Consumption of spicy foods and the prevalence of irritable bowel syndrome

Esmaillzadeh, Ahmad; Keshteli, Ammar Hassanzadeh; Hajishafiee, Maryam; Feizi, Awat; Feinle‐Bisset, Christine; Adibi, Peyman

doi:10.3748/wjg.v19.i38.6465

Cited by 45 publications

(35 citation statements)

References 25 publications

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“…Although MCs can secrete and synthesise serotonin from tryptophan and serotonin is a chemotactic molecule for MCs,25 and some adverse reactions to diet in FGIDs involve foods containing serotonin, including cheese, meat, soya beans, cereals, nuts and vegetables,26 the role of MCs in such responses, if any, is mostly ignored. Finally, spice intake correlates directly with the likelihood of developing IBS in females 27. Spicy foods contain capsaicin, the natural ligand of transient receptor potential vanilloid 1 (TRPV1) receptors on nociceptive afferent C-fibres.…”

Section: Factors and Mechanisms Underlying MC Activation In The Gutmentioning

confidence: 99%

The role of mast cells in functional GI disorders

Wouters

Vicario

Santos

2015

Gut

264

237

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Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity. The two most prevalent FGIDs, affecting up to 16-26% of worldwide population, are functional dyspepsia and irritable bowel syndrome. Their etiopathogenic mechanisms remain unclear, however, recent observations reveal low-grade mucosal inflammation and immune activation, in association with impaired epithelial barrier function and aberrant neuronal sensitivity. These findings come to challenge the traditional view of FGIDs as pure functional disorders, and relate the origin to a tangible organic substrate. The mucosal inflammatory infiltrate is dominated by mast cells, eosinophils and intraepithelial lymphocytes in the intestine of FGIDs. It is well established that mast cell activation can generate epithelial and neuro-muscular dysfunction and promote visceral hypersensitivity and altered motility patterns in FGIDs, postoperative ileus, food allergy and inflammatory bowel disease. This review will discuss the role of mucosal mast cells in the gastrointestinal tract with a specific focus on recent advances in disease mechanisms and clinical management in irritable bowel syndrome and functional dyspepsia.

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Section: Factors and Mechanisms Underlying MC Activation In The Gutmentioning

confidence: 99%

The role of mast cells in functional GI disorders

Wouters

Vicario

Santos

2015

Gut

264

237

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“…Thus, there is substantial evidence that the HLS, incorporating factors, including dietary intake, dietary habits, physical activity, psychological distress, and smoking status, can accurately predict the risk of other diseases. Moreover, associations between individual items of the score with IBS have been investigated previously, and such associations between single factors of the score and diseases can be considered as an equivalent strategy to validate the score . The cross‐sectional nature of this study does not allow conclusions regarding any causal relationships between the HLS and IBS.…”

Section: Discussionmentioning

confidence: 99%

“…Increasing levels of stress and anxiety disorders are other risk factors for developing IBS among Iranian adults . Moreover, the traditional Iranian diet consists of large amounts of spicy foods, which are associated with an increased risk of IBS . A high prevalence of IBS, combined with a poor quality of life in patients with IBS, poses a considerable economic burden to healthcare systems …”

Section: Introductionmentioning

confidence: 99%

“…In particular, lifestyle factors, including nutritional status, physical activity, and psychological distress, play a major role in developing IBS . Observational studies have shown that specific food groups, including wheat‐based cereals, dairy products, fatty, spicy and processed foods, coffee, and alcohol, and low intakes of vegetables, legumes, and fruits may be related to symptoms in IBS . Moreover, irregular meal patterns and meal‐skipping have been found to be associated with IBS .…”

Section: Introductionmentioning

confidence: 99%

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Healthy lifestyle score and irritable bowel syndrome: A cross‐sectional study in adults

Hajishafiee

Keshteli

Saneei

et al. 2020

Neurogastroenterology Motil

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Background: Lifestyle modifications play an important role in the management of irritable bowel syndrome (IBS), but there is limited information on any associations of combined lifestyle-related factors with IBS in Middle Eastern populations. We, therefore, assessed the associations of a "lifestyle score," in analogy to lifestyle scores applied in studies of other disorders, with IBS in adults. Methods:In a cross-sectional study on 3363 Iranian adults, a healthy lifestyle score (HLS) was constructed using information about dietary habits, dietary intake, physical activity, smoking status, and psychological distress, which was collected using validated questionnaires. A modified version of the Rome III questionnaire (in Persian) was used to diagnose IBS and its subtypes.Key Results: Individuals with the highest HLS had a 65% lower odds of having IBS compared with those in the lowest category (OR: 0.35; 95% CI: 0.26-0.48).Participants with healthy dietary habits, including regular meal pattern, slow/moderate eating rate, moderate intra-meal fluid consumption, moderate/long meal-to-sleep interval, and low/moderate consumption of fatty foods, had significantly lower odds of having IBS compared with those with unhealthy dietary habits (OR: 0.81; 95% CI: 0.69-0.96). Moreover, individuals with lower levels of psychological distress, compared with those with higher levels of distress, had significantly lower odds of IBS (OR: 0.49; 95% CI: 0.40-0.60). Conclusions and Inferences:Our data suggest that having an overall "healthy lifestyle" is related to substantially reduced odds of IBS, suggesting that adhering to a healthy lifestyle pattern, including dietary habits, diet quality, physical activity, smoking, and psychological distress, can be considered as a key management strategy for IBS. K E Y W O R D Sdietary habit, dietary intake, physical activity, psychological distress, smoking

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“…The meals were comparatively irregular in patients with IBS, a factor which has been suggested to be associated with exacerbation of symptoms. [2526]…”

Section: Discussionmentioning

confidence: 99%

Comparison of psychiatric morbidity in patients with irritable bowel syndrome and non-ulcer dyspepsia

et al. 2016

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Background and Aims:The present study aimed to find psychiatric morbidity, stress, anxiety, and depression in patients with irritable bowel syndrome (IBS) and compare it with patients having non-ulcer dyspepsia (NUD).Methods:This case NUD study compared 50 patients each with IBS and NUD. The two groups were compared on demographic data, psychiatric diagnosis using the Structured Clinical Interview for DSM-IV Axis 1 disorders, anxiety levels using the Hamilton Anxiety Rating Scale (HAM-A), and depression using the Hamilton Depression Rating Scale (HAM-D). The Presumptive Stressful Life Events Scale (PSLES) was used to measure stress.Results:The cases of IBS were more likely to be of female gender (P = 0.012), married (P = 0.009), and employed (P < 0.001). Psychiatric diagnoses were more common in the cases of IBS than NUDs (88% vs. 30%, P < 0.001), the most common being major depression and somatization disorder. Symptoms of anxiety and depression were more common in patients with IBS (P < 0.001 for HAM-A and HAM-D). Logistic regression revealed that having IBS and increased age were independent predictors of having a psychiatric diagnosis.Conclusions:IBS is associated with the considerable degree of psychiatric morbidity. Adequate attention should be paid toward comorbid psychiatric illnesses, and prompt treatment should be instituted.

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Consumption of spicy foods and the prevalence of irritable bowel syndrome

Cited by 45 publications

References 25 publications

The role of mast cells in functional GI disorders

The role of mast cells in functional GI disorders

Healthy lifestyle score and irritable bowel syndrome: A cross‐sectional study in adults

Comparison of psychiatric morbidity in patients with irritable bowel syndrome and non-ulcer dyspepsia

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