothiazolinone/methylisothiazolinone, methylisothiazolinone, paediatric, slime dermatitis Methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) (eg, Kathon CG), and MI are widely available preservatives that are mainly used in cosmetic and household products. Following a worldwide increase in contact allergy to MCI/MI and MI, 1 regulatory measures have been implemented. Although a decrease in contact sensitization has been reported, MCI/MI and MI are still frequent causes of contact dermatitis, and unexpected sources of exposure may be encountered in clinical practice. 2 Herein, we report three children with allergic contact dermatitis caused by MCI/MI and/or MI following exposure to a homemade play material called "slime." CASE REPORTSA 9-year-old girl presented with hand dermatitis of 3 months' duration. Dermatological examination showed papules and vesicles involving the lateral aspects of the fingers and periunguium ( Figure 1A). She had no personal or family history of atopy. Previous treatment attempts with topical corticosteroids led to temporary improvement, but the lesions had recurred. A 12-year-old girl was referred to our clinic with hand dermatitis of 5 months' duration. Physical examination showed erythematous, scaly plaques on both palms ( Figure 2A).The patient's medical history was insignificant. Treatment with topical corticosteroids was of no benefit. A 10-year-old, otherwise healthy girl presented with hand eczema that had developed after contact with homemade slime. Physical examination showed mild erythema with desquamation on the sides of the fingers ( Figure 3A). The patient claimed that the initial vesicular eruption has resolved shortly after she had stopped coming into contact with slime.The patients were patch tested with the European baseline series by the use of IQ Ultra Chambers obtained from Chemotechnique Diagnostics (Vellinge, Sweden). Reading of test results was performed on day (D) 2 and D3, according to ESCD guidelines. 3 The patch test results were as follows: In case 1, there was a + reaction to MCI/MI 0.02% aq. on D2, and there was a ++ reaction to MCI/MI 0.02% aq. on D3 ( Figure 1B). In case 2, there were + reactions to MCI/MI 0.02% aq. and to MI 0.2% aq. on D2, and ++ reactions to MCI/MI 0.02% aq. and to MI 0.2% aq. on D3 ( Figure 2B). In case 3, there was a ?+ reaction to MCI/MI 0.02% aq. on D2, and there was a + reaction to MCI/MI 0.02% aq. on D3 ( Figure 3B).A detailed repeat history showed contact with a homemade play material called "slime" in all three patients before the onset of symptoms.The cosmetic and household products added to the slime mixture were brought in by each patient, and detailed inspection of the labels and material safety data sheets confirmed the presence of MCI and MI in the following products: case 1-dishwashing liquid ( Figure S1A); case 2-Polyvinyl acetate glue (Figure S1B); and case 3-liquid soap ( Figure S1C). DISCUSSIONAlthough MCI/MI contact sensitization and MI contact s...

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 87%

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“Slime”: A trending cause of isothiazolinone contact allergy in children

2019

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“…Children have repeatedly been found to become sensitised to isothiazolinones (or occasionally other preservatives) when producing "home-made" playdough ("slime") or using commercial products containing these preservatives [118][119][120][121][122]. Misuse of a glitter glue sold on a market as "artistic material" as carnival make-up had resulted in papular face ACD [123].…”

Section: Preservativesmentioning

confidence: 99%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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“…However, slime is now also being marketed in commercial multicomponent kits containing a slime base with additives such as fragrances and dyes. Numerous cases of irritant and allergic contact dermatitis to slime have been reported, with isothiazolinones in household slime ingredients such as glue or detergent commonly identified as a likely sensitizer 1 . However, the ingredients in store-bought toys are not frequently listed on product labeling.…”

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confidence: 99%

Isothiazolinones Common in Children's Toy Slime

et al. 2021

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Background: Contact dermatitis to homemade slime has been frequently reported, with isothiazolinones as a likely sensitizer. Little is known on the presence of these preservatives in commercial, store-bought slime products.Objectives: The aims of the study were to review the literature on "slime dermatitis" and to assess for the presence of isothiazolinones in commercially available slime products and homemade slime components.Methods: An experimental, colorimetric spot test was used to verify the presence of isothiazolinones in 38 slime products of the 16 best-selling commercial slime kits, 1 finished homemade slime, and 4 common components of homemade slime. High-performance liquid chromatography with UV detection was performed on 8 commercial slime products.Results: According to the spot test, 27 (71%) of the 38 commercial slime products contained isothiazolinones. High-performance liquid chromatography with UV detection analyses indicated, however, that false-positives and false-negatives readily occur: isothiazolinone content was correctly identified in only 4 (50%) of the 8 samples.Conclusions: This study is the first to demonstrate the presence of isothiazolinones in commercial slime toys. Although the colorimetric spot test may have some utility as a screening assay, it is far from specific and likely not sensitive enough to reliably identify methylisothiazolinone.

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Contact dermatitis caused by homemade “slime”: Report of two cases with chemical analysis

Cited by 10 publications

References 3 publications

“Slime”: A trending cause of isothiazolinone contact allergy in children

“Slime”: A trending cause of isothiazolinone contact allergy in children

Contact Allergy—Emerging Allergens and Public Health Impact

Isothiazolinones Common in Children's Toy Slime

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