Contact Allergy to Cannabis and Related Essential Oils

Azim, Sara Abdel; Yim, Kaitlyn; Higgins, Shauna; Wurzer, Josh; Adler, Brandon

doi:10.1097/der.0000000000000869

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…However, terpenes (particularly in essential oils and fragrances) have been suggested to contribute to contact allergy and dermatitis although mechanistic insights are severely lacking [ 36 , 37 , 38 ]. Certain physical and chemical features of terpenes may contribute to their allergenicity.…”

Section: Discussionmentioning

confidence: 99%

Epicutaneous Sensitization to the Phytocannabinoid β-Caryophyllene Induces Pruritic Inflammation

Inan,

Ward,

Baltazar

et al. 2023

IJMS

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In recent years, there has been increased accessibility to cannabis for recreational and medicinal use. Incidentally, there has been an increase in reports describing allergic reactions to cannabis including exacerbation of underlying asthma. Recently, multiple protein allergens were discovered in cannabis, yet these fail to explain allergic sensitization in many patients, particularly urticaria and angioedema. Cannabis has a rich chemical profile including cannabinoids and terpenes that possess immunomodulatory potential. We examined whether major cannabinoids of cannabis such as cannabidiol (CBD) and the bicyclic sesquiterpene beta-caryophyllene (β-CP) act as contact sensitizers. The repeated topical application of mice skin with β-CP at 10 mg/mL (50 µL) induced an itch response and dermatitis at 2 weeks in mice, which were sustained for the period of study. Histopathological analysis of skin tissues revealed significant edema and desquamation for β-CP at 10 mg/mL. For CBD and β-CP, we observed a dose-dependent increase in epidermal thickening with profound thickening observed for β-CP at 10 mg/mL. Significant trafficking of CD11b cells was observed in various compartments of the skin in response to treatment with β-CP in a concentration-dependent manner. Mast cell trafficking was restricted to β-CP (10 mg/mL). Mouse proteome profiler cytokine/chemokine array revealed upregulation of complement C5/5a (anaphylatoxin), soluble intracellular adhesion molecule-1 (sICAM-1) and IL-1 receptor antagonist (IL-1RA) in animals dosed with β-CP (10 mg/mL). Moreover, we observed a dose-dependent increase in serum IgE in animals dosed with β-CP. Treatment with β-CP (10 mg/mL) significantly reduced filaggrin expression, an indicator of barrier disruption. In contrast, treatment with CBD at all concentrations failed to evoke scratching and dermatitis in mice and did not result in increased serum IgE. Further, skin tissues were devoid of any remarkable features, although at 10 mg/mL CBD we did observe the accumulation of dermal CD11b cells in skin tissue sections. We also observed increased filaggrin staining in mice repeatedly dosed with CBD (10 mg/mL). Collectively, our studies indicate that repeated exposure to high concentrations of β-CP can induce dermatitis-like pathological outcomes in mice.

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Section: Discussionmentioning

confidence: 99%

Epicutaneous Sensitization to the Phytocannabinoid β-Caryophyllene Induces Pruritic Inflammation

Inan,

Ward,

Baltazar

et al. 2023

IJMS

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“…To the best of our knowledge, one other case of ACD from C. sativa seed oil has just recently been published 7 . With increasing patient interest in the use of hemp seed oil, further studies are required to clarify its content of allergens.…”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis from Cannabis sativa (hemp) seed oil

et al. 2022

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“…Several reports of type I sensitization to cannabis plants (contact urticaria, anaphylaxis) have been published. [1][2][3][4] Only a few individual case reports exist to date about contact allergic reactions to hemp seed oil with CBD 5,6 : For example, a young female patient developed eczema in the areas where she applied C. sativa seed oil. A type IV sensitization was confirmed by patch test and repetitive open application test.…”

Section: Case Reportmentioning

confidence: 99%

“…[1][2][3] In contrast, there are only very few descriptions of IgE-mediated hypersensitivities. [4][5][6] We here report an 8-year-old girl who complained about recurrent shortness of breath and an itchy nose when brushing her teeth with different brands of toothpaste. She had no known allergies and was not suffering from atopic dermatitis, allergic rhinoconjunctivitis or bronchial asthma.…”

mentioning

confidence: 95%

Occupational allergic contact dermatitis to marijuana

Heyne,

Steininger,

Bauer

2024

Contact Dermatitis

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Allergies to toothpaste mainly encompass type 4 reactions, with aromas or flavourings as potential allergens. [1][2][3] In contrast, there are only very few descriptions of IgE-mediated hypersensitivities. [4][5][6] We here report an 8-year-old girl who complained about recurrent shortness of breath and an itchy nose when brushing her teeth with different brands of toothpaste. She had no known allergies and was not suffering from atopic dermatitis, allergic rhinoconjunctivitis or bronchial asthma. Skin prick tests (SPT) as well as open patch tests (OPT, evaluated after 20 min) showed positive results with five toothpastes reported to elicit dyspnea, but not three formerly well tolerated products. Tests with

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Contact Allergy to Cannabis and Related Essential Oils

Cited by 7 publications

References 6 publications

Epicutaneous Sensitization to the Phytocannabinoid β-Caryophyllene Induces Pruritic Inflammation

Epicutaneous Sensitization to the Phytocannabinoid β-Caryophyllene Induces Pruritic Inflammation

Allergic contact dermatitis from Cannabis sativa (hemp) seed oil

Occupational allergic contact dermatitis to marijuana

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