Consumption of bee bread influences glycaemia and development of diabetes in obese spontaneous diabetic rats

Capcarová, Marcela; Kalafová, Anna; Schwarzová, Marianna; Schneidgenová, Monika; Prnová, Marta Šoltésová; Švík, Karol; Slovák, Lukáš; Kisska, Peter; Kováčik, Anton; Brindza, Ján

doi:10.2478/s11756-019-00337-5

Cited by 15 publications

(15 citation statements)

References 32 publications

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“…In the study by Capcarova et al [19], treatment with BB (700 mg/kg BW for 10 weeks) non-significantly increased BI levels in ZDF rats in contrast to the diabetic control group, which is in line with our findings. Since many flavonoids (including quercetin) found in BB scavenge reactive oxygen species (ROS) and might protect β cells from oxidative damage, they could also increase the circulating BI level.…”

Section: Discussionsupporting

confidence: 93%

“…Although no significant differences in total BW were determined in B1 and B2 groups versus the C one, there is a tendency for higher BW in both treated groups. Capcarova et al [ 19 ] also noted a negligible increase in post-treatment BW of ZDF rats receiving the same dose of BB (700 mg/kg BW for 10 weeks). In the study by Zaid et al [ 33 ], no significant differences in total BW of ovariectomised (OVX) rats following Tualang honey administration were also reported.…”

Section: Discussionmentioning

confidence: 99%

“…Capcarova et al [ 19 ] state that ZDF rats receiving BB at a dose of 700 mg/kg BW (for 10 weeks) had significantly lower BG levels only in the pre-diabetic state versus the diabetic control group. At the end of the treatment, BG did not change significantly between treated and control groups, thus identical to our findings.…”

Section: Discussionmentioning

confidence: 99%

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Bee Bread Can Alleviate Lipid Abnormalities and Impaired Bone Morphology in Obese Zucker Diabetic Rats

et al. 2021

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This study examined for the first time whether bee bread (BB, consisting of monofloral rape bee pollen) could alleviate lipid derangements and reduced bone quality in Zucker diabetic fatty (ZDF) rats, which are considered an appropriate animal model for type 2 diabetes mellitus (T2DM) investigation. Adult ZDF rats were segregated into four groups: lean non-diabetic rats (L group), obese diabetic rats untreated (C group), and those treated with the BB at two doses (500 and 700 mg/kg body weight, respectively, B1 and B2 groups) for 10 weeks. Significantly reduced levels of total cholesterol and triglyceride were recorded in the B2 group versus the C group. In both BB-treated groups, significantly increased relative volume of trabecular bone and trabecular thickness, enhanced density of secondary osteons, accelerated periosteal bone apposition, and improved blood flow were observed. A positive effect of higher dose of BB on femoral weight and cortical bone thickness was also demonstrated. Our results suggest a promising potential of BB to ameliorate T2DM-related complications associated with lipid and bone damages.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Bee Bread Can Alleviate Lipid Abnormalities and Impaired Bone Morphology in Obese Zucker Diabetic Rats

et al. 2021

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“…In this study, the in vitro inhibition effect of α-amylase enzyme associated with Diabetes mellitus was investigated. In literature the effects of bee pollen and perga on Diabetes mellitus are expressed in in vivo studies [2,24]. It is reported that the effect of pollen on the inhibition of two enzymes important for Diabetes mellitus [25].…”

Section: Resultsmentioning

confidence: 99%

“…The collected bee pollen is mixed with honey and bee saliva inside the honeycombs to produce bee bread [2]. Lactic acid fermentation is realized with the help of lactic acid bacteria, and bee pollen is transformed into bee bread.…”

Section: Introductionmentioning

confidence: 99%

α-Amylase Inhibition Properties of Bee Pollen and Bee Bread (Perga)

Keskin

Özkök

2020

Hacettepe Journal of Biology and Chemistry

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A rı poleni ve perga önemli arı ürünleridir. Arı poleni içerdiği protein, yağ, amino asit, vitamin ve fenolik içeriğine göre sahip olduğu besin ve biyoaktif değerleriyle değerli bir arı ürünüdür. Arı poleni arı ekmeğine dönüştürüldüğünde insan sindirim sisteminde daha kolay sindirilebilir hale gelir bunun sebebi fermentasyonun etkisiyle polenin eksin tabakasında kısmen bir parçalanma olmasıdır. Bu nedenle arı ekmeği arı polenine göre daha zengin besin içeriğine sahiptir. Diyabet uzun süreli etkileri olan metabolik ve dejeneratif bir hastalıktır ve α-amilazın inhibisyonu bu hastalığın tedavisi için önem arz etmektedir. Bu çalışmada polen ve perga örneklerinin methanol ekstraktları hazırlandı. Ekstraktların toplam fenolik madde miktarı, antioksidan kapasitesi ve α-amilaz inhibisyon aktiviteleri belirlendi. Polen ve perga örneklerinin toplam fenolik madde miktarı ile antioksidan kapasite miktarları ise sırasıyla 5.57-6.93 mg GAE/g ve 74.56-97.66 µmol FeSO 4 .7H 2 O/g sample olarak belirlendi. Polen ve perga ekstraktlarının α-amilaz inhibisyonu için IC 50 değerleri sırasıyla 4.21 ve 3.57 mg/mL olarak bulundu. Sonuç olarak Perganın Diabetes mellitus üzerinde daha etikili olabileceği ifade edilebilir.

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Natural Remedies and Health; A Review of Bee Pollen and Bee Bread Impact on Combating Diabetes and Obesity

El-Seedi,

El-Wahed,

Salama

et al. 2024

Curr Nutr Rep

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Consumption of bee bread influences glycaemia and development of diabetes in obese spontaneous diabetic rats

Cited by 15 publications

References 32 publications

Bee Bread Can Alleviate Lipid Abnormalities and Impaired Bone Morphology in Obese Zucker Diabetic Rats

Bee Bread Can Alleviate Lipid Abnormalities and Impaired Bone Morphology in Obese Zucker Diabetic Rats

α-Amylase Inhibition Properties of Bee Pollen and Bee Bread (Perga)

Natural Remedies and Health; A Review of Bee Pollen and Bee Bread Impact on Combating Diabetes and Obesity

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