Contact allergy to benzyl salicylate

Fernández‐Canga, Paula; Ruíz‐González, Inmaculada; Varas‐Meis, Eduardo; Valladares-Narganes, Luis Miguel; Rodríguez-Prieto, Manuel Ángel

doi:10.1111/cod.12707

Cited by 5 publications

(6 citation statements)

References 4 publications

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“…The International Fragrance Association (IFRA) Standard limits the range from 0.5% benzyl salicylate in lip products to 12.8% in oral care products. 8 Benzyl salicylate has been considered to be an uncommon aller- Clinically, sensitization to benzyl salicylate has been typically described in relation to two scenarios: eyelid allergic contact dermatitis from hair products 11,12 and pigmented allergic contact dermatitis. 13,14 In addition, long-term daily application of hair sunscreen spray with benzyl salicylate to the hair part line of the scalp has been published to likely perpetuate the lesions of lichen planopilaris in a woman.…”

Section: Discussionmentioning

confidence: 99%

Sensitization to benzyl salicylate and other allergens in patients with frontal fibrosing alopecia

et al. 2021

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Background: Contact sensitization is frequent among patients with frontal fibrosing alopecia (FFA) (52%-76%).Objective: To evaluate the frequency of sensitization/photosensitization in an FFA population.Methods: A population of FFA patients were patch tested (Spanish Contact Dermatitis Research Group [GEIDAC] baseline; cosmetic and fragrance series), and photopatch tested (sunscreen series).Results: Thirty-six patients (mean age: 64.6 years; 35/36: women) were studied. A history of dermatitis was recorded in 69.4% (frequently involving the face). Overall, 80.5% patients showed positive patch-test reactions. The most frequently positive allergens were nickel sulfate (25%), benzyl salicylate (22%), gallates (16.6%), propolis (16.6%), and limonene hydroperoxides (13.8%). Benzyl salicylate was likely relevant to the dermatitis (labeled on personal care products and most patients reporting clinical improvement with allergen avoidance). Patch tests with sunscreens showed positive reactions to 11 materials (five patients). Photopatch tests were positive in one case. Conclusion:We speculate a possible relationship between sensitization to benzyl salicylate and FFA. Hypothetically, the most likely explanation is that sensitization to benzyl salicylate involving FFA patients is a consequence of increased exposure to it.It is unclear whether allergen avoidance may impact the prognosis of alopecia. However, it seems to significantly improve the patients´quality of life by lessening dermatitis and pruritus. K E Y W O R D S allergic contact dermatitis, benzyl salicylate (CAS no. 118-58-1), fragrance, frontal fibrosing alopecia, gallates, patch tests, photopatch tests, propolis, scarring alopecia, sunscreen 1 | INTRODUCTION Frontal fibrosing alopecia (FFA) is an inflammatory type of alopecia in which lichenoid lymphocytic infiltrates lead to perifollicular fibrosis and irreversible loss of follicles. It mainly concerns the frontal, The authors do not have any conflicts of interest to declare.

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Section: Discussionmentioning

confidence: 99%

Sensitization to benzyl salicylate and other allergens in patients with frontal fibrosing alopecia

et al. 2021

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“…2,3 Facial allergic contact dermatitis with eyelid involvement is apparently very rare, and, in the literature reviewed, a single case was found, associated with the application of various products to parts of the body other than the scalp. 5 We describe the first case, to the best of our knowledge, of facial allergic contact dermatitis with eyelid involvement caused by benzyl salicylate included in hair products. We…”

Section: Discussionmentioning

confidence: 94%

Allergic contact dermatitis caused by benzyl salicylate in hair products

et al. 2018

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“…If a weak (fragrance) contact allergen is found in many products, the patient may need to sort out many of his cosmetic products, as illustrated by a 60-year-old Spanish patient, who suffered from periorbital eczema due to sensitisation to benzyl salicylate, and identified 5 of her own products needing to be discarded [ 75 ]. L -Carvone is a known contact allergen and has been found (as constituent of mint flavour) in 64 of 66 Swedish brand toothpastes examined; in 10 of these the concentration exceeded 0.1% [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

Contact Allergy: A Review of Current Problems from a Clinical Perspective

Uter

Werfel

White

et al. 2018

IJERPH

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Contact allergy is common, affecting 27% of the general population in Europe. Original publications, including case reports, published since 2016 (inclusive) were identified with the aim of collating a full review of current problems in the field. To this end, a literature search employing methods of systematic reviewing was performed in the Medline® and Web of Science™ databases on 28 January 2018, using the search terms (“contact sensitization” or “contact allergy”). Of 446 non-duplicate publications identified by above search, 147 were excluded based on scrutiny of title, abstract and key words. Of the remaining 299 examined in full text, 291 were deemed appropriate for inclusion, and main findings were summarised in topic sections. In conclusion, diverse sources of exposures to chemicals of widely-differing types and structures, continue to induce sensitisation in man and may result in allergic contact dermatitis. Many of the chemicals are “evergreen” but others are “newcomers”. Vigilance and proper investigation (patch testing) are required to detect and inform of the presence of these haptens to which our populations remain exposed.

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Contact allergy to benzyl salicylate

Cited by 5 publications

References 4 publications

Sensitization to benzyl salicylate and other allergens in patients with frontal fibrosing alopecia

Sensitization to benzyl salicylate and other allergens in patients with frontal fibrosing alopecia

Allergic contact dermatitis caused by benzyl salicylate in hair products

Contact Allergy: A Review of Current Problems from a Clinical Perspective

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