Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

Morris, Marthac Clare; Evans, Denis A.; Bienias, Julia L.; Tangney, Christine C.; Bennett, David A.; Wilson, Robert S.; Aggarwal, Neelum T.; Schneider, Julie A.

doi:10.1001/archneur.60.7.940

Cited by 939 publications

(622 citation statements)

References 60 publications

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“…One of the first such studies showed that people who ate fish at least once a week had a 60% lower risk of developing AD [130] and a slower rate of cognitive decline [131]. The relationship between fat intake (both saturated and trans-unsaturated fat) and cognitive decline also appears to be linear [132], and a high intake of copper with a diet abundant in saturated and trans fats may predict an increased rate of cognitive decline [133].…”

Section: Epidemiologic Studiesmentioning

confidence: 99%

“…The relationship between fat intake (both saturated and trans-unsaturated fat) and cognitive decline also appears to be linear [132], and a high intake of copper with a diet abundant in saturated and trans fats may predict an increased rate of cognitive decline [133]. By contrast, total intake of n-3 polyunsaturated fatty acids may be associated with a reduced risk of AD [130]. These findings are congruent with data from animal models showing that fat intake may be related not only to vascular risks but also to a direct effect of polyunsaturated fatty acids on Aβ accumulation [134].…”

Section: Epidemiologic Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Sonnen¹,

Breitner²,

Lovell³

et al. 2008

Free Radical Biology and Medicine

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Section: Epidemiologic Studiesmentioning

confidence: 99%

Section: Epidemiologic Studiesmentioning

confidence: 99%

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Sonnen¹,

Breitner²,

Lovell³

et al. 2008

Free Radical Biology and Medicine

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“…DHA is an omega-3 polyunsaturated fatty acid found in membrane phospholipids and a deficiency in this fatty acid may play a role in Alzheimer's disease. A low intake of fish (Morris et al 2003), the major dietary source of DHA, and low serum DHA levels (Kyle et al 1999) are both linked to an increase in likelihood of developing Alzheimer's disease, whereas a high intake of fish is related to a decreased risk (Morris et al 2003). Similarly, Alzheimer's patients and humans with mild cognitive impairment have lower plasma levels of DHA and a larger n-6/n-3 fatty acid ratio (Conquer et al 2000).…”

Section: Proprietary Blend Of Docosahexaenoic Acid and Phospholipidsmentioning

confidence: 99%

Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging

Araujo

Studzinski

Head

et al. 2005

AGE

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The present review focuses on the utility of a canine model in evaluating nutritional interventions for age-related cognitive dysfunction. Aged dogs demonstrate progressive cognitive decline with concurrent amyloid-beta pathology that parallels the pathology observed in aging humans. Dogs, therefore, provide a natural model of human pathological aging. We have and are in the process of evaluating several nutritional-based interventions aimed at preventing cognitive decline and brain aging. In a three-year longitudinal study, we examined the effects of a diet enriched with antioxidants and mitochondrial cofactors on several measures of cognition and brain aging. Compared to controls, aged dogs on the enriched diet demonstrated both short-and long-term cognitive benefits, as well decreased deposition of amyloid-beta protein. The diet also reduced behavioral signs associated with canine Cognitive Dysfunction Syndrome when assessed in veterinary clinical trials. We also have preliminary evidence suggesting a beneficial effect of a proprietary blend of docosahexaenoic acid and phospholipids on both cognitive and physiological measures. Collectively, our data indicate (1) that the dog, either in the laboratory or in the clinic, provides an important tool for assessing nutritional interventions and (2) that combination interventions aimed at several mechanisms of pathological aging may prove more effective than single nutritive components in human trials.

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“…Whereas we studied a population of women who were between the ages of 27 and 44 at the outset, the Health Professionals study followed a population of men ages 44-79 at the outset. Furthermore, EPA and DHA have additional benefit among persons with chronic diseases, [40,41] which are more prevalent in the Health Professionals Follow-Up Study. Therefore, any immunosuppressive risk from high EPA and DHA intake in the elderly may have been balanced by the fatty acids' benefit in chronic disease yielding no association in the Health Professionals Follow-Up Study.…”

Section: Discussionmentioning

confidence: 99%

Fatty acid intake and the risk of community-acquired pneumonia in U.S. women

Alperovich¹,

Neuman

Willett

et al. 2007

Nutrition

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Objective-Despite substantial progress in the treatment of community-acquired pneumonia, there are limited data on dietary risk factors. Fatty acid intake may influence community-acquired pneumonia risk by modulating the immune system. Our study prospectively examined the association between fatty acid intake and community-acquired pneumonia risk.Research Methods & Procedures-The study population included 83,165 women from the Nurses' Health Study II cohort who were between the ages of 27 and 44 in 1991. The women reported lifestyle habits on biennial questionnaires and dietary intake every four years by validated semiquantitative food frequency questionnaires (FFQ). There were 925 pneumonia cases over 10 years of follow-up. We examined independent associations for six fatty acids using Cox proportional hazards regression.Results-Women in the highest quintile of palmitic acid intake had a 54% greater risk of pneumonia compared to the lowest quintile: multivariate relative risk (RR)=1.54; 95% confidence interval (CI): 1.12, 2.12; p for trend = 0.002. Oleic acid intake was inversely associated with pneumonia risk (highest quintile multivariate RR=0.75; 95% CI: 0.55, 1.04; p for trend = 0.02). Women in the highest quintile of docosahexanoic acid (DHA) and eicosapentanoic acid (EPA) intake had a 24% greater risk of community-acquired pneumonia than the lowest quintile (multivariate RR=1.24; 95% CI: 1.00, 1.55; p for trend = 0.08). No significant associations were found for linoleic acid, alpha-linolenic acid, or DHA alone.Conclusions-Fatty acid intake may affect the risk of community-acquired pneumonia in young and middle-aged women. Higher dietary intake of palmitic acid and possibly DHA and EPA may increase the risk of community-acquired pneumonia in women while higher oleic acid intake may decrease the risk.

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Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

Abstract: Dietary intake of n-3 fatty acids and weekly consumption of fish may reduce the risk of incident Alzheimer disease.

Cited by 939 publications

References 60 publications

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging

Fatty acid intake and the risk of community-acquired pneumonia in U.S. women

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