Consumption of salted meat and its interactions with alcohol drinking and tobacco smoking on esophageal squamous-cell carcinoma

Lin, Sihao; Wang, Xiaorong; Huang, Chunjun; Li, Xudong; Zhao, Jin; Yu, Ignatius Tak-sun; Christiani, David C.

doi:10.1002/ijc.29406

Cited by 54 publications

(28 citation statements)

References 32 publications

(92 reference statements)

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“…In the present study, results demonstrated that the expression level of SBF2-AS1 was associated with smoking and drinking history, tumor size and TNM stage. Previous studies confirmed that smoking and drinking are significantly poor prognostic risk factors of ESCC (32,33). Chang et al (34) revealed that within a Chinese population sex, age, smoking and drinking status are associated with an increased risk of ESCC in 9,805 cases and 10,493 controls.…”

Section: Discussionmentioning

confidence: 90%

Upregulated long non-coding RNA SBF2-AS1 promotes proliferation in esophageal squamous cell carcinoma

et al. 2018

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Abstract. Esophageal cancer is one of the most common types of malignant tumors located within the digestive system, with >50% of esophageal cancer cases worldwide occurring in China. Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are frequently dysregulated in cancer; however, few lncRNAs have been characterized in esophageal squamous cell carcinoma (ESCC). In the present study, a novel lncRNA, SET-binding factor 2 (SBF2) antisense RNA1 (SBF2-AS1) was exhibited in ESCC. Expression levels of SBF2-AS1 in ESCC and adjacent non-cancerous tissues were detected using the reverse transcription-quantitative polymerase chain reaction. SBF2-AS1 was knocked down, and proliferation, migration, invasion, apoptosis and the cell cycle were examined in ESCC cells. Results identified that SBF2-AS1 was significantly upregulated in ESCC compared with adjacent non-cancerous tissues (fold increase, 8.82; P= 0.023). The SBF2-AS1 expression level was significantly increased in patients who had a smoking (9.927 vs. 4.507; P=0.030) and/or drinking (10.938 vs. 4.232; P=0.032) history. Patients with a large tumor size exhibited increased SBF2-AS1 expression (≥4 vs. <4 cm, 14.898 vs. 5.435; P=0.018). Patients with advanced ESCC exhibited increased upregulation of SBF2-AS1 [tumor-node-metastasis (TNM) I-II vs. TNM III-IV, 1.302 vs. 15.475; P<0.01]. SBF2-AS1 was also silenced using small interfering RNA. Cell proliferative and invasive ability were significantly inhibited (P<0.05) following SBF2-AS1 silencing, the cell cycle was arrested in the G 2 phase; however, there was no significant difference in the proportion of apoptotic cells. Gene Set Enrichment Analysis revealed that genes associated with cell cycle biological processes, including the cancer suppressor gene cyclin-dependent kinase 1A (CDKN1A), were significantly associated with SBF2-AS1 in ESCC tissues. Further validation confirmed that CDKN1A expression levels were increased in ECA-109 cells following SBF2-AS1 silencing. The results of the present study demonstrate that SBF2-AS1 is significantly upregulated in ESCC, and that silencing of SBF2-AS1 inhibits the proliferative and invasive ability of ESCC cells. SBF2-AS1 may be a novel biomarker and therefore a potential therapeutic target for ESCC. IntroductionHuman esophageal cancer (EC) is the third most common digestive system malignancy worldwide, and is associated with a high mortality rate (1). EC is also one of the most common malignant tumors in China, ranking third and Abbreviations: ESCC, esophageal squamous cell carcinoma; EA, esopha geal adenocarcinoma; ncRNA, non-coding RNA; lncRNA, long non-coding RNA; SBF2-AS1, SET-binding factor 2 antisense RNA 1; CCK-8, Cell Counting Kit-8; PRC2, Polycomb repressive complex 2; CDKN1A, cyclin-dependent kinase inhibitor 1A

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Section: Discussionmentioning

confidence: 90%

Upregulated long non-coding RNA SBF2-AS1 promotes proliferation in esophageal squamous cell carcinoma

et al. 2018

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“…A lot of environmental and genetic factors chronically interact, leading to oesophageal cancer development. Environmental risk factors for oesophageal cancer include cigarette smoking, alcohol drinking, dietary factors and exposure to carcinogens or their precursors (Lin et al, ; Song et al, ; Sun et al, ; Tran et al, ; Yang, ; Yang et al, ; Yokokawa et al, ). However, only a portion of exposed individuals develop oesophageal cancer, which suggests that genetic background may play an important role in oesophageal carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Association of cytotoxic T‐lymphocyte associated protein 4 gene polymorphisms with the risk and prognosis of oesophageal cancer in a high‐incidence region from northern China

