Consumption of blueberry polyphenols reduces exercise-induced oxidative stress compared to vitamin C

McAnulty, Steven R.; McAnulty, Lisa S.; Nieman, David C.; Dumke, Charles L.; Morrow, Jason D.; Utter, Alan C.; Henson, Dru A.; Proulx, William R.; George, Gretchen

doi:10.1016/j.nutres.2003.10.003

Cited by 45 publications

(49 citation statements)

References 32 publications

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“…Additionally, ROOH originate primarily from oxidation of omega-3 and omega-6 fatty acids found in lipoproteins. These compounds have been found to increase as a result of exercise [34,38]. ROOH were significantly increased in E versus P similar to the F 2 -isoprostanes and were not diminished by the increased plasma antioxidant potential.…”

Section: Discussionmentioning

confidence: 98%

“…F 2 -isoprostanes are recognized as a sensitive and stable marker of oxidative stress and are biologically active as well [22]. We have demonstrated that exercise causes significant increases in these compounds [15,16,34,35]. The acute and chronic physiological and biochemical effects of increased F 2 -isoprostanes after exercise are not currently known.…”

Section: Discussionmentioning

confidence: 99%

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Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise

McAnulty

Nieman

et al. 2005

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise

McAnulty

Nieman

et al. 2005

The Journal of Nutritional Biochemistry

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“…In summary, all of the studies were RCTs, 3 used a crossover design (38,39,47) and 11 used a parallel design (30,(35)(36)(37)(40)(41)(42)(43)(44)(45)(46). The studies were conducted in a range of countries, including 9 in the United States (36, 38-43, 45, 46), 3 in Germany (37,44,47), 1 in the United Kingdom (35), and 1 in Brazil (30).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The studies were conducted in a range of countries, including 9 in the United States (36, 38-43, 45, 46), 3 in Germany (37,44,47), 1 in the United Kingdom (35), and 1 in Brazil (30). A total of 4 studies used individual flavonoid supplements, either anthocyanidins (35) or quercetin (36,42,43), whereas the remaining used a combination of flavonoids (30,(37)(38)(39)(40)(41)(44)(45)(46)(47). In 5 trials, the specific flavonoid and/or amount were not reported (30,37,40,44,45).…”

Section: Study Characteristicsmentioning

confidence: 99%

Effect of Flavonoids on Upper Respiratory Tract Infections and Immune Function: A Systematic Review and Meta-Analysis

Somerville

Braakhuis

Hopkins

2016

Advances in Nutrition

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Previous research on animals indicates flavonoid compounds have immunomodulatory properties; however, human research remains inconclusive. The aim of this systematic review was to assess the efficacy of dietary flavonoids on upper respiratory tract infections (URTIs) and immune function in healthy adults. A created search strategy was run against Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and EMBASE classic, CINAHL, and AMED. The returned studies were initially screened, and 2 reviewers independently assessed the remaining studies for eligibility against prespecified criteria. Fourteen studies, of 387 initially identified, were included in this review, and the primary outcome measure was the effect of flavonoids on URTI incidence, duration, and severity. Of the included studies, flavonoid supplementation ranged from 0.2 to 1.2 g/d. Overall, flavonoid supplementation decreased URTI incidence by 33% (95% CI: 31%, 36%) compared with control, with no apparent adverse effects. Sick-day count was decreased by 40% with flavonoid supplementation, although unclear. Differences in bio-immune markers (e.g., interleukin-6, tumor necrosis factor-α, interferon-γ, neutrophils) were trivial between the intervention and control groups during the intervention and after exercise when a postintervention exercise bout was included. These findings suggest that flavonoids are a viable supplement to decrease URTI incidence in an otherwise healthy population.

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“…Thus, the intake of a diet enriched in antioxidants at moderate level is still the most cautious recommendation to minimize the deleterious actions of free radicals resulting from exercise (Urso and Clarkson 2003). According to this hypothesis, several studies have reported that supplementation with dietary polyphenols diminishes the exercise-induced oxidative stress and decreased inflammatory markers (McAnulty et al 2004;Morillas-Ruiz et al 2005Nieman et al 2007;Panza et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of lemon verbena supplementation on muscular damage markers, proinflammatory cytokines release and neutrophils’ oxidative stress in chronic exercise

et al. 2010

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Intense exercise is directly related to muscular damage and oxidative stress due to excessive reactive oxygen species (ROS) in both, plasma and white blood cells. Nevertheless, exercise-derived ROS are essential to regulate cellular adaptation to exercise. Studies on antioxidant supplements have provided controversial results. The purpose of this study was to determine the effect of moderate antioxidant supplementation (lemon verbena extract) in healthy male volunteers that followed a 90-min running eccentric exercise protocol for 21 days. Antioxidant enzymes activities and oxidative stress markers were measured in neutrophils. Besides, inflammatory cytokines and muscular damage were determined in whole blood and serum samples, respectively. Intense running exercise for 21 days induced antioxidant response in neutrophils of trained male through the increase of the antioxidant enzymes catalase, glutathione peroxidase and glutathione reductase. Supplementation with moderate levels of an antioxidant lemon verbena extract did not block this cellular adaptive response and also reduced exercise-induced oxidative damage of proteins and lipids in neutrophils and decreased myeloperoxidase activity. Moreover, lemon verbena supplementation maintained or decreased the level of serum transaminases activity indicating a protection of muscular tissue. Exercise induced a decrease of interleukin-6 and interleukin-1β levels after 21 days measured in basal conditions, which was not inhibited by antioxidant supplementation. Therefore, moderate antioxidant supplementation with lemon verbena extract protects neutrophils against oxidative damage, decreases the signs of muscular damage in chronic running exercise without blocking the cellular adaptation to exercise.

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Consumption of blueberry polyphenols reduces exercise-induced oxidative stress compared to vitamin C

Cited by 45 publications

References 32 publications

Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise

Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise

Effect of Flavonoids on Upper Respiratory Tract Infections and Immune Function: A Systematic Review and Meta-Analysis

Effect of lemon verbena supplementation on muscular damage markers, proinflammatory cytokines release and neutrophils’ oxidative stress in chronic exercise

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