Consumption of processed and ultra-processed foods by patients with stomach adenocarcinoma: a multicentric case–control study in the Amazon and southeast regions of Brazil

Peres, Stela Verzinhasse; Silva, Diego R. M.; Coimbra, Felipe José Fernández; Fagundes, Marcela A.; Auzier, Jamille J. N.; Pelosof, Adriane; Araújo, Marília Souto de; Assumpção, Paulo Pimentel de; Curado, María Paula

doi:10.1007/s10552-022-01567-w

Cited by 9 publications

(16 citation statements)

References 42 publications

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“…Table 2. Odds ratios (OR) and 95% confidence intervals (CI) of the association between portions of yoghurt intake per week and gastric cancer (GC), based on the study [21][22][23][24][25][26][27][28][29][31][32][33].…”

Section: Resultsmentioning

confidence: 99%

“…The current analysis is based on 16 studies with information on yoghurt intake, including two studies from Italy [20,21], one from Portugal [22], two from Spain [23,24], two from Greece [7,25], one from Finland [18], one from Japan [26], one from Russia [27], three from Mexico [28][29][30], two from the USA [31,32] and one from Brazil [33]. Of these, nine were hospital-based studies, and seven were population-based studies.…”

Section: Methodsmentioning

confidence: 99%

“…Notes: ATBC CPSG = The alphatocopherol beta carotene Cancer Prevention Study Group. Meta-analysis of the results for portions of yoghurt intake per week is continuous[17,18,[20][21][22][23][24][25][26][27][28][29][30][31][32][33].…”

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confidence: 99%

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Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium

et al. 2023

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Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94–1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88–0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85–0.99) and 0.78 (95% CI = 0.73–0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91–1.02) for cardia, 1.03 (95% CI = 1.00–1.07) for non-cardia, 1.12 (95% CI = 1.07–1.19) for diffuse and 1.02 (95% CI = 0.97–1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium

et al. 2023

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“…A previously validated FFQ (food frequency questionnaire) was used to assess dietary intake. 19 , 20 In addition, the method used to assess the presence of infection is considered the gold standard. 25 …”

Section: Discussionmentioning

confidence: 99%

“…A food frequency questionnaire (FFQ), validated in Brazilian populations with patients treated for colorectal cancer and patients from a case–control study of GAd, was administered during the interview. 19 , 20 The FFQ contained more than 120 food items, and each question was divided into three categories: (1) consumption frequency ranging from 1 to 10; (2) the unit of consumption (daily, weekly, monthly, or yearly); and (3) the size of the portion eaten (small, medium, or large) which were represented in grams or milliliters and their equivalents in home measures, for example teacups, cups, tablespoons, slices, among others. The responses were converted to food intake (grams per day or milliliters per day if applicable).…”

Section: Methodsmentioning

confidence: 99%

Dietary habits and Helicobacter pylori infection: is there an association?

Soares

Moraes

Ramos

et al. 2023

Therap Adv Gastroenterol

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Background: Helicobacter pylori ( H. pylori) is a group 1 carcinogen and the etiological agent of gastric diseases such as gastritis, ulcers, and gastric cancer. It infects approximately half of the world’s population. Risk factors associated with H. pylori infection include socioeconomic status, lifestyle, and diet. Objectives: This study aimed to evaluate the association between eating habits and H. pylori infection in patients from a reference hospital in Central Brazil. Design: This cross-sectional study included 156 patients from 2019 to 2022. Methods: Data were collected using a structured questionnaire on sociodemographic and lifestyle characteristics and a validated food frequency questionnaire. The H. pylori infection status (positive versus negative) was determined using the histopathological method. After grams/day, foods were stratified into tertiles of consumption (low, medium, and high). Simple and multiple binary logistic regression models were used in the analysis of odds ratios (ORs) and their respective 95% confidence intervals (CIs), with a 5% significance level. Results: The prevalence of H. pylori infection was 44.2% (69/156 patients). Infected individuals had a mean age of 49.6 ± 14.6 years; 40.6% were men, 34.8% were aged 60 years or older, 42.0% were unmarried, 7.2% had higher education, 72.5% were non-white, and 30.4% were obese. In the H. pylori-positive group, 55.1% were alcohol drinkers and 42.0% were smokers. The results of multiple analyses showed that the chance of H. pylori infection was higher among male participants (OR = 2.25; CI = 1.09–4.68) and individuals with obesity (OR = 2.68; CI = 1.10–6.51). Participants with moderate consumption of refined grains (bread, cookies, cakes, breakfast cereal) (OR = 2.41; CI = 1.04–5.62) and fruits (OR = 2.53; CI = 1.08–5.94) were more likely to be infected. Conclusion: In this study, male sex, obesity, and the consumption of refined grains and fruits were positively associated with H. pylori infection. Further research is needed to investigate this association and elucidate the underlying mechanisms.

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Association between the consumption of ultra-processed foods and the incidence of peptic ulcer disease in the SUN project: a Spanish prospective cohort study

Leone,

De la Fuente-Arrillaga,

Mas

et al. 2024

Eur J Nutr

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Purpose Consumption of ultra-processed foods (UPF) has increased despite potential adverse health effects. Recent studies showed an association between UPF consumption and some gastrointestinal disorders. We evaluated the association between UPF consumption and peptic ulcer disease (PUD) in a large Spanish cohort. Methods We conducted a prospective analysis of 18,066 participants in the SUN cohort, followed every two years. UPF was assessed at baseline and 10 years after. Cases of PUD were identified among participants reporting a physician-made diagnosis of PUD during follow-ups. Cases were only partially validated against medical records. Cox regression was used to assess the association between baseline UPF consumption and PUD risk. Based on previous findings and biological plausibility, socio-demographic and lifestyle variables, BMI, energy intake, Helicobacter pylori infection, gastrointestinal disorders, aspirin and analgesic use, and alcohol and coffee consumption were included as confounders.We fitted GEE with repeated dietary measurements at baseline and after 10 years of follow-up. Vanderweele’s proposed E value was calculated to assess the sensitivity of observed associations to uncontrolled confounding. Results During a median follow-up of 12.2 years, we recorded 322 new PUD cases (1.56 cases/1000 person-years). Participants in the highest baseline tertile of UPF consumption had an increased PUD risk compared to participants in the lowest tertile (HR = 1.52, 95% CI: 1.15, 2.00, Ptrend=0.002). The E-values for the point estimate supported the observed association. The OR using repeated measurements of UPF intake was 1.39 (95% CI: 1.03, 1.87) when comparing extreme tertiles. Conclusion The consumption of UPF is associated with an increased PUD risk.

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Consumption of processed and ultra-processed foods by patients with stomach adenocarcinoma: a multicentric case–control study in the Amazon and southeast regions of Brazil

Cited by 9 publications

References 42 publications

Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium

Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium

Dietary habits and Helicobacter pylori infection: is there an association?

Association between the consumption of ultra-processed foods and the incidence of peptic ulcer disease in the SUN project: a Spanish prospective cohort study

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