Wang

et al. 2019

Int J Immunogenetics

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The most important anti‐tumour immune response is mediated by T lymphocytes. Cytotoxic T lymphocyte‐associated protein 4 (CTLA4) plays a critical role in the immune surveillance against tumours as an inhibitory immune checkpoint molecule of T‐cell activation. This study was designed to explore the association of CTLA4 polymorphisms with the susceptibility to oesophageal squamous cell carcinoma (ESCC) and prognosis of patients with ESCC in a high‐incidence population from northern China. CTLA4 rs5742909 C/T and rs231775 G/A single nucleotide polymorphisms (SNPs) were genotyped using polymerase chain reaction–ligase detection reaction (PCR‐LDR) method in 577 ESCC patients and 580 controls. Upper gastrointestinal cancer family history increased the risk of ESCC (the sex‐, age‐ and smoking status‐adjusted OR = 1.383, 95%CI = 1.094–1.749). The genotype frequencies of these two SNPs in the patients with ESCC were similar to that in the controls. Survival analyses were conducted in 204 patients with ESCC with five‐year survival information. The mean survival time of ESCC patients with rs231775 SNP A/A genotype in age over 60 years group was 23.2 months, significantly shorter than that of those with G/G genotype (47.3 months). The A/A genotype was associated with increased death risk of patients with ESCC older than 60 years (adjusted HR = 4.544, 95%CI = 1.913–10.790). CTLA4 rs231775 SNP might be used as genetic marker of worse prognosis for patients with ESCC over 60 years in a high‐incidence population from northern China.

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“…A recent population-based, case–control study in China reported that salted meat combined with alcohol drinking and smoking at least 10 times increased the risk for ESCC compared with salted meat consumption alone. 25 In our study, which was adjusted for confounders, participants who had dinner-to-bed time <3 hours and post-dinner nonwalk were at a 7.4-fold increased risk of developing GC (95% CIs = 4.532–13.16) compared with those with dinner-to-bed time ≥4 hours and post-dinner walk. However, those with dinner-to-bed time <3 hours who took post-dinner walk were 6.4 times less likely to develop GC (AOR = 1.148).…”

Section: Discussionmentioning

confidence: 65%

“… 24 Body mass index = weight (kg) divided by height (m) squared (body height and weight 5 years before interviewed). 25 Local environmental pollution was assessed as living in a residential area within 5 km of an environmental hazard, such as polluted air or water, etc. 26 …”

Section: Methodsmentioning

confidence: 99%

The Effects of Dinner-to-Bed Time and Post-Dinner Walk on Gastric Cancer Across Different Age Groups

Zhang

Lü

et al. 2016

Medicine

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Gastric cancer (GC) remains a major killer throughout the world. Despite the dramatic decrease in GC over the last century, its etiology has not yet been well characterized.This study investigated the possible independent and combined effects of the dinner-to-bed time and post-dinner walk on the risk for GC across different age groups.A population-based, case–control study was conducted in southeast China, including 452 patients with GC and 465 age-, race-, and gender-matched controls. A self-designed questionnaire was used to collect information on demographic characteristics, dinner-to-bed time, post-dinner walk, and other behavioral factors. Conditional logistic regression models were used to estimate the effects of the dinner-to-bed time and post-dinner walk as well as their joint effect on the risk for GC across different age groups.Individuals with dinner-to-bed time <3 hours were more prone to have GC (P < 0.001), and the shorter the dinner-to-bed time was, the higher was the risk for GC (Ptrend < 0.001). Post-dinner nonwalk was associated with a 2.9-fold increased risk for GC compared with post-dinner walk (adjusted odds ratio [AOR] = 2.942, 95% confidence intervals [95% CIs] = 2.072–4.179). The interaction effect of dinner-to-bed time and post-dinner walk on GC risk was detected (AOR = 1.862, 95% CIs = 1.584–3.885, synergy index [SI] = 2.654, 95% CIs = 2.27–3.912). Participants with dinner-to-bed time <3 hours who did not walk after dinner were 7.4 times likely to suffer from GC (AOR = 7.401, 95% CIs = 4.523–13.16) than those with dinner-to-bed time ≥4 hours who took such walk. The risk of GC due to dinner-to-bed time <3 hours, post-dinner nonwalk and their interaction was positively correlated with age. The strongest risk was observed among people ≥70 years old, but the effects were not significant for people ≤55 years old.Dinner-to-bed time <3 hours and post-dinner nonwalk are independent risk factors for GC; the synergistic interaction between the 2 factors was positively related to age, which might significantly increase the risk for GC among people >55 years old.

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Consumption of salted meat and its interactions with alcohol drinking and tobacco smoking on esophageal squamous-cell carcinoma

Cited by 54 publications

References 32 publications

Upregulated long non-coding RNA SBF2-AS1 promotes proliferation in esophageal squamous cell carcinoma

Upregulated long non-coding RNA SBF2-AS1 promotes proliferation in esophageal squamous cell carcinoma

Association of cytotoxic T‐lymphocyte associated protein 4 gene polymorphisms with the risk and prognosis of oesophageal cancer in a high‐incidence region from northern China

The Effects of Dinner-to-Bed Time and Post-Dinner Walk on Gastric Cancer Across Different Age Groups

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