Consumption of Soft Drinks With Phosphoric Acid As a Risk Factor for the Development of Hypocalcemia in Postmenopausal Women

Guerrero-Romero, Fernando; Rodríguez-Morán, Martha; Evangelina, Reyes

doi:10.1016/s0895-4356(99)00097-9

Cited by 39 publications

(28 citation statements)

References 12 publications

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“…Few studies have examined this in adults. Higher PTH and hyperphosphaturia have been reported in postmenopausal women with low serum calcium (ͨ8.8 mg Ca/dL compared with 8.8 mg Ca/dL), and the women with low serum calcium were significantly more likely to consume ͧ1 cola/d (odds ratio: 1.28; 95% CI: 1.06, 1.53) (26). However, Kim et al (35) did not find associations between carbonated beverage consumption and BMD in 1000 women aged 44 -98 y.…”

Section: Discussionmentioning

confidence: 97%

“…Although caffeine likely contributes to lower BMD, the result also observed for decaffeinated cola, the lack of difference in total caffeine intake across cola intake groups, and the lack of attenuation after adjustment for caffeine content suggest that caffeine does not explain these results. A deleterious effect of phosphoric acid has been proposed (26). Cola beverages contain phosphoric acid, whereas other carbonated soft drinks (with some exceptions) do not.…”

Section: Discussionmentioning

confidence: 99%

“…In another study, cola was given to ovariectomized rats; subsequent hypocalcemia and loss of femoral BMD was observed in the rats relative to a control group (31). Several studies have examined the association between carbonated beverages and fracture (4,32,33), hypocalcemia (26,34), or BMD (5, 6) in children. Wyshak et al (32) found a 1.4 (1.1-1.6) greater risk of fracture in former athletes and a 3-fold risk in adolescent girls who consumed carbonated beverages compared with those who did not (4).…”

Section: Discussionmentioning

confidence: 99%

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Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study

Tucker

Morita

Qiao

et al. 2006

The American Journal of Clinical Nutrition

212

143

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Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study 1Ϫ3Katherine L Tucker, Kyoko Morita, Ning Qiao, Marian T Hannan, L Adrienne Cupples, and Douglas P Kiel ABSTRACT Background: Soft drink consumption may have adverse effects on bone mineral density (BMD), but studies have shown mixed results. In addition to displacing healthier beverages, colas contain caffeine and phosphoric acid (H 3 PO 4 ), which may adversely affect bone. Objective: We hypothesized that consumption of cola is associated with lower BMD. Design: BMD was measured at the spine and 3 hip sites in 1413 women and 1125 men in the Framingham Osteoporosis Study by using dual-energy X-ray absorptiometry. Dietary intake was assessed by food-frequency questionnaire. We regressed each BMD measure on the frequency of soft drink consumption for men and women after adjustment for body mass index, height, age, energy intake, physical activity score, smoking, alcohol use, total calcium intake, total vitamin D intake, caffeine from noncola sources, season of measurement, and, for women, menopausal status and estrogen use. Results: Cola intake was associated with significantly lower (P 0.001-0.05) BMD at each hip site, but not the spine, in women but not in men. The mean BMD of those with daily cola intake was 3.7% lower at the femoral neck and 5.4% lower at Ward's area than of those who consumed 1 serving cola/mo. Similar results were seen for diet cola and, although weaker, for decaffeinated cola. No significant relations between noncola carbonated beverage consumption and BMD were observed. Total phosphorus intake was not significantly higher in daily cola consumers than in nonconsumers; however, the calcium-to-phosphorus ratios were lower. Conclusions: Intake of cola, but not of other carbonated soft drinks, is associated with low BMD in women. Additional research is needed to confirm these findings.Am J Clin Nutr 2006;84: 936 -42.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study

Tucker

Morita

Qiao

et al. 2006

The American Journal of Clinical Nutrition

212

143

View full text Add to dashboard Cite

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“…Furthermore, compared to women who did not consume any beverages, the excessive consumption of soft drinks containing phosphoric acid by postmenopausal women caused hypocalcemia and increased the PTH serum levels (Fernando et al, 1999). High phosphate intake also decreases the levels of a bone formation marker, bone-specific alkaline phosphatase.…”

Section: Influence Of Pi On Bone Resorption In Humansmentioning

confidence: 99%

Biological effects of inorganic phosphate: potential signal of toxicity

et al. 2015

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-Inorganic phosphate (Pi) plays crucial roles in several biological processes and signaling pathways. Pi uptake is regulated by sodium-dependent phosphate (Na/Pi) transporters (NPTs). Moreover, Pi is used as a food additive in food items such as sausages, crackers, dairy products, and beverages. However, the high serum concentration of phosphate (> 5.5 mg/dL) can cause adverse renal effects, cardiovascular effects including vascular or valvular calcification, and stimulate bone resorption. In addition, Pi can also alter vital cellular signaling, related to cell growth and cap-dependent protein translation. Moreover, intake of dietary Pi, whether high (1.0%) or low (0.1%), affects organs in developing mice, and is related to tumorigenesis in mice. The recommended dietary allowance (RDA) of Pi is the daily dietary intake required to maintain levels above the lower limit of the range of normal serum Pi concentration (2.7 mg/dL) for most individuals (97-98%). Thus, adequate intake of Pi (RDA; 700 mg/day) and maintenance of normal Pi concentration (2.7-4.5 mg/dL) are important for health and prevention of diseases caused by inadequate Pi intake.

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“…One case-control study found that postmenopausal women with hypocalcemia were signifi cantly more likely to report daily consumption of phosphoric acid-containing soft drinks relative to control subjects with normal concentrations of serum calcium [46]. Another study did not fi nd associations between carbonated beverage consumption and BMD in postmenopausal women, but cola consumption was quite low in that population [47].…”

Section: Colamentioning

confidence: 99%

Osteoporosis prevention and nutrition

Tucker

2009

Curr Osteoporos Rep

126

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Although calcium and vitamin D have been the primary focus of nutritional prevention of osteoporosis, recent research has clarified the importance of several additional nutrients and food constituents. Further, results of calcium and vitamin D supplementation trials have been inconsistent, suggesting that reliance on this intervention may be inadequate. In addition to dairy, fruit and vegetable intake has emerged as an important modifiable protective factor for bone health. Several nutrients, including magnesium, potassium, vitamin C, vitamin K, several B vitamins, and carotenoids, have been shown to be more important than previously realized. Rather than having a negative effect on bone, protein intake appears to benefit bone status, particularly in older adults. Regular intake of cola beverages shows negative effects and moderate alcohol intake shows positive effects on bone, particularly in older women. Current research on diet and bone status supports encouragement of balanced diets with plenty of fruit and vegetables, adequate dairy and other protein foods, and limitation of foods with low nutrient density.

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Consumption of Soft Drinks With Phosphoric Acid As a Risk Factor for the Development of Hypocalcemia in Postmenopausal Women

Cited by 39 publications

References 12 publications

Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study

Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study

Biological effects of inorganic phosphate: potential signal of toxicity

Osteoporosis prevention and nutrition

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