Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, and Apolipoprotein-B in Young Men and Women

Stanhope, Kimber L.; Bremer, Andrew A.; Medici, Valentina; Nakajima, Katsuyuki; Ito, Yasuki; Nakano, Takamitsu; Chen, Guoxia; Fong, Tak; Lee, Vivien; Menorca, Roseanne I.; Keim, Nancy L.; Havel, Peter J.

doi:10.1210/jc.2011-1251

Cited by 265 publications

(183 citation statements)

References 38 publications

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“…We also take above concerns into account, the hematology results were in normal range in adult monkeys [63]. Several articles report that triglycerides level were increased as the consequences of ingesting sugar-sweetened beverage [30][31][32]61], in our study, triglycerides level increased significantly after 1 year of beverage intake. Studies indicate that fructose consumption and have been associated with fatty liver [64,65] and hepatic fibrosis [66] in people, higher exposures to dietary fructose result in the development of hepatic lipidosis in nonhuman primates when consumed ad libitum for periods equivalent to ≥ 1 human year and ALT, AST, GGT increased after 6 weeks of high fructose diet exposure [67], the detected biomarkers (NEFA, TCHO, ALT, AST, GGT in Tables 3 and 4) changing trend in our study also reveal this possibility.…”

Section: Discussionsupporting

confidence: 58%

“…Recently several articles report that the consumption of fructose sweetened beverages increases visceral adipose deposition and triglycerides levels [30,31], produces dyslipidemia, and decreases glucose tolerance/insulin sensitivity [32]. HFCS made by enzymatic isomerization of glucose to fructose was introduced as HFCS-42 (42% fructose) and HFCS-55 (55% fructose) in 1967 and 1977, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Fructose-Fed Induced Metabolic Syndrome Model in Cynomolgus Monkeys

Ding¹,

Zhang²,

Zhang³

et al. 2017

J Vet Sci Technol

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The incidences of obese and metabolic syndrome have risen dramatically in recent decades. The pathological conditions of metabolic syndrome greatly increase the risk factors of cardiovascular disease, type 2 diabetes and NASH. The over consumption of high-fructose in beverage has been considered may play a role in the causes. To better understand the association of excessive fructose intake and pathophysiological progressing for obesity, type 2 diabetes and NASH, we assessed anthropometrics and metabolic parameters in a total of 71 cynomolgus monkeys after the consumption of high fructose diet within a 12 months period, including but not limited to body weight, body fat, HbA1C, liver enzymes. All the assessment values showed as Mean ± SD, and have compared from baseline of pre-feeding of high fructose diet to the 12 months of post feeding. The result showed that about 13% monkeys were overt T2DM, 32% monkeys became obese with an impaired IVGTT profile and 31% monkeys obesity animals at last, many features of the metabolic syndrome such glucose and insulin impairment were existed in related cohorts. We demonstrated that dietary of high fructose induced metabolic syndrome in cynomolgus monkeys that provides a good translational animal model system to investigate obesity and metabolic syndrome pathogenesis, prevention and treatment.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Fructose-Fed Induced Metabolic Syndrome Model in Cynomolgus Monkeys

Ding¹,

Zhang²,

Zhang³

et al. 2017

J Vet Sci Technol

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“…The higher carbohydrate diet employed in the Women's Health Initiative had no effect on either triglycerides or high density lipoprotein [42]. Some investigators have suggested that added sugars may increase abnormalities by raising low density lipoprotein (LDL) [43] [44], although research in our laboratory has yielded no change in either LDL or total cholesterol [34] [45].…”

Section: Discussionmentioning

confidence: 87%

High Fructose Corn Syrup and Sucrose Sweetened Milk Improve Dietary Quality during Weight Loss by Displacing Energy Dense, Nutrient Poor Foods

Sinnett¹,

Lowndes²,

Nguyen³

et al. 2014

FNS

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We examined dietary quality and weight loss among adults who drank flavored milk sweetened with either high fructose corn syrup (HFCS) or sucrose at average population consumption levels of fructose. This was a blinded, prospective randomized controlled trial evaluating the effects of 10% or 20% of calories from either HFCS or sucrose sweetened 1% fat, flavored milk as part of a hypocaloric diet. Participants (n = 98) followed this diet and completed three day food records at the beginning and end of the intervention. Results were pooled and compared with 31 non-milk drinking controls. Equivalent and significant weight loss occurred in all intervention groups whose data were pooled. Weight loss was different between the groups (weight loss and sweetened milk: pre: 192 ± 28 versus post: 183 ± 28 pounds; control: pre: 190 ± 22 versus post: 187 ± 22 pounds, interaction p < 0.001). Compliance to milk consumption was over 96%. The increase in percentage of calories from carbohydrates (49 ± 8 versus 55 ± 6, p < 0.001) and protein (17 ± 5 versus 21 ± 3, p < 0.001) was offset by a reduction in percentage of calories from fat (33 ± 7 versus 24 ± 5, p < 0.001). Intakes of dietary calcium (839 ± 377 versus 1530 ± 407 milligrams, p<0.001), vitamin D (4 ± 3 versus 13 ± 3 micrograms, p < 0.001), potassium (2417 ± 766 versus 3183 ± 667 milligrams, p < 0.001) and magnesium (272 ± 83 versus 306 ± 73 milligrams, p = 0.001) increased, while sodium (3216 ± 1161 versus 2253 ± 684 milligrams, p < 0.001) declined. We conclude that HFCS and sucrose consumed at 10% -20% of calories may improve dietary quality during weight loss by improving compliance with nutrient dense foods such as low fat flavored milk.

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“…However, HFCS intake may promote the development of chronic diseases, such as diabetes and cardiovascular disease 11 , which have been related to hypertriglyceridemia 12 and insulin resistance 13 in patients with prolonged HFCS intake.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary high fructose corn syrup on regulation of energy intake and leptin gene expression in rats

et al. 2015

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OBJECTIVE: To evaluate in Wistar rats the effect of chronic use of high fructose corn syrup on serum lipids, body weight, energy intake regulation, and expression of associated genes. METHODS: For 11 weeks, male rats were fed a standard diet with either water (control) or 15% high fructose corn syrup solution, or fed a high-fat diet. The rats' food intake and body weight were measured weekly. Expression of leptin and fatty acid synthase genes was quantified in their brain and adipose tissue upon sacrifice at age 119 days using real-time polymerase chain reaction. RESULTS: The intake of 15% high fructose corn syrup did not affect the rats' weight, only the rats on the high-fat diet gained significant weight. The rats in both diets had lower levels of leptin expression and high levels of fatty acid synthase in the brain, which were associated with high serum triglycerides. CONCLUSION: Fifteen percent high fructose corn syrup intake and the high-fat diet reduced leptin gene expression in the brain of Wistar rats, with differential effects on weight gain.

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Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, and Apolipoprotein-B in Young Men and Women

Abstract: Consumption of HFCS-sweetened beverages for 2 wk at 25% E increased risk factors for cardiovascular disease comparably with fructose and more than glucose in young adults.

Cited by 265 publications

References 38 publications

Fructose-Fed Induced Metabolic Syndrome Model in Cynomolgus Monkeys

Fructose-Fed Induced Metabolic Syndrome Model in Cynomolgus Monkeys

High Fructose Corn Syrup and Sucrose Sweetened Milk Improve Dietary Quality during Weight Loss by Displacing Energy Dense, Nutrient Poor Foods

Effects of dietary high fructose corn syrup on regulation of energy intake and leptin gene expression in rats

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