Contact allergy in atopic dermatitis: A prospective study on prevalence, incriminated allergens and clinical insights

Abstract

BackgroundThe relationship between atopic dermatitis (AD) and allergic contact dermatitis (ACD) is a matter of debate.ObjectivesThe purpose of our study is to assess the frequency of ACD in patients with AD, the incriminated allergens and the potential risk factors.MethodsThis is a prospective study, including cases of AD diagnosed based on Hanifin and Rajka's criteria. All patients were patch tested to the European baseline series and corticosteroid series.ResultsNinety‐three patients were included. Fifty‐six patients (60.2%) had positive patch test results of which 71.4% were relevant. The most frequent allergens were: textile dye mix (24.7%), nickel (20.4%), cobalt (12.9%), isothiazolinone (8.6%), quanterium 15 (4.3%) and balsam of Peru (4.3%). Chromium, fragrance mix I, fragrance mix II and PTBP were positive in three cases (3.2%). Two cases of allergy to corticoids were identified. Facial involvement and duration of AD were significantly associated with contact sensitization (p = 0.04 and p = 0.005, respectively). Avoidance of relevant allergens resulted in a statistically significant decrease in SCORAD (p < 0.001).ConclusionsACD remains an important co‐morbidity of AD. We observed a high frequency of ACD to textile dyes, isothiazolinones and fragrances. Avoidance of relevant allergens has resulted in an improvement of patients' skin symptoms.