Consumption of fried foods and weight gain in a Mediterranean cohort: The SUN project

Sayón-Orea, Carmen; Bes–Rastrollo, Maira; Basterra-Gortari, Francisco Javier; Beunza, Juan J.; Guallar-Castillón, Pilar; Fuente-Arrillaga, Carmen de la; Martínez‐González, Miguel Ángel

doi:10.1016/j.numecd.2011.03.014

Cited by 74 publications

(75 citation statements)

References 23 publications

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“…Some strengths of the SUN cohort deserve to be mentioned: the homogeneity of participants with regard to socio-economic status, which helps to better control confounding and the higher educational level of participants in the cohort that ensures a higher validity in self-reported information (Beunza et al 2010;Sayon-Orea et al 2011). A potential limitation in our study is the self-reported outcome; nevertheless, self-reported weight and BMI had been previously validated (Bes-Rastrollo et al 2005).…”

Section: Discussionmentioning

confidence: 97%

Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project

et al. 2012

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Genetic factors may interact with lifestyle factors to modify obesity risk. FTO and PPARG2 are relevant obesogenes. Our aim was to explore the effect of Pro12Ala (rs1801282) of PPARG2 and rs9939609 of FTO on obesity risk and to examine their interaction with lifestyle factors in an elderly population. Subjects (n = 978; aged 69 ± 6) were recruited from the SUN (Seguimiento Universidad de Navarra) Project. DNA was obtained from saliva, and lifestyle and dietary data were collected by validated self-reported questionnaires. Genotyping was assessed by RT-PCR plus allele discrimination. Subjects carrying the Ala allele of PPARG2 gene had a significantly increased obesity risk compared to non-carrier (Pro12Pro) subjects (OR, 1.66; 95 % CI, 1.01-2.74; p = 0.045). Greater obesity risk was also found in inactive or high carbohydrate intake subjects with the Ala12 allele of PPARG2 gene. Interestingly, subjects carrying the Ala allele of the PPARG2 gene and with a high CHO ([246 g/ day) intake had an increased obesity risk compared to Pro12Pro subjects (OR, 2.67; 95 % CI, 1.3-5.46; p = 0.007; p for [CHO 9 PPARG2] interaction = 0.046). Moreover, in subjects with a high CHO intake, the co-presence of the Ala allele of PPARG2 gene and one minor A allele (rs9939609) of FTO gene did increase obesity risk (OR, 3.26; 95 % CI,; p = 0.021) when compared to non-carrier (Pro12Pro/TT) subjects. In conclusion, it appears that lifestyle factors may act as effect modifiers for obesity risk linked to Ala12 allele of the PPARG2 gene and the minor A allele of FTO gene in an elderly population.

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Section: Discussionmentioning

confidence: 97%

Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project

et al. 2012

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“…There is evidence, although still limited, indicating that frequent fried food consumption is associated with increased risk of obesity and type 2 diabetes among non-pregnant individuals. During a median of 6.1 years of follow-up in the SUN project (a Mediterranean cohort), participants who consumed fried foods more than four times/week had a 37% higher risk of being overweight and developing obesity in comparison with those who consumed fried foods less than twice/week [7]. Similarly, fried food consumption was also positively associated with general and central obesity in a cross-sectional analysis in another Mediterranean cohort [6].…”

Section: Discussionmentioning

confidence: 99%

“…Frying also makes food crunchy and aromatic and improves food palatability, which may in turn lead to excess intake [6]. Recently, frequent consumption of fried foods has been linked to a higher risk of being overweight and obesity in two Mediterranean cohorts [6, 7]. However, there are few prospective epidemiological studies examining the association of fried food consumption with other health outcomes.…”

Section: Introductionmentioning

confidence: 99%

Pre-pregnancy fried food consumption and the risk of gestational diabetes mellitus: a prospective cohort study

et al. 2014

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Aims/hypothesis Fried foods are frequently consumed in Western countries. However, the health effects of frequent fried food consumption in humans are not well understood. We aimed to prospectively examine the association between pre-pregnancy fried food consumption and risk of incident gestational diabetes mellitus (GDM). Methods We included 21,079 singleton pregnancies from 15,027 women in the Nurses’ Health Study II cohort. Since 1991 and every 4 years thereafter, we collected diet information, including consumption of fried foods at home and away from home, using a validated food frequency questionnaire. We used generalised estimating equations with log-binomial models to estimate the RRs and 95% CIs. Results We documented 847 incident GDM pregnancies during 10 years of follow-up. After adjustment for age, parity, dietary and non-dietary factors, the RRs (95% CIs) of GDM among women who consumed total fried foods 1–3, 4–6 and ≥ 7 times/week, compared with those who consumed it less than once/week, were 1.13 (0.97, 1.32), 1.31 (1.08, 1.59) and 2.18 (1.53, 3.09), respectively (p for trend < 0.001). The association persisted after further adjustment for BMI (p for trend = 0.01). When analysed separately, we found a significant association of GDM with fried food consumption away from home, but not with fried food consumption at home. Conclusions/interpretation Frequent fried food consumption, particularly away from home, was significantly associated with a greater risk of incident GDM. Our study indicates potential benefits of limiting fried food consumption in the prevention of GDM in women of reproductive age.

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“…Repeated use of this oil has become a common practice due to low level of awareness among the public about the bad effect of this practice [9]. Nowadays, the consumption of deep-fried food has gained popularity which may cause increased risk of obesity [24].…”

Section: Discussionmentioning

confidence: 99%

Repeatedly Heated Vegetable Oils and Lipid Peroxidation

Jaarin¹,

Kamisah²

2012

Lipid Peroxidation

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Consumption of fried foods and weight gain in a Mediterranean cohort: The SUN project

Cited by 74 publications

References 23 publications

Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project

Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project

Pre-pregnancy fried food consumption and the risk of gestational diabetes mellitus: a prospective cohort study

Repeatedly Heated Vegetable Oils and Lipid Peroxidation

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