Consumption of Oxidized and Partially Hydrogenated Oils Differentially Induces Trans-Fatty Acids Incorporation in Rats' Heart and Dyslipidemia

Dhibi, Madiha; Mnari, Amira; Brahmi, Faten; Houas, Zohra; Chargui, Issam; Kharroubi, Wafa; Hammami, Mohamed

doi:10.1080/07315724.2014.938183

Cited by 5 publications

(4 citation statements)

References 44 publications

(46 reference statements)

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“…The obtained results came in agreement with Aronis et al [40]who suggested that an improvement of lipid metabolism disorders and also worst in insulin resistance in TFAs and HFD groups suffered from obesity. Lp (a) level was markedly increased in the trans group and this result was in agreement with Dhibi et al [41]. They reported the inflammatory impacts and endothelial dysfunction after PHVO consumption which has been shown to induce accumulation of inflammatory cells, linked with increased activity of Lp (a), inducing cardiovascular risk and atherosclerotic.…”

Section: Discussionsupporting

confidence: 89%

Effects of trans-Fatty Acid on Lipoproteins-a, Oxidative Status and Expression of Leptin and Leptin Receptor Genes in Albino Rats

yasmin

El-Dawy

Abdel-Fattah

et al. 2021

Zagazig Veterinary Journal

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High consumption of trans-fatty acids (TFAs) linked with obesity, disorders of lipoproteins, type 2 Diabetes Mellitus (T2DM), risk factors of coronary heart disease, and development of atherosclerosis. The intent of our trials was to assess the possible bad impact of TFAs on the lipid status and focusing on characterizing the physiological alters in an animal model comparing with cis fatty acids. Sixty male albino rats, with nearly similar average weight 170±5wereassignedinto 4 main groups (15 rats per group) and kept on a standard diet set for 12 weeks. All groups received different diet treatment for successive 12 weeks. Group A: control group received a conventional diet, group B received a diet contained 360 gm TFAs inform of partially hydrogenated vegetable oil (PHVO) l kg of diet, group C was fed a High Fat Diet (HFD) contained 360 gm beef tallow l kg of diet for, and group D received a diet containing 360 gm linseed oil l kg of diet. Both feeding of TFAs and HFD resulted in a marked increase in the body weight in reach to the obesity grade with a significant increase (P≤0.05) in leptin and leptin receptor gene expression. Also, a significant increase in Malondialdehyde (MDA) and Lipoprotein-a (Lp-a) and a marked decrease in total antioxidant capacity (TAC). It could be concluded that TFAs induce combined increased body weight, with imbalance in oxidative stress, dyslipidemia, and elevated atherogenic Lipoprotein-a may be leading to development of atherosclerosis and coronary heart disease.

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Section: Discussionsupporting

confidence: 89%

Effects of trans-Fatty Acid on Lipoproteins-a, Oxidative Status and Expression of Leptin and Leptin Receptor Genes in Albino Rats

yasmin

El-Dawy

Abdel-Fattah

et al. 2021

Zagazig Veterinary Journal

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“…The high intake of TFA in rats fed HVF diet was re ected in the increased TFA deposition in the tissues as also reported by Dhibi et al, 48 and in the occurrence of histological atherosclerotic lesions. In this context, HVF diet caused an increase of pro-in ammatory serum cytokines IL-1β and TNF-α cytokines.…”

Section: Discussionsupporting

confidence: 79%

Metabolic parameters and gut microbiota composition of rats fed high-fat diets based on ruminant fat compared with hydrogenated vegetable fat

Lb¹,

Spa²,

Bessa³

et al. 2021

Preprint

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This study tested the hypothesis that naturally and industrially produced trans fatty acids (TFA) exert distinct effects on rats’ metabolic parameters. Wistar rat groups were fed the diets: CONT - without added fat; HVF − 20% hydrogenated vegetable fat (HVF); and RUM − 20% ruminant fat. Biochemical markers, cytokine levels, fatty acid (FA) composition of liver, heart and adipose tissue, liver histology and the gut microbial composition were also evaluated. Rats fed RUM presented lower deposition of adipose tissue and LDL and higher HDL and anti-inflammatory IL-10 than those fed CONT and HVF. Pro-inflammatory cytokines, malondialdehyde (MDA) and aspartate aminotransferase (AST) were higher in group HVF than CONT and RUM. In all types of tissue, the highest TFA levels were observed in rats fed HVF, which contributed to the development of fatty liver. The RUM diet led to higher concentrations of stearic acid and conjugated linoleic acid (CLA). The lower incorporation of TFA and distinct FA profile in the liver of rats fed RUM compared to HVF could be associated with protection hepatic. The microbial gut communities were significantly dissimilar among the groups. It is plausible that ruminant fat might reduce risk parameters involved in the development of cardiovascular disease.

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“…Dietary intake of TFA was translated directly into an increased TFA concentration in the liver, heart and adipose tissue, as also reported by Dhibi et al 54 . The lower accumulation of adipose tissue in the HVF group suggests that our research procedures may have predisposed the rats to the onset of non-alcoholic fatty liver disease (NAFLD), as confirmed by the histopathologic analysis of hepatic tissue.…”

Section: Discussionsupporting

confidence: 74%

Ruminant fat intake improves gut microbiota, serum inflammatory parameter and fatty acid profile in tissues of Wistar rats

Medeiros

Alves

Bessa

et al. 2021

Sci Rep

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This study tested the hypothesis that naturally and industrially produced trans-fatty acids can exert distinct effects on metabolic parameters and on gut microbiota of rats. Wistar rats were randomized into three groups according to the diet: CONT-control, with 5% soybean oil and normal amount of fat; HVF-20% of hydrogenated vegetable fat (industrial); and RUM-20% of ruminant fat (natural). After 53 days of treatment, serum biochemical markers, fatty acid composition of liver, heart and adipose tissue, histology and hepatic oxidative parameters, as well as gut microbiota composition were evaluated. HVF diet intake reduced triglycerides (≈ 39.39%) and VLDL levels (≈ 39.49%). Trans-fatty acids levels in all tissue were higher in HVF group. However, RUM diet intake elevated amounts of anti-inflammatory cytokine IL-10 (≈ 14.7%) compared to CONT, but not to HVF. Furthermore, RUM intake led to higher concentrations of stearic acid and conjugated linoleic acid in all tissue; this particular diet was associated with a hepatoprotective effect. The microbial gut communities were significantly different among the groups. Our results show that ruminant fat reversed the hepatic steatosis normally caused by high fat diets, which may be related to the remodelling of the gut microbiota and its anti-inflammatory potential.

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Consumption of Oxidized and Partially Hydrogenated Oils Differentially Induces Trans-Fatty Acids Incorporation in Rats' Heart and Dyslipidemia

Abstract: In conclusion, process-induced TFAs cause changes including proatherogenic plasma lipid markers, heart fatty acid profiles, and coronary artery histology depending on the TFA level in the supplemented fat and therefore on the type of technological process used.

Cited by 5 publications

References 44 publications

Effects of trans-Fatty Acid on Lipoproteins-a, Oxidative Status and Expression of Leptin and Leptin Receptor Genes in Albino Rats

Effects of trans-Fatty Acid on Lipoproteins-a, Oxidative Status and Expression of Leptin and Leptin Receptor Genes in Albino Rats

Metabolic parameters and gut microbiota composition of rats fed high-fat diets based on ruminant fat compared with hydrogenated vegetable fat

Ruminant fat intake improves gut microbiota, serum inflammatory parameter and fatty acid profile in tissues of Wistar rats

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