Contact Allergy to Limonene from a Home-Made Cosmetic

Abstract

Contact allergy to fragrances is very common. It is the second sensitizer in contact allergic dermatitis, after nickel sulphate. The fragrance mix and Balsam of Peru affects about 50-80% of patients affected by fragrance allergy, but the study of recent literature highlights new markers implicated in the pathogenesis of this dermatitis. We report an unusual case of contact allergy to Iimonene in a young woman after daily Use of a self-made cosmetic product containing lemon juice and peel (rich in limonene), with a positive reaction to Balsam of Peru to patch test and a positive reaction to patch by patch performed with her cosmetic and lemon peel. This simultaneous sensitization has been previously described in literature.

Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies

“…C. limon essential oil contains photosensitizing compounds belonging to the linear furanocoumarin group. The lemon pericarp contains: bergapten, phellopterin, 5-and 8-geranoxypsoralen, and the essential oil contains: bergapten, imperatorin, isopimpinellin, xanthotoxin, oxypeucedanin and psoralen [21,82].…”

Response of Orchid Cut Flowers as Affected by Floral Preservatives on the Postharvest Quality

“…It is also an important constituent of various fragrances and perfumes (Ciriminna et al, 2014). In agriculture it is also used as potential ecological insecticide and sometimes as an ingredient of poultry feed (Tammaro et al, 2012). Limonene has also shown the potential of being an eco-friendly alternative to toxic fossil fuel based solvents (Ciriminna et al, 2014).…”

Gas Chromatography-Mass Spectrometry (GC-MS) Metabolite Profiling of Citrus limon (L.) Osbeck Juice Extract Evaluated for its Antimicrobial Activity Against Streptococcus mutans

“…Most frequently, gas chromatography-mass spectrometry (GC-MS) is employed for the investigation of plant metabolites [24][25][26][27][28]. The gold standard for elucidating phytochemical profiles of plant extracts is GC-MS, due to its great selectivity and sensitivity.…”