Consumption of ADD-X and Repeatedly Heated Palm Oil on the Blood Pressure and Oxidative Stress Markers in Ovarectmized Rats

Sukalingam, Kumeshini; Jaarin, Kamsiah; Saad, Qodriyah Haji Mohd; Mohamed, Suhaila; Othman, Faridah

doi:10.3923/ijp.2016.514.522

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…In this study, it was proven that repeated heating of frying oils elevated the degree of lipid peroxidation in the oils. Both heated oil groups had almost or evidently exceeded the upper limit of peroxide value (10 mEq/kg) in foods set by AOCS [15], which was similarly reported by other studies [7,13,22]. Repeated heating diminishes the antioxidant content in the oils [3].…”

Section: Discussionsupporting

confidence: 79%

Addition of Citrus Leaf Extract into Frying Oil Prevents Hypertension and Improves Vascular Reactivity in Heated Oil-Fed Rats

Suhaimi¹,

Zuhair²,

Azlan³

et al. 2020

JFNR

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The use of repeatedly heated frying oil is hazardous to health, due to oxidative process that occurs in the oil. Addition of an additive with antioxidant property could lessen the detrimental effects of repeated frying in the oils. Citrus leaf extract (CLE) supplementation was reported to possess antioxidant and blood pressure-lowering properties. Our study aimed to determine the effects of CLE addition into frying oil in rats fed with repeatedly heated oil diet. Seven groups of male Sprague-Dawley rats were given fresh and heated oil diets (five-time-and tentime-heated palm oil), with and without the CLE addition for 16 weeks. CLE addition decreased peroxide value and augmented the total phenolics content in the heated oils. CLE addition reversed the negative effects of heated oil on nitric oxide level, systolic blood pressure, and vascular reactivity. In conclusion, these findings show that CLE has the ability to reduce oxidative damage caused by thermal degradation in frying oil and subsequently lowers the risk of hypertension in rats that consumed heated oil.

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Section: Discussionsupporting

confidence: 79%

Addition of Citrus Leaf Extract into Frying Oil Prevents Hypertension and Improves Vascular Reactivity in Heated Oil-Fed Rats

Suhaimi¹,

Zuhair²,

Azlan³

et al. 2020

JFNR

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“…Previous studies have shown that chronic ingestion of repeatedly-heated vegetable oil is associated with reduction in the plasma NO level (Leong 2009; D r a f t chromatography-mass spectrometry (LC-MS) elucidation (Siti et al 2017). An earlier study showed that CLE added to frying oil reduced blood pressure and oxidative stress in an atherosclerotic rat model (Sukalingam et al 2016). A dietary supplementation of CLE also reduced the rise in blood pressure and vascular remodelling in repeatedly heated vegetable oil-induced hypertensive rats (Siti et al 2017).…”

Section: Introductionmentioning

confidence: 96%

Effects of citrus leaf extract on aortic vascular reactivity in hypertensive rats fed repeatedly heated vegetable oil

Siti

Kamisah

Mohamed

et al. 2019

Appl. Physiol. Nutr. Metab.

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The prolonged intake of diet containing repeatedly heated vegetable oil can cause hypertension in the long run. In this study, the effects of citrus leaf extract (CLE) supplementation on vascular reactivity, plasma nitrite, and aortic structure in repeatedly-heated vegetable oil-induced hypertension rats were investigated. Male Sprague-Dawley rats (n = 56) were divided into seven groups corresponding to the respective diets. For 16 weeks, one group was given standard rat chow (control) while other groups were given diets containing 15% w/w of palm oil, fresh palm oil (FPO), five-time-heated palm oil (5HPO) and ten-time-heated palm oil (10HPO), with or without 0.15% w/w CLE incorporation (FPO+CLE, 5HPO+CLE or 10HPO+CLE). Plasma nitrite levels were measured before and at 16 weeks of treatment. After 16 weeks, the rats were sacrificed and aortae were harvested for measuring vascular reactivity and for microscopic study. CLE supplementation had significantly reduced the loss of plasma nitrite and attenuated the vasoconstriction response to phenylephrine in the 5HPO group but not in the 10HPO group. However, CLE had no significant effect on the vasorelaxation response to acetylcholine and sodium nitroprusside. The elastic lamellae of tunica media in 5HPO, 10HPO, and 10HPO+CLE groups appeared disorganised and disrupted. Obtained findings suggested that CLE was able to enhance nitric oxide bioavailability that might dampen the vasoconstriction effect of phenylephrine.

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“…Heating causes chemical changes like thermal oxidation and polymerization in the oil, leading to a configuration change in the fatty acids from cis to trans [61]. Addition of C. hystrix leaf extract at 1% into frying oils that were heated five and ten times reduced peroxide levels and increased the total phenolic content of the oils [63,64] (Table 4). Reduction in the oxidized content of the oil by the addition of the extract prevented the elevation of blood pressure in rats that were fed the heated oils for 16 weeks, starting on week 4.…”

Section: Effects On Hypertensionmentioning

confidence: 99%

“…Consumption of such oils prevented the development of hypertension due to preservation of vascular microstructure. Another study [64] investigated a similar treatment of frying oils with C. hystrix extract and enrichment with 2% cholesterol. The diet was then fed to ovariectomized female rats for six months.…”

Section: Effects On Hypertensionmentioning

confidence: 99%

Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders

2022

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Metabolic disorders like diabetes mellitus, hypertension, dyslipidemia, and obesity are major medical problems globally. The incidence of these disorders has increased tremendously in recent years. Studies have demonstrated that plants with antioxidant and anti-inflammatory properties have beneficial effects on these disorders. One of these plants is Citrus hystrix DC, commonly known as kaffir lime. This review aims to present updates on the progress of research regarding the use of C. hystrix in metabolic disorders. Phytochemical compounds, including β-pinene, sabinene, citronellal, and citronellol, have been detected in the plant; and its extract exhibited potential antidiabetic, antihyperlipidemic and anti-obesity activity, as well as prevention of development of hypertension. These beneficial properties may be attributable to the presence of bioactive compounds which have therapeutic potential in treating these metabolic disorders. The compounds have the potential to be developed as candidate drugs. This review will assist in validating the regulatory role of the extract and its bioactive compounds on metabolic disorders, thus expediting future research in the area.

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Consumption of ADD-X and Repeatedly Heated Palm Oil on the Blood Pressure and Oxidative Stress Markers in Ovarectmized Rats

Cited by 10 publications

References 24 publications

Addition of Citrus Leaf Extract into Frying Oil Prevents Hypertension and Improves Vascular Reactivity in Heated Oil-Fed Rats

Addition of Citrus Leaf Extract into Frying Oil Prevents Hypertension and Improves Vascular Reactivity in Heated Oil-Fed Rats

Effects of citrus leaf extract on aortic vascular reactivity in hypertensive rats fed repeatedly heated vegetable oil

Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders

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