Consumption of dairy products and odds of breast cancer: an Iranian case–control study

Dashti, Fatemeh; Soltani, Sanaz; Benisi-Kohansal, Sanaz; Azadbakht, Leila; Esmaillzadeh, Ahmad

doi:10.1007/s12282-021-01317-x

Cited by 2 publications

(1 citation statement)

References 34 publications

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“… 28 Also, we have previously found an inverse association between low-fat dairy and breast cancer. 29 Generally, major sources of LA include vegetable oils, seeds, nuts, meats, and eggs. However, it is the predominant PUFA in other foods with low fat content, such as low-fat dairy, vegetables, fruits, and grains.…”

Section: Discussionmentioning

confidence: 99%

Dietary linoleic acid intake in relation to breast cancer: A case-control study

Joya,

Naghshi,

Sadeghi

et al. 2023

Health Promot Perspect

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Background: The present study aimed to investigate the association between dietary linoleic acid (LA) intake and breast cancer in women. Methods: In this population-based case-control study, we enrolled 350 pathologically confirmed breast cancer cases and 700 controls which were matched with cases in terms of age and socioeconomic status. Dietary intakes were assessed using a 106-item Willett-format semi-quantitative dish-based food frequency questionnaire (DS-FFQ). Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated. Results: A significant inverse association was found between LA intake and odds of breast cancer (OR: 0.41, 95% CI: 0.30-0.56). After adjusting for potential confounders, women in the highest tertile of dietary LA intake were 48% less likely to have breast cancer compared with those in the lowest tertile (OR: 0.52, 95% CI: 0.28-0.95). Such a significant inverse association was also seen among normal-weight women (OR: 0.29, 95% CI: 0.14-0.63), and premenopausal women (OR: 0.15, 95% CI: 0.02-0.95). Conclusion: The findings of current study provide evidence for a protective role of LA against breast cancer particularly among normal-weight and premenopausal women. Prospective studies are needed to confirm this association.

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Section: Discussionmentioning

confidence: 99%

Dietary linoleic acid intake in relation to breast cancer: A case-control study

Joya,

Naghshi,

Sadeghi

et al. 2023

Health Promot Perspect

Self Cite

View full text Add to dashboard Cite

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The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression

et al. 2023

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Purpose of Review This review evaluates cow milk’s impact on breast carcinogenesis by linking recent epidemiological evidence and new insights into the molecular signaling of milk and its constituents in breast cancer (BCa) pathogenesis. Recent Findings Recent prospective cohort studies support the association between cow’s milk consumption and the risk of estrogen receptor-α-positive (ER+) BCa. Milk is a complex biological fluid that increases systemic insulin-like growth factor 1 (IGF-1), insulin and estrogen signaling, and interacting hormonal promoters of BCa. Further potential oncogenic components of commercial milk include exosomal microRNAs (miR-148a-3p, miR-21-5p), bovine meat and milk factors, aflatoxin M1, bisphenol A, pesticides, and micro- and nanoplastics. Individuals with BRCA1 loss-of-function mutations and FTO and IGF1 gain-of-function polymorphisms enhancing IGF-1/mTORC1 signaling may be at increased risk for milk-induced ER+ BCa. Summary Recent prospective epidemiological and pathobiochemical studies identify commercial milk consumption as a critical risk factor of ER+ BCa. Large meta-analyses gathering individuals of different ethnic origins with milk derived from dairy cows of varying genetic backgrounds and diverse feeding procedures as well as missing data on thermal processing of milk (pasteurization versus ultra-heat treatment) make multi-national meta-analyses unsuitable for BCa risk estimations in susceptible populations. Future studies are required that consider all vulnerable periods of breast carcinogenesis to cow’s milk exposure, beginning during the perinatal period and puberty, since these are the most critical periods of mammary gland morphogenesis. Notwithstanding the need for better studies including detailed information on milk processing and vulnerable periods of human breast carcinogenesis, the available evidence suggests that dietary guidelines on milk consumption may have to be reconsidered.

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Consumption of dairy products and odds of breast cancer: an Iranian case–control study

Cited by 2 publications

References 34 publications

Dietary linoleic acid intake in relation to breast cancer: A case-control study

Dietary linoleic acid intake in relation to breast cancer: A case-control study

The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression

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