Consumption of thermally oxidized palm oil diets alters biochemical indices in rats

Abstract

Thermally oxidized palm oil Liver function markers Lipid profile Malondialdehyde a b s t r a c t Palm oil is thermally oxidized to increase its palatability and this has been a usual practice in most homes. This study sought to assess the biochemical responses of rats to thermally oxidized palm oil diets. Therefore, Wistar strain albino rats (Rattus norveigicus) were fed with fresh palm oil (control) and thermally oxidized palm oil (test groups) diets and water ad libitum for 30 days. Then, the malondialdehyde (MDA) contents and total protein of the plasma and liver were determined. Subsequently, the plasma liver function markers [alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), albumin (ALB) and total bilirubin (TBIL) ] and the lipid profile [triglyceride (TRIG), total cholesterol (T-CHOL), high density lipoprotein (HDL-CHOL) and low density lipoprotein (LDL-CHOL) ] were assayed. The results of the study revealed that there was a significant decrease (P < 0.05) in the plasma and liver total protein, ALB, TRIG and HDL-CHOL of the test groups when compared with the control. Conversely, there was a significant increase (P < 0.05) in the activities of ALT, AST and ALP, TBIL, T-CHOL, LDL-CHOL and plasma/liver MDA of the test groups when compared with the control. These effects were most pronounced in rats fed with 20 min-thermally oxidized palm oil diet. Hence, consumption of thermally oxidized palm oil diets had deleterious effects on biochemical indices in rats. Therefore, cooking with and/or consumption of palm oil subjected to heat treatment for several long periods of time should be discouraged in our homes as this might have deleterious effects on human health.

The Effects of Frying Oils Supplemented with Vitamin E on Blood Parameters and Growth Performance of Rats

“…Shafeizadeh and his team [5] explained their results as the following: low uptake of linoleic acid, and a protective mechanism against the stress caused by oxidation. Additionally, results of the current study contradict findings of Falade et al [18], who found that Wistar rats fed thermally oxidized plam oil for 30 days showed significant decrease in the plasma and liver levels of HDL-C and TAG. It is worth to mention that results of this current study were based on short-term (90 days) impacts of oxidized oil and antioxidant on rats.…”

Remedial role of exercise training to deep‐fried oil‐induced metabolic and histological changes in Wistar rats

“…These alterations were also verified by the histological changes in heart tissue ( Figure 6). Pinckard, Baskin, and Stanford (2019) as a result of injury (Falade, Oboh, Ademiluyi, & Odubanjo, 2015;Giannini, Testa, & Savarino, 2005). In the present study, consumption of repeatedly fried vegetable oil increased the level of these biomarkers.…”

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

“…These findings are based on the effects of repeated heating on oils, including increased fatty acid instability and saturation, hyperlipidemic activity and depreciated level of tocopherols that protect biological membranes against oxidative and carcinogenic stress (Falade et al, 2015;Jaarin and Kamisah, 2012). Oxidized lipids in heated oil acquire undesirable properties associated with saturated fatty acids to promote correlation with increased serum cholesterol levels and higher LDL-cholesterol in particular (Jaarin et al, 2011).…”