Consumption of polyunsaturated fatty acids and risk of incident psoriasis and psoriatic arthritis from the Nurses’ Health Study II

Park, M. K.; Li, W.; Paek, So Yeon; Li, Xin; Wu, Shaowei; Li, T.; Qureshi, Abrar A.; Cho, Eunyoung

doi:10.1111/bjd.15059

Cited by 4 publications

(2 citation statements)

References 16 publications

(17 reference statements)

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“…In our study, the concurrent reduction of SFA levels and enrichment of omega-3 PUFAs in our mouse model significantly reduced the severity of initial psoriasiform inflammation. There is a controversial discussion on the impact and efficacy of PUFA supplementation as a therapeutic measure in inflammatory disorders such as psoriasis (Mari et al, 2017;Mayser et al, 2002;Park et al, 2017;Qin et al, 2014;Teng et al, 2014). Our data indicate that a dietary reduction of SFA alone-without PUFA supplementation-was sufficient to improve psoriasiform inflammation in obese mice independent of weight loss, which was not shown before.…”

Section: Discussionsupporting

confidence: 38%

High-Fat Diet Exacerbates Early Psoriatic Skin Inflammation Independent of Obesity: Saturated Fatty Acids as Key Players

Herbert

Franz

Popkova

et al. 2018

Journal of Investigative Dermatology

118

126

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In obesity, hypertrophic adipocytes secrete high amounts of adipocytokines, resulting in low-grade inflammation amplified by infiltrating proinflammatory macrophages, oxidative stress, hypoxia, and lipolysis. These chronic proinflammatory conditions support the development of type II diabetes and cardiovascular diseases, but the mechanisms of obesity-related exacerbation of inflammatory skin disorders like psoriasis are unclear. In this study, we uncovered dietary saturated fatty acids (SFAs) as major risk factors for the amplification of skin inflammation, independent of obesity-related parameters such as fat mass extension, adipocytokine levels, and glucose homeostasis. Correlation analyses in a cohort of psoriasis vulgaris patients showed that free fatty acid serum level was the only obesity-associated parameter affecting disease severity. Studies in mice with high-fat diet-induced obesity with psoriasiform inflammation confirmed this critical role of free fatty acids. An increase of free fatty acids in healthy, lean mice alone was sufficient to induce an exacerbation of psoriasiform inflammation. In particular, saturated fatty acids sensitize myeloid cells to an increased inflammatory response in answer to proinflammatory stimuli, which in turn augments the activation of keratinocytes. Consequently, reduction of nutritional saturated fatty acids alone diminished the psoriatic phenotype in obese mice. Thus, our findings may open new perspectives for adjuvant dietary measures accompanying anti-inflammatory psoriasis therapies in lean and obese patients.

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Section: Discussionsupporting

confidence: 38%

High-Fat Diet Exacerbates Early Psoriatic Skin Inflammation Independent of Obesity: Saturated Fatty Acids as Key Players

Herbert

Franz

Popkova

et al. 2018

Journal of Investigative Dermatology

118

126

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show abstract

“…However, patients taking omega-3 acid supplements revealed a statistically significant reduction in taking NSAID and acetaminophen when compared with patients taking olive oil. Decreased concentration of leukotriene B4, which is produced by leukocytes during the inflammatory process, was the statistically significant change observed within the group treated with omega-3 acids [40], whereas significant consumption of omega-6 acids and linolenic acid (LA) reduced the risk of developing PsA, and not psoriasis [41].…”

Section: General Characteristics Of Omega-3 and Omega-6 Acids And Thmentioning

confidence: 97%

The place of omega-3 and omega-6 acids in supplementary treatment of inflammatory joint diseases

Kwiatkowska

Maślińska

2020

Reumatologia

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Eating habits have been analysed for years as a factor influencing the development of autoimmune diseases and susceptibility to infections. On the basis of research, observational studies and metaanalyses, special attention was paid to omega-3 and omega-6 acids. The purpose of the review is to show the importance of omega-3 and omega-6 acids as important ingredients in the healthy diet and as factors protecting against the development of the most common inflammatory rheumatic diseases. The influence of these omega-3 and-6 acids on the course of rheumatic diseases and arguments for their use as complementary therapy are also presented.

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Nutrition and psoriasis

Muzumdar

Rothe

2022

Clinics in Dermatology

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Consumption of polyunsaturated fatty acids and risk of incident psoriasis and psoriatic arthritis from the Nurses’ Health Study II

Cited by 4 publications

References 16 publications

High-Fat Diet Exacerbates Early Psoriatic Skin Inflammation Independent of Obesity: Saturated Fatty Acids as Key Players

High-Fat Diet Exacerbates Early Psoriatic Skin Inflammation Independent of Obesity: Saturated Fatty Acids as Key Players

The place of omega-3 and omega-6 acids in supplementary treatment of inflammatory joint diseases

Nutrition and psoriasis

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