Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in children: A case-control study

Mazariegos-Ramos, E.; Guerrero-Romero, Fernando; Rodríguez-Morán, Martha; Lazcano-Burciaga, Gloria; Paniagua, Ramón; Amato, Dante

doi:10.1016/s0022-3476(95)70215-6

Cited by 59 publications

(28 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As for the acidulant phosphoric acid, present in Colaflavored soft drinks, Mazariegos-Ramos et al (1995) confirmed, in children, the relationship between the consumption of soft drinks with phosphoric acid and the risk of development of hypocalcemia, a disease that results in a low concentration of calcium in the blood, which can cause tetanus, subnormal intelligence, depression, and cardiovascular problems among others.…”

Section: Chromosomal Aberration Testmentioning

confidence: 87%

Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents

et al. 2013

View full text Add to dashboard Cite

Due to the large consumption of soft drinks in Brazil and worldwide in recent years and considering that some of the components present in their composition pose potential risks to human health, the aim of this study was to evaluate the cytotoxic and mutagenic potential of specific cola and grape-flavored soft drink brands. Bone marrow cells of Wistar rats were initially treated by gavage with one single dose of Cola or Grape soft drink, which was next offered ad libitum (instead of water) for 24 hours. A negative control treatment was performed by administering one single dose of water and a positive control administering cyclophosphamide intraperitoneally. Statistical analysis showed that the Cola and Grape soft drinks studied were not cytotoxic. However, the Cola soft drink proved mutagenic in this experiment treatment time. Therefore, this study serves as a warning about the consumption of Cola-flavored soft drink and for the need for further subchronic and chronic studies on soft drinks in order to evaluate the long term mutagenic and cytotoxic effects of these substances.

show abstract

Section: Chromosomal Aberration Testmentioning

confidence: 87%

Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In another study, cola was given to ovariectomized rats; subsequent hypocalcemia and loss of femoral BMD was observed in the rats relative to a control group (31). Several studies have examined the association between carbonated beverages and fracture (4,32,33), hypocalcemia (26,34), or BMD (5, 6) in children. Wyshak et al (32) found a 1.4 (1.1-1.6) greater risk of fracture in former athletes and a 3-fold risk in adolescent girls who consumed carbonated beverages compared with those who did not (4).…”

Section: Discussionmentioning

confidence: 99%

Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study

Tucker

Morita

Qiao

et al. 2006

The American Journal of Clinical Nutrition

212

143

View full text Add to dashboard Cite

Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study 1Ϫ3Katherine L Tucker, Kyoko Morita, Ning Qiao, Marian T Hannan, L Adrienne Cupples, and Douglas P Kiel ABSTRACT Background: Soft drink consumption may have adverse effects on bone mineral density (BMD), but studies have shown mixed results. In addition to displacing healthier beverages, colas contain caffeine and phosphoric acid (H 3 PO 4 ), which may adversely affect bone. Objective: We hypothesized that consumption of cola is associated with lower BMD. Design: BMD was measured at the spine and 3 hip sites in 1413 women and 1125 men in the Framingham Osteoporosis Study by using dual-energy X-ray absorptiometry. Dietary intake was assessed by food-frequency questionnaire. We regressed each BMD measure on the frequency of soft drink consumption for men and women after adjustment for body mass index, height, age, energy intake, physical activity score, smoking, alcohol use, total calcium intake, total vitamin D intake, caffeine from noncola sources, season of measurement, and, for women, menopausal status and estrogen use. Results: Cola intake was associated with significantly lower (P 0.001-0.05) BMD at each hip site, but not the spine, in women but not in men. The mean BMD of those with daily cola intake was 3.7% lower at the femoral neck and 5.4% lower at Ward's area than of those who consumed 1 serving cola/mo. Similar results were seen for diet cola and, although weaker, for decaffeinated cola. No significant relations between noncola carbonated beverage consumption and BMD were observed. Total phosphorus intake was not significantly higher in daily cola consumers than in nonconsumers; however, the calcium-to-phosphorus ratios were lower. Conclusions: Intake of cola, but not of other carbonated soft drinks, is associated with low BMD in women. Additional research is needed to confirm these findings.Am J Clin Nutr 2006;84: 936 -42.

show abstract

“…In healthy premenopausal women, the consumption of high levels of dietary phosphate additives resulted in lower serum calcium concentrations and in higher serum PTH concentrations than those found in the group consuming only natural phosphorus (Kemi et al, 2009 ing phosphoric acid was found to be closely related to the development of hypocalcemia (Mazariegos-Ramos et al, 1995). Furthermore, compared to women who did not consume any beverages, the excessive consumption of soft drinks containing phosphoric acid by postmenopausal women caused hypocalcemia and increased the PTH serum levels (Fernando et al, 1999).…”

Section: Influence Of Pi On Bone Resorption In Humansmentioning

confidence: 98%

Biological effects of inorganic phosphate: potential signal of toxicity

et al. 2015

View full text Add to dashboard Cite

-Inorganic phosphate (Pi) plays crucial roles in several biological processes and signaling pathways. Pi uptake is regulated by sodium-dependent phosphate (Na/Pi) transporters (NPTs). Moreover, Pi is used as a food additive in food items such as sausages, crackers, dairy products, and beverages. However, the high serum concentration of phosphate (> 5.5 mg/dL) can cause adverse renal effects, cardiovascular effects including vascular or valvular calcification, and stimulate bone resorption. In addition, Pi can also alter vital cellular signaling, related to cell growth and cap-dependent protein translation. Moreover, intake of dietary Pi, whether high (1.0%) or low (0.1%), affects organs in developing mice, and is related to tumorigenesis in mice. The recommended dietary allowance (RDA) of Pi is the daily dietary intake required to maintain levels above the lower limit of the range of normal serum Pi concentration (2.7 mg/dL) for most individuals (97-98%). Thus, adequate intake of Pi (RDA; 700 mg/day) and maintenance of normal Pi concentration (2.7-4.5 mg/dL) are important for health and prevention of diseases caused by inadequate Pi intake.

show abstract

Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in children: A case-control study

Cited by 59 publications

References 9 publications

Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents

Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents

Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: The Framingham Osteoporosis Study

Biological effects of inorganic phosphate: potential signal of toxicity

Contact Info

Product

Resources

About