Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct

Romaguera, Dora; Norat, Teresa; Wark, Petra A.; Vergnaud, Anne Claire; Schulze, Matthias B.; Woudenbergh, Geertruida J. van; Drogan, Dagmar; Amiano, Pilar; Molina‐Montes, Esther; Sánchez, María José; Balkau, Beverley; Barricarte, Aurelio; Beulens, J. W. J.; Clavel‐Chapelon, Françoise; Crispim, Sandra Patrícia; Fagherazzi, Guy; Franks, Paul W.; Grote, Verena A.; Huybrechts, Inge; Kaaks, Rudolf; Key, Timothy J.; Khaw, Kay‐Tee; Nilsson, Peter M.; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Quiŕos, J. Ramón; Rolandsson, Olov; Sacerdote, Carlotta; Sieri, Sabina; Slimani, Nadia; Spijkerman, Annemieke M.W.; Tjønneland, Anne; Tormo, María José; Tumino, Rosario; Berg, Sophie; Wermeling, Paulien R.; Zamora-Ros, Raúl; Feskens, Edith J. M.; Langenberg, Claudia; Sharp, Stephen J.; Forouhi, Nita G.; Riboli, Elio; Wareham, Nicholas J.

doi:10.1007/s00125-013-2899-8

Cited by 229 publications

(130 citation statements)

References 28 publications

(47 reference statements)

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“…Another possibility is that the increased risk is mediated by increases in overweight (32). In line with previous studies on type 2 diabetes (1,3,5,7,8), the observed positive association remained after adjustment for BMI, possibly suggesting a direct adverse effect of sweetened beverage intake on glucose homeostasis. However, it could be that the BMI does not fully indicate the level of visceral fat, which is a predictor of type 2 diabetes (33).…”

Section: Discussionsupporting

confidence: 85%

“…Sugar-sweetened beverage intake has been linked to increased risk of type 2 diabetes in numerous studies (1,2,3,4,5,6); the most recent meta-analysis found that the risk increases by 13% for an increment of each serving per day in intake (7). Suggested routes by which sugar-sweetened beverages may influence diabetes risk are through glycemic or insulinemic responses or by contributing to excessive energy intake (8,9).…”

Section: Introductionmentioning

confidence: 99%

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Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes

Löfvenborg

Andersson

Carlsson

et al. 2016

European Journal of Endocrinology

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Objective: Sweetened beverage intake is associated with increased risk of type 2 diabetes, but its association with autoimmune diabetes is unclear. We aimed to investigate sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA); autoimmune diabetes with features of type 2 diabetes. Design/methods: Data from a Swedish population-based study was used, including incident cases of LADA (n = 357) and type 2 diabetes (n = 1136) and randomly selected controls (n = 1371). Diabetes classification was based on onset age (≥35), glutamic acid decarboxylase autoantibodies (GADA) and C-peptide. Sweetened beverage intake information was derived from a validated food frequency questionnaire. ORs adjusted for age, sex, family history of diabetes, education, lifestyle, diet, energy intake and BMI were estimated using logistic regression. Results: Daily intake of >2 servings of sweetened beverages (consumed by 6% of participants) was associated with increased risk of LADA (OR: 1.99, 95% CI: 1.11-3.56), and for each 200 mL daily serving, OR was 1.15 (95% CI: 1.02-1.29). Findings were similar for sugar-sweetened (OR: 1.18, 95% CI: 1.00-1.39) and artificially sweetened beverages (OR: 1.12, 95% CI: 0.95-1.32). Similarly, each daily serving increment in total sweetened beverage conferred 20% higher type 2 diabetes risk (95% CI: 1.07-1.34). In type 2 diabetes patients, high consumers displayed higher HOMA-IR levels (4.5 vs 3.5, P = 0.0002), but lower HOMA-B levels (55 vs 70, P = 0.0378) than non-consumers. Similar tendencies were seen in LADA. Conclusions: High intake of sweetened beverages was associated with increased risk of LADA. The observed relationship resembled that with type 2 diabetes, suggesting common pathways possibly involving insulin resistance.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes

