Consumption of different soymilk formulations differentially affects the gut microbiomes of overweight and obese men

Fernandez-Raudales, Dina; Hoeflinger, Jennifer L.; Bringe, Neal A.; Cox, Stephen B.; Dowd, Scot E.; Miller, Michael J.; Mejía, Elvira González de

doi:10.4161/gmic.21578

Cited by 63 publications

(74 citation statements)

References 47 publications

(49 reference statements)

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“…For instance, the Prevotella enterotype is known to be sensitive to diet changes and is linked to a high carbohydrate/fiber diet in humans ( De Filippo et al, 2010 ; Liu et al, 2012 ; Willing et al, 2010 ; Wu et al, 2011 ). In both mouse ( Neyrinck et al, 2011 ) and human ( Fernandez-Raudales et al, 2012 ; Wu et al, 2011 ) gut microbiota studies, the abundance of Prevotella was found to change upon dietary intervention. Furthermore, Wang et al have shown that hosting wild mice in a laboratory environment on chow diet causes a shift in enterotypes, from the original Bacteroides -dominated (with microbial metabolism more dedicated to protein degradation) to the Robinsoneilla -dominated (more dedicated to carbohydrate degradation) enterotype ( Wang et al, 2014 ).…”

Section: Practical Issues Influence the Composition Of Human And Murimentioning

confidence: 99%

How informative is the mouse for human gut microbiota research?

Nguyen

Vieira-Silva

Liston

et al. 2015

Disease Models &Amp; Mechanisms

1,014

875

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The microbiota of the human gut is gaining broad attention owing to its association with a wide range of diseases, ranging from metabolic disorders (e.g. obesity and type 2 diabetes) to autoimmune diseases (such as inflammatory bowel disease and type 1 diabetes), cancer and even neurodevelopmental disorders (e.g. autism). Having been increasingly used in biomedical research, mice have become the model of choice for most studies in this emerging field. Mouse models allow perturbations in gut microbiota to be studied in a controlled experimental setup, and thus help in assessing causality of the complex host-microbiota interactions and in developing mechanistic hypotheses. However, pitfalls should be considered when translating gut microbiome research results from mouse models to humans. In this Special Article, we discuss the intrinsic similarities and differences that exist between the two systems, and compare the human and murine core gut microbiota based on a meta-analysis of currently available datasets. Finally, we discuss the external factors that influence the capability of mouse models to recapitulate the gut microbiota shifts associated with human diseases, and investigate which alternative model systems exist for gut microbiota research.

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Section: Practical Issues Influence the Composition Of Human And Murimentioning

confidence: 99%

How informative is the mouse for human gut microbiota research?

Nguyen

Vieira-Silva

Liston

et al. 2015

Disease Models &Amp; Mechanisms

1,014

875

View full text Add to dashboard Cite

show abstract

“…41 Soymilk intake in newborns was found to slightly enlarge the number of Bifidobacterium species in the infants. 42 Nevertheless, neither analyzed the isoflavone content of the soymilk or soy formula milk used; therefore, the slight modifications observed could not be attributed to specific components of the milk.…”

Section: Soy Productsmentioning

confidence: 99%

Impact of Polyphenols and Polyphenol-Rich Dietary Sources on Gut Microbiota Composition

Etxeberría

Fernández‐Quintela

Milagro³

et al. 2013

J. Agric. Food Chem.

319

232

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Gut microbiota plays a key role in host physiology and metabolism. Indeed, the relevance of a well-balanced gut microbiota composition to an individual´s health status is essential for the person's well-being. Currently, investigations are focused on analyzing the effects of pre-and probiotics as new therapeutic tools to counteract the disruption of intestinal bacterial balance occurring in several diseases. Polyphenols exert a wide range of beneficial health effects. However, although specific attention has been paid in recent years to the function of this "biological entity" in the metabolism of polyphenols, less is known about the modulatory capacity of these bioactive compounds on gut microbiota composition. This review provides an overview of the latest investigations carried out with pure polyphenols, extracts rich in polyphenols and polyphenol-rich dietary sources (such as cocoa, tea, wine, soy products and fruits), and critically discusses the consequences to gut microbiota composition which are produced.

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“…It will also be important to avoid deleterious changes in lipid profiles that are not associated with major changes in body weight or the disappearance of long-term benefits. Furthermore, there are essential differences between the rodents and humans; for example, probiotics found in humans may modulate the absorption and bioavailability of soybeans products and metabolize active compounds into inactive ones, and vice versa [99,100]. Moreover, how cellular metabolism regulates drug absorption in different ethnic groups is also unclear.…”

Section: Conclusion and Future Research Perspectivesmentioning

confidence: 98%