Consumption of a meal containing refined barley flour bread is associated with a lower postprandial blood glucose concentration after a second meal compared with one containing refined wheat flour bread in healthy Japanese: A randomized control trial

Matsuoka, Tsubasa; Tsuchida, Asuka; Yamaji, Ayako; Kurosawa, Chihiro; Shinohara, Manabu; Takayama, Ichiro; Nakagomi, Hiromi; Izumi, Keiko; Ichikawa, Yoko; Hariya, Natsuyo; Yamashita, Sayaka; Mochizuki, Kazuki

doi:10.1016/j.nut.2019.110637

Cited by 22 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Barley contains the abundant soluble dietary fiber β-glucan, which reduces postprandial blood glucose concentration. In a randomized, double-blind, placebo-controlled, crossover study conducted in healthy individuals, the circulating glucose concentrations of individuals that consumed barley flour bread containing 2.5 g of β-glucan were lower than those of individuals that consumed wheat flour bread 30 min after the meal [ 13 ]. It has also been reported that the supplementation of a high-fat diet with 10% germinated barley for 14 weeks reduces liver fibrosis in rats with steatohepatitis but no T2DM [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Consumption of barley ameliorates the diabetic steatohepatitis and reduces the high transforming growth factor β expression in mice grown in α-minimum essential medium in vitro as embryos

Ishiyama

Kimura

Umihira

et al. 2021

Biochemistry and Biophysics Reports

Self Cite

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD), which includes the subtype non-alcoholic steatohepatitis (NASH), is a major complication of type 2 diabetic mellitus (T2DM), even among non-obese patients. However, the exact cause of NAFLD/NASH in non-obese patients with T2DM is unclear. We studied a non-obese mouse model of T2DM created through the malnourishment of embryos by culture in vitro for 48 h in α-minimum essential medium (MEM) at the two-cell stage. We compared the development of steatohepatitis in these MEM mice with control mice that were similarly cultured in standard potassium simplex-optimized medium (KSOM). We also studied the effects of 10 weeks of consumption of barley, which contains large amounts of the soluble fiber β-glucan, on the steatohepatitis of the adult MEM mice. The size of lipid droplets, the area of fibrosis, and the mRNA expression of the transforming growth factor beta ( Tgfb ) gene in the liver were higher in adult MEM mice fed a rice-based diet than in KSOM mice fed the same diet. However, barley consumption reduced the area of fibrosis and TGFB expression in MEM mice. In conclusion, adult mice that are cultured in MEM at the two-cell embryo stage develop steatohepatitis and T2DM, accompanied by higher hepatic TGFB expression, than KSOM controls. Furthermore, the consumption of barley during adulthood ameliorates the steatohepatitis and reduces the TGFB expression.

show abstract

Section: Introductionmentioning

confidence: 99%

Consumption of barley ameliorates the diabetic steatohepatitis and reduces the high transforming growth factor β expression in mice grown in α-minimum essential medium in vitro as embryos

Ishiyama

Kimura

Umihira

et al. 2021

Biochemistry and Biophysics Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, HGB imparts a second meal effect, which is induced through intestinal fermentation [15]. In a human intervention study, it was reported that the postprandial blood glucose rise was suppressed when a standard diet without barley was consumed at lunch after the intake of a HGB diet at breakfast [35,36].…”

Section: Discussionmentioning

confidence: 99%

High β-Glucan Barley Supplementation Improves Glucose Tolerance by Increasing GLP-1 Secretion in Diet-Induced Obesity Mice

Suzuki

Aoe

2021

Nutrients

View full text Add to dashboard Cite

The aim of this study was to investigate the underlying mechanism for the improvement of glucose tolerance following intake of high β-glucan barley (HGB) in terms of intestinal metabolism. C57BL/6J male mice were fed a fatty diet supplemented with HGB corresponding to 5% of dietary fiber for 83 days. An oral glucose tolerance test was performed at the end of the experimental period. The concentration of short-chain fatty acids (SCFAs) in the cecum was analyzed by GC–MS (gas chromatography–mass spectrometry). The mRNA expression levels related to L cell function in the ileum were measured by real-time PCR. Glucagon-like peptide-1 (GLP-1) levels in the portal vein and cecal content were assessed by enzyme-linked immunosorbent assay. GLP-1-producing L cells of the ileum were quantified by immunohistochemistry. HGB intake improved glucose tolerance and increased the cecal levels of SCFAs, acetate, and propionate. The number of GLP-1-positive L cells in the HGB group was significantly higher than in the control group. GLP-1 levels in the portal vein and cecal GLP-1 pool size in the HGB group were significantly higher than the control group. In conclusion, we report improved glucose tolerance after HGB intake induced by an increase in L cell number and subsequent rise in GLP-1 secretion.

show abstract

“…Barley improves metabolic dysfunction, increases the diversity of the gut microbiota, and increases bacteria such as Blautia (4) . Additionally, barley lowers postprandial blood glucose in healthy (3) and diabetic patients (5) , and lowers cholesterol concentrations in Japanese people with mild metabolic syndrome after 12 weeks of consumption (6) . Therefore, barley consumption has many potential benefits to global health.…”

Section: Introductionmentioning

confidence: 99%

“…Barley is an important cereal that contains the soluble fibre β-glucan (3) . Barley improves metabolic dysfunction, increases the diversity of the gut microbiota, and increases bacteria such as Blautia (4) .…”

Section: Introductionmentioning

confidence: 99%

“…2 Mann-Whitney U-test (crude P value)3 Mann-Whitney U-test adjusted with FDR (False Discovery Rate) method Multiple regression analyses adjusted with dietary factors Supplemental Table5shows that Butyricicoccus and Ruminococcus 2 were associated with barley consumption after adjustment with dietary fibre, cereal, or legumes, but not with natto. Conversely, All rights reserved.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study

Matsuoka

Hosomi

Park

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Objective: Barley contains abundant soluble β –glucan fibres, which have established health benefits. In addition, the health benefits conferred by the gut microbiota have attracted considerable interest. However, few studies have focused on the barley intake and microbiota of the Japanese population. In this study, we aimed to identify the relationship between the barley consumption and gut microbiota composition of the Japanese population. Research Methods & Procedures: A total of 236 participants were recruited in Japan, and 94 participants with no complication of diabetes, hypertension, and dyslipidemia were selected for the study. We analysed faecal samples from the participants, their medical check –up results, and responses to questionnaires about dietary habits. The participants were grouped according to their median barley intake. Then, we assessed the relative abundance of 50 microbial genera throughout the group and selected 20 that differed at P < 0.1 (Mann–Whitney U –test). We also analysed the networks and clustering of the 20 selected genera. Results: According to their relative abundance, Bifidobacterium, Anaerostipes, and Butyricicoccus were candidate characteristic microbiota of the group that consumed large amounts of barley (P < 0.05). Furthermore, network and cluster analyses revealed that barley directly correlated with Bifidobacterium and Butyricicoccus. Conclusions: Barley consumption generates changes in the intestinal microbiota of the Japanese population. We found that Bifidobacterium, Anaerostipes, and Butyricicoccus abundance was positively associated with barley consumption. This study showed that barley is important for gut microbiota and relates to Japanese traditional food like natto.

show abstract

Consumption of a meal containing refined barley flour bread is associated with a lower postprandial blood glucose concentration after a second meal compared with one containing refined wheat flour bread in healthy Japanese: A randomized control trial

Cited by 22 publications

References 15 publications

Consumption of barley ameliorates the diabetic steatohepatitis and reduces the high transforming growth factor β expression in mice grown in α-minimum essential medium in vitro as embryos

Consumption of barley ameliorates the diabetic steatohepatitis and reduces the high transforming growth factor β expression in mice grown in α-minimum essential medium in vitro as embryos

High β-Glucan Barley Supplementation Improves Glucose Tolerance by Increasing GLP-1 Secretion in Diet-Induced Obesity Mice

Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study

Contact Info

Product

Resources

About