Löfvenborg

Andersson

Carlsson

et al. 2016

European Journal of Endocrinology

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“…The InterAct consortium evaluated the association of the consumption of sweet beverages (juices and nectars, sugar-sweetened soft drinks and artificially sweetened soft drinks) with T2D incidence in European adults [48]. The investigators established a case-cohort study including 12,403 incident T2D cases and a stratified subcohort of 16,154 participants selected from eight European cohorts participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.…”

Section: Scientific Evaluationmentioning

confidence: 99%

The Impact of the Bellagio Report on Healthy Agriculture, Healthy Nutrition, Healthy People: Scientific and Policy Aspects and the International Network of Centers for Genetics, Nutrition and Fitness for Health

Simopoulos

2014

Lifestyle Genomics

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The Bellagio Report on Healthy Agriculture, Healthy Nutrition, Healthy People was the result of a meeting held at the Rockefeller Foundation Bellagio Center in the fall of 2012. The meeting was science based but policy oriented. The Bellagio Report concluded that: (1) sugar consumption, especially in the form of high-energy fructose in soft drinks, poses a major and insidious health threat, particularly for children; (2) current diets in most populations, albeit with regional differences, are deficient in omega-3 fatty acids but too high in omega-6 fatty acid intake, and (3) not all calories are the same since calories from different sources (i.e. glucose or fructose or omega-6 or omega-3 fatty acids) have different metabolic and neurohormonal effects. This paper summarizes the scientific progress and policy actions that have occurred in these three areas. Genetic variation in populations and gene-nutrient interactions are fundamental concepts that need to be taken into consideration in growth and development and in the prevention and management of chronic noncommunicable diseases since there is enormous variation in both the frequency of genetic variants and dietary composition worldwide. Furthermore, this paper updates the Bellagio Report in terms of the scientific and policy aspects, both of which have expanded over the past 2 years, and describes the progress made in establishing an International Network of Centers for Genetics, Nutrition and Fitness for Health.

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“…High intake of these foods is associated with the nutritional transition toward ever growing prevalences of overweight and obesity in children 2 , and obesity and diabetes in adults 3 . Associations between sugar intake from beverages and weight gain 4 , type 2 diabetes [5][6][7] , cardiovascular disease, and metabolic syndrome have been reported 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary high fructose corn syrup on regulation of energy intake and leptin gene expression in rats

et al. 2015

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OBJECTIVE: To evaluate in Wistar rats the effect of chronic use of high fructose corn syrup on serum lipids, body weight, energy intake regulation, and expression of associated genes. METHODS: For 11 weeks, male rats were fed a standard diet with either water (control) or 15% high fructose corn syrup solution, or fed a high-fat diet. The rats' food intake and body weight were measured weekly. Expression of leptin and fatty acid synthase genes was quantified in their brain and adipose tissue upon sacrifice at age 119 days using real-time polymerase chain reaction. RESULTS: The intake of 15% high fructose corn syrup did not affect the rats' weight, only the rats on the high-fat diet gained significant weight. The rats in both diets had lower levels of leptin expression and high levels of fatty acid synthase in the brain, which were associated with high serum triglycerides. CONCLUSION: Fifteen percent high fructose corn syrup intake and the high-fat diet reduced leptin gene expression in the brain of Wistar rats, with differential effects on weight gain.

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Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct

Cited by 229 publications

References 28 publications

Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes

Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes

The Impact of the Bellagio Report on Healthy Agriculture, Healthy Nutrition, Healthy People: Scientific and Policy Aspects and the International Network of Centers for Genetics, Nutrition and Fitness for Health

Effects of dietary high fructose corn syrup on regulation of energy intake and leptin gene expression in rats

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