Consumption of Whey in Combination with Dairy Medium‐Chain Fatty Acids (MCFAs) may Reduce Lipid Storage due to Urinary Loss of Tricarboxylic Acid Cycle Intermediates and Increased Rates of MCFAs Oxidation

Amer, Bashar; Clausen, Morten Rahr; Bertram, Hanne Christine; Bohl, Mette; Nebel, Caroline; Zheng, Hong; Skov, Thomas; Larsen, Mette Krogh; Gregersen, Søren; Hermansen, Kjeld; Dalsgaard, Trine Kastrup

doi:10.1002/mnfr.201601048

Cited by 13 publications

(8 citation statements)

References 57 publications

(80 reference statements)

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“…While randomized, clinical trials have many advantages over cross-sectional studies (e.g., determination of causality), they depend on a properly controlled study design. Accordingly, a significant limitation in most of the clinical trials to date is that the study design did not control for the dietary intake of participants [46,47,48,49,50,56,57,58,60,61,62]. The heterogeneity of diets between subjects severely restricts the reliability of these data, particularly when the intervention depended on small dietary changes (e.g., approximately 1.6 g/d difference in FA intake [46,47,58,62]).…”

Section: Epidemiological and Clinical Studies: The Effects Of Dairmentioning

confidence: 99%

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

2019

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Lifestyle is a key modifiable risk factor involved in the manifestation of metabolic syndrome and, in particular, diet plays a pivotal role in its prevention and development. Current dietary guidelines discourage the consumption of saturated fat and dietary sources rich in saturated fat, such as dairy products, despite data suggesting that full-fat dairy consumption is protective against metabolic syndrome. This narrative review assessed the recent epidemiological and clinical research that examined the consumption of dairy-derived saturated fatty acids (SFA) on metabolic syndrome risk. In addition, this review evaluated studies of individual SFA to gain insight into the potential mechanisms at play with intake of a diet enriched with these dairy-derived fatty acids. This work underscores that SFA are a heterogenous class of fatty acids that can differ considerably in their biological activity within the body depending on their length and specific chemical structure. In summary, previous work on the impact of dairy-derived SFA consumption on disease risk suggests that there is currently insufficient evidence to support current dietary guidelines which consolidate all dietary SFA into a single group of nutrients whose consumption should be reduced, regardless of dietary source, food matrix, and composition.

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Section: Epidemiological and Clinical Studies: The Effects Of Dairmentioning

confidence: 99%

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

2019

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“…Up-and down-regulation of carbohydrates and organic acids were possibly related to the dynamic energy changes of S. paramamosain in response to low salinity. Lipid and amino acid metabolism were also vital pathways for energy production (Amer et al, 2017). Osmotic stress could induce physiological responses such as increased dissolved oxygen consumption (Spanopoulos-Hernańdez et al, 2005) and ammonia excretion (Chen and Lin, 1994;Silvia et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Multiple low salinity stress modes provided novel insight into the metabolic response of Scylla paramamosain adapting to inland saline-alkaline water

Niu

Gao²,

Qin³

et al. 2022

Front. Mar. Sci.

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Scylla paramamosain is a high-quality cultivar for saline-alkaline water aquaculture as a euryhaline crustacean species. However, salinity impacts the respiratory metabolism, growth, and survival of marine crustaceans. The metabolic response of crabs adapting to multiple low salinity environments has not been thoroughly studied yet, especially in inland saline-alkaline water. In this study, we analyzed metabolites in the gill and hemolymph of crabs cultured in three different low salinity environments. The results showed that membrane composition (lipids and lipid molecules) and free amino acids played an essential role in the osmoregulation of crabs, and the energy consumption accompanied as well. Meanwhile, S. paramamosain relied on ion transport and energy metabolism under acute/short-term low salinity conditions for osmoregulation. In contrast, amino acids and energy metabolism occupied a leading position in long-term low salinity. Furthermore, taurine and hypotaurine play a vital role in crabs adapting to inland saline-alkaline water. This is the first study to identify the crucial metabolites and key pathways as biomarkers to differentiate the metabolic mechanisms of S. paramamosain under multiple low salinity stress modes based on GC-MS technology, which provided novel insight into the metabolic response of S. paramamosain adapting to inland low salinity saline-alkaline water, and provided theoretical guidance for the aquaculture of S. paramamosain in the inland saline-alkaline water.

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“…Azelaic acid, a saturated 9-carbon atom dicarboxylic acid, in urine is usually used to indicate the fatty acid oxidation [61,62]. It has been generally thought that azelaic acid is produced by ω -oxidation of long-chain unsaturated fatty acids followed by their β -oxidation [63].…”

Section: Discussionmentioning

confidence: 99%

Effect of Fermented Cottonseed Meal on the Lipid-Related Indices and Serum Metabolic Profiles in Broiler Chickens

Niu

Zhang

Wei

et al. 2019

Animals

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Simple SummaryExcessive fat deposition in broiler chickens is detrimental for both producers and consumers. Fermented cottonseed meal (FCSM) was proposed as a potential method to relieve fat deposition in broilers’ rearing, while the physiological and metabolic mechanisms behind that still remain unclear. This study showed that both abdominal fat content and subcutaneous fat thickness significantly decreased in response to dietary FCSM supplementation at the age of 21 d, and altered the lipid-related metabolites index in serum, liver, and abdominal fat. Moreover, serum metabolic pathways were clustered into organic acid metabolism, fatty acid metabolism, and amino acid metabolism.AbstractThis study aimed to investigate the changes of lipid-related gene and serum metabolites in broiler chickens fed with fermented cottonseed meal (FCSM) diet, through quantitative real-time PCR and metabolomics analysis. Totally, 180 1-day-old Cobb broilers were randomly assigned to two groups with six replicates of 15 birds in each. The two diets consisted of a control diet supplemented with 0% FCSM (CON group) and an experimental diet with 6% FCSM (fermented by Candida tropicalis) replacing the soybean meal (FCSM group). The results showed that both abdominal fat content and subcutaneous fat thickness significantly reduced (p < 0.05) in response to dietary FCSM supplementation at the age of 21 d. Serum concentrations of glucose, triglyceride, and low-density lipoprotein cholesterol decreased (p < 0.05) in FCSM fed broilers compared with CON fed broilers, while the levels of epinephrine and growth hormone in serum, liver and abdominal fat tissue were higher (p < 0.05) in FCSM than in CON fed broilers. The activity of hormone-sensitive esterase and lipoprotein lipase (LPL) in the liver and abdominal fat were higher (p < 0.05) in FCSM than CON group. Additionally, compared with the CON group (p < 0.05), the expression of peroxisome proliferator-activated receptor alpha and LPL genes were upregulated in the livers of FCSM group broilers. Gene expressions of hormone-sensitive lipase and LPL in the abdominal fat tissue were also upregulated (p < 0.05) with the broilers fed with FCSM diets. A total of 20 significantly different metabolites were obtained in the serum of different dietary FCSM supplemented fed broilers. The mainly altered pathways were clustered into organic acid metabolism, fatty acid metabolism, and amino acid metabolism. These results not only provide a better understanding of broilers’ lipid metabolism with FCSM but also can be helpful in further improvement of the broilers’ healthy production and utilization of FCSM.

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Consumption of Whey in Combination with Dairy Medium‐Chain Fatty Acids (MCFAs) may Reduce Lipid Storage due to Urinary Loss of Tricarboxylic Acid Cycle Intermediates and Increased Rates of MCFAs Oxidation

Abstract: The type of protein showed highest effect on the overall metabolic profiles, but ω-oxidation of MCFAs in the liver seemed to be the main reason for the observed reduction in body fat mass after consumption of high MCFAs, independent of type of protein.

Cited by 13 publications

References 57 publications

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination of the Saturated Fatty Acids in Dairy

Multiple low salinity stress modes provided novel insight into the metabolic response of Scylla paramamosain adapting to inland saline-alkaline water

Effect of Fermented Cottonseed Meal on the Lipid-Related Indices and Serum Metabolic Profiles in Broiler Chickens

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