Consumption of vegetables may reduce the risk of liver cancer: Results from a meta-analysis of case-control and cohort studies

Luo, Aijing; Wang, Fu-zhi; Luo, Dan; Hu, Dehua; Mao, Ping; Xie, Wenzhao; He, Xiaofeng; Kan, Wei; Wang, Yun

doi:10.1016/j.clinre.2014.08.003

Cited by 21 publications

(12 citation statements)

References 29 publications

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“…Tea is exceptionally rich in Mn, one cup of tea contributing as much as 1.3 mg of Mn 35 . Our findings are concordant with previous meta-analyses of vegetables, tea drinking in relation to liver cancer risk 12, 39, 40 . Gender may impact on Mn retention in body and time of the male retention was longer than female 41 , which may be the reason that stronger inverse association was observed between dietary Mn and liver cancer risk in men than women in our study.…”

Section: Discussionsupporting

confidence: 92%

“…35 Our findings are concordant with previous metaanalyses of vegetables, tea drinking in relation to liver cancer risk. 12,39,40 Gender may impact on Mn retention in body and time of the male retention was longer than female, 41 which may be the reason that stronger inverse association was observed between dietary Mn and liver cancer risk in men than women in our study. The DRI of Fe is 8 mg for adult men and postmenopausal women (>50 years) and 16 mg for premenopausal women.…”

Section: Discussionmentioning

confidence: 62%

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Dietary trace element intake and liver cancer risk: Results from two population‐based cohorts in China

Yang

et al. 2016

Intl Journal of Cancer

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Dietary factors have been hypothesized to affect the risk of liver cancer via various mechanisms, but the influence has not been well studied and the evidence is conflicting. We investigated associations of dietary trace element intake, assessed through a validated food frequency questionnaire, with risk of liver cancer in two prospective cohort studies of 132,765 women (1997–2013) and men (2002–2013) in Shanghai, China. The associations were first evaluated in cohort studies and further assessed in a case-control study nested within these cohorts adjusting for hepatitis B virus infection. For cohort analyses, Cox proportional hazard models were used to estimate hazard ratios and 95% confidence intervals. For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% confidence intervals. After a median follow-up time of 15.2 years for the Shanghai Women’s Health Study and 9.3 years for the Shanghai Men’s Health Study, 192 women and 344 men developed liver cancer. Dietary intake of manganese was inversely associated with liver cancer risk (highest vs. lowest quintile, HR = 0.51, 95% CI: 0.35–0.73; ptrend = 0.001). Further adjustment for hepatitis B virus infection in the nested case-control study yielded a similar result (highest vs. lowest quintile, OR = 0.38, 95% CI: 0.21–0.69; ptrend < 0.001). No significant associations were found between dietary intake of selenium, iron, zinc, copper and liver cancer risk. The results suggest that higher intake of manganese may be associated with a lower risk of liver cancer in China.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 62%

Dietary trace element intake and liver cancer risk: Results from two population‐based cohorts in China

Yang

et al. 2016

Intl Journal of Cancer

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“…[17] Publication bias was evaluated by Egger test and the threshold was set as P < 0.05. [18] Moreover, the sensitivity analysis was evaluated by “leave one out” method with I 2 > 50% as the criterion. [18] …”

Section: Methodsmentioning

confidence: 99%

“…[18] Moreover, the sensitivity analysis was evaluated by “leave one out” method with I 2 > 50% as the criterion. [18] …”

Section: Methodsmentioning

confidence: 99%

Reducing effect of aerobic exercise on blood pressure of essential hypertensive patients

Wen

Wang

2017

Medicine

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Background:The comprehensive meta-analysis aimed to explore the reductive effect of aerobic exercise on blood pressure of hypertensive patients.Methods:The related researches were selected from PubMed and Embase databases up to June 2016. Based on specific inclusive criteria, the eligible studies were selected, and the heterogeneities in their results were estimated by χ2-based Q-test and I2 statistics. Quantitative meta-analysis was assessed by R 3.12 software, and results were presented by standardized mean difference (SMD) and their 95% confidence intervals (CIs). Outcome indicators were systolic blood pressure (SBP) and diastolic blood pressure (DBP). The publication biases were estimated by Egger test. Besides, the “leave one out” method was used for sensitivity evaluations.Results:As a result, a total of 13 papers with 802 samples were included. Based on the meta-analysis results, there were no significant differences in SBP and DBP between aerobic and control groups before exercise (SMD = 0.15, 95%CI: −0.16–0.46; SMD = 0.16, 95% CI: −0.23–0.55). However, significant reductions were obviously in aerobic group after aerobics, compared with control (SMD = −0.79, 95% CI: −1.29 to −0.28; SMD = −0.63, 95% CI: −1.14 to −0.12). A significant publication bias was detected in SBP (t = −2.2314, P = 0.04549) but not in DBP (t = −1.4962, P = 0.1604). Additionally, the DBP result would be altered after the exclusion of 2 individual papers.Conclusion:Aerobic exercise may be a potential nonpharmacological treatment for blood pressure improvement in essential hypertensive patients.

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“…Publication bias was assessed by Egger's test. [14] A trim and fill method was used for correction if there were significantly publication bias. [15] Finally, sensitivity analysis was conducted by omitting each study at a time to estimate the effect of each study on the overall ES.…”

Section: Methodsmentioning

confidence: 99%

Meta-analysis for outcomes of acute kidney injury after cardiac surgery

Shi

Liang²,

Mu³

et al. 2016

Medicine

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Consumption of vegetables may reduce the risk of liver cancer: Results from a meta-analysis of case-control and cohort studies

Cited by 21 publications

References 29 publications

Dietary trace element intake and liver cancer risk: Results from two population‐based cohorts in China

Dietary trace element intake and liver cancer risk: Results from two population‐based cohorts in China

Reducing effect of aerobic exercise on blood pressure of essential hypertensive patients

Meta-analysis for outcomes of acute kidney injury after cardiac surgery

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