Consumption of a green tea extract–curcumin drink decreases blood urea nitrogen and redox iron in β-thalassemia patients

Koonyosying, Pimpisid; Tantiworawit, Adisak; Hantrakool, Sasinee; Utama‐ang, Niramon; Cresswell, Michael W.; Fucharoen, Suthat; Porter, John B.; Srichairatanakool, Somdet

doi:10.1039/c9fo02424g

Cited by 26 publications

(18 citation statements)

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“…With this in mind, commercial citric acid, which is a weak tridentate iron (Fe 2+ and Fe 3+ )-chelating chelator [ 28 , 29 ], was added as a food-flavoring and iron-stabilizing agent to the drinks. For the satisfaction of consumers, 0.1% citric acid chelator (food grade) was added as an ingredient to soya sauces that had been fortified with ferrous sulfate, sodium FeEDTA, ferric ammonium citrate, ferrous lactate and ferrous gluconate [ 30 ], which was consistent with our recent study [ 31 ]. Hepcidin is an important iron-regulatory hormone, for which the suppression under anemic condition allows for more dietary iron to be absorbed during upregulation by oral administration of high-dose iron.…”

Section: Discussionsupporting

confidence: 54%

Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects

et al. 2021

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Iron fortifications are used for the treatment of iron-deficiency anemia; however, iron dosing may cause oxidative damage to the gut lumen. Thai Sinlek rice is abundant in iron and contains phytochemicals. We aimed at evaluating the effect of an iron-rice (IR) hydrolysate drink (100 mL/serving) on neurological function, red cell indices and iron status in elders. Healthy elderly subjects were divided into three non-anemic groups and one anemic group. The non-anemic groups consumed one WR (2 mg iron/serving) and two IR drinks (15 and 27 mg iron/serving) (groups A, B and D, respectively), while the anemic group consumed one IR drink (15 mg iron serving) (group C) every day for 30 days. There were no significant differences in the MMSE Thai 2002 and PHQ9 test scores for members of all groups, while the nutrition scores and body weight values of group D subjects were significantly increased. Hemoglobin (Hb) and mean corpuscular hemoglobin concentrations increased significantly only in group C. Serum iron and transferrin saturation levels tended to increase in group A, while these levels were decreased in members of group C. Serum antioxidant activity levels were increased in all groups, and were highest in group C. Thus, consumption of an IR drink for 15 days functioned to increase Hb and antioxidant capacity levels in anemic elders.

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Section: Discussionsupporting

confidence: 54%

Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects

et al. 2021

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“…Taken together, green tea polyphenols and curcuminoids present in the drink could possibly interfere absorption of dietary iron and mobilize delivery of iron to the erythrons [65,79,119]. Taken all our studies, we summarize the applications of nutraceutical green tea extract for the amelioration of iron-overloaded cells, β-thalassemic mice, and patients with β-thalassemia (Figure 5) [79,84,106,116,[119][120][121][122][123][124][125][126][127][128]. In our expectations, we hope the patients will have safer chelation therapy, a better quality of lives, and good health.…”

Section: Patients With β-Thalassemiamentioning

confidence: 74%

Nutraceutical Benefits of Green Tea in Beta-Thalassemia with Iron Overload

Koonyosying¹,

Fucharoen²,

Srichairatanakool³

2020

Beta Thalassemia

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Secondary iron overload in patients with β-thalassemia is caused by multiple blood transfusions and increased iron absorption. Most of them die from cardiac arrest and infections while others from oxidative tissue damage and organ dysfunction. Under high saturation of transferrin with iron, redox-active iron such as nontransferrin-bound iron, labile plasma iron, and cellular labile iron pool is prone to the production of reactive oxygen species, oxidized biomolecules, oxidative tissue damages, and complications. Iron chelation therapy and antioxidant supplementation are a supportive treatment for patients' better quality of life and life expectancy. Green tea (Camellia sinensis) extract (GTE) is abundant with polyphenols, mainly epigallocatechin-3-gallate and nutraceuticals, which are beneficial for cell functions and health. Importantly, GTE possesses antioxidant, free radical scavenging, metal-chelating, anti-hemolysis properties in cell cultures, animals, and humans. This article has reported modes of actions and challenged such wonderful properties of green tea used to remove excessive iron, scavenge harmful radicals, restore malfunctions of vital organs, and treat patients with β-thalassemia with iron overload. Infeasibility and sustainability, the benefits of green tea can be applied for use in other diseases with iron toxicity and oxidative stress.

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“…In month 1 and 2 of the treatments, there were a decrease of serum MDA (−0.07 ± 2.95 and −0.87 ± 1.68 μM, respectively), NTBI (−1.20 ± 8.03 and −3.93 ± 3.83 μM, respectively), and LPI (1.91 ± 4.99 and −1.10 ± 2.94 μM, respectively) and increase of serum antioxidant activity (5.08 ± 8.86 and 0.28 ± 13.39 mg trolox equivalent/ml, respectively). These findings suggest GT-CUR drink would increase erythropoiesis, improve liver and kidney function, and diminish oxidative stress and iron overload in thalassemia patients [125]. Surprisingly, we demonstrate that treatment of GTE (1-10 μM EGCG equivalent) decreased cellular iron approximately 45% and ROS level in a concentration-dependent manner in ironloaded pancreatic cell line (RINm5F) when compared with control cells.…”

Section: Green Teamentioning

confidence: 55%

Diet-Related Thalassemia Associated with Iron Overload

Srichairatanakool¹,

Koonyosying²,

Fucharoen³

2020

Personalized Medicine, in Relation to Redox State, Diet and Lifestyle

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Thalassemia is an inherited disease caused by the genetic disorder of α-and β-globin genes, resulting in ineffective erythropoiesis and chronic anemia. Transfusion-dependent β-thalassemia patients require red cell transfusion to maintain their blood hemoglobin level in the normal range, whereas non-transfusion-dependent thalassemia patients increase duodenal absorption of dietary iron in an attempt to accelerate erythropoiesis. These changes give rise to iron overload, oxidative stress, organ dysfunction, and other complications. Effective iron chelators are necessary to achieve negative iron balance and to relieve such complications associated with iron overload. Some pharmaceuticals such as hydroxyurea, N-acetylcysteine, ascorbic acid, vitamin E, and glutathione are also given to thalassemia patients in order to overcome oxidative cell and tissue damage and to generate a better quality of life. Interestingly, functional natural products (such as mango, tea, caffeine, and curcumin), vegetables, and cereal (e.g., rice) are helpful for their health-providing properties by supplementing the endogenous antioxidant defensive power in the body. Natural products exhibit many pharmacological activities, but they are safer if used in the traditional manner.

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Consumption of a green tea extract–curcumin drink decreases blood urea nitrogen and redox iron in β-thalassemia patients

Abstract: The most important cause of death in β-thalassemia major patients is organ dysfunction due to iron deposits.

Cited by 26 publications

References 58 publications

Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects

Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects

Nutraceutical Benefits of Green Tea in Beta-Thalassemia with Iron Overload

Diet-Related Thalassemia Associated with Iron Overload